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Ppp4c
Gene Detail
 Symbol
Name
ID
Ppp4c
protein phosphatase 4, catalytic subunit
MGI:1891763
Synonyms 1110002D08Rik, PPX
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:126785907-126792471 bp, - strand
From Ensembl annotation of GRCm38

  6565 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:2038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp4c

Human
homologs
Human Homolog PPP4C, protein phosphatase 4, catalytic subunit
NCBI Gene ID 5531
neXtProt AC  NX_P60510
Human Synonyms  PP4, PP4C, PPH3, PPP4, PPX
Human Chr (Location)  16p11.2; chr16:30075976-30085377 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(27) Targeted(7)
Genomic Mutations involving Ppp4c (2)
Incidental mutations (data from Mutagenetix , APF )
 
Embryonic Ppp4c-deficiency leads to early embryonic lethality.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Ppp4c interacts with 77 markers (Mir7-1, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process dephosphorylation, NIK/NF-kappaB signaling, ...
Component cytoplasm, cytoskeleton, ...
Function hydrolase activity, lamin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (58)    Tissues (14)    Images (31)
Theiler Stages: 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 58
cDNA source data(115)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(116) cDNA(116)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030697 (Evidence)
Entrez Gene56420 (Evidence)
UniGene41998
DFCITC1576246, TC1607031, TC1634180
DoTSDT.40181512, DT.535381, DT.91329198
EC3.1.3.16
Consensus CDS ProjectCCDS21844.1
International Mouse Knockout Project StatusPpp4c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030697 Ensembl Gene Model | MGI Sequence Detail 6565 C57BL/6J ±  kb
transcript ENSMUST00000032936 Ensembl | MGI Sequence Detail 1293 Not Applicable 
polypeptide ENSMUSP00000032936 Ensembl | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology PR:000013152 serine/threonine-protein phosphatase 4 catalytic subunit
References (Earliest) J:64812 Hu MC, et al., Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity. J Biol Chem. 1998 Dec 11;273(50):33561-5
(Latest) J:204399 Su YW, et al., The serine/threonine phosphatase PP4 is required for pro-B cell development through its promotion of immunoglobulin VDJ recombination. PLoS One. 2013;8(7):e68804
All references(43)
Other
accession IDs
MGI:2142119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory