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Ppp4c
Gene Detail
Symbol

Name
ID
Ppp4c
protein phosphatase 4, catalytic subunit
MGI:1891763
Synonyms
1110002D08Rik, PPX
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:126785907-126792471 bp, - strand
From Ensembl annotation of GRCm38

  6565 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PPP4C
Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp4c

Human
homologs
PPP4C, protein phosphatase 4, catalytic subunit
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5531
neXtProt AC: NX_P60510

Human Synonyms: PP4, PP4C, PPH3, PPP4, PPX, PP-X

Human Chr (Location): 16p11.2; chr16:30075976-30085377 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(35) : Gene trapped(27) Targeted(8)
Genomic Mutations involving Ppp4c (4)
Incidental mutations (data from Mutagenetix , APF )
 
Embryonic Ppp4c-deficiency leads to early embryonic lethality.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Ppp4c interacts with 77 markers (Mir7-1, Mir27a, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process dephosphorylation, NIK/NF-kappaB signaling, ...
Component cytoplasm, cytoskeleton, ...
Function hydrolase activity, lamin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (58)    Tissues (14)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 58
cDNA source data(115)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ppp4c ; ZFIN ppp4cb    NEW 
Molecular
reagents
All nucleic(116) cDNA(116)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000030697 (Evidence)
Entrez Gene 56420 (Evidence)
UniGene 41998
DFCI TC1576246, TC1607031, TC1634180
DoTS DT.91329198, DT.535381, DT.40181512
EC 3.1.3.16
Consensus CDS Project CCDS21844.1
International Mouse Phenotyping Consortium Status Ppp4c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030697 Ensembl Gene Model | MGI Sequence Detail 6565 C57BL/6J ±  kb
transcript ENSMUST00000032936 Ensembl | MGI Sequence Detail 1293 Not Applicable 
polypeptide ENSMUSP00000032936 Ensembl | MGI Sequence Detail 307 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(57 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004843 Metallophosphoesterase domain
InterPro IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology PR:000013152 serine/threonine-protein phosphatase 4 catalytic subunit
References
(Earliest) J:64812 Hu MC, et al., Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity. J Biol Chem. 1998 Dec 11;273(50):33561-5
(Latest) J:213141 Lee DH, et al., Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks. Mol Cell. 2014 May 8;54(3):512-25
All references(43)
Other
accession IDs
MGI:2142119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory