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Tollip Gene Detail
Summary
  • Symbol
    Tollip
  • Name
    toll interacting protein
  • Synonyms
    4930403G24Rik, 4931428G15Rik, Toll interacting protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891808
    NCBI Gene: 54473
  • Gene Overview
    MyGene.info: TOLLIP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:141874813-141918507 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43695 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 87.34 cM, cytoband F5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TOLLIP, toll interacting protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TOLLIP, toll interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IL-1RAcPIP
  • Links
    NCBI Gene ID: 54472
    neXtProt AC: NX_Q9H0E2
    UniProt: Q9H0E2

  • Chr Location
    11p15.5; chr11:1274368-1309666 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display normal immune cell composition but reduced cytokine production when stimulated with low concentrations of some inducers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000023241 VEGA Gene Model | MGI Sequence Detail 43695 C57BL/6J ±  kb
    transcript OTTMUST00000056276 VEGA | MGI Sequence Detail 3788 Not Applicable  
    polypeptide OTTMUSP00000027021 VEGA | MGI Sequence Detail 274 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      208 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1921868, MGI:1922969
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:64825 Volpe F, et al., The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex. FEBS Lett. 1997 Dec 8;419(1):41-4
    • Latest
      J:251264 Kumazoe M, et al., Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression. J Immunol. 2017 Nov 1;199(9):3261-3269

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory