Ppp4c
Gene Detail

Symbol Name ID

Ppp4c protein phosphatase 4, catalytic subunit MGI:1891763

Synonyms

1110002D08Rik, PPX

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:126785907-126792471 bp, - strand From Ensembl annotation of GRCm38   6565 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2038  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: serine/threonine-protein phosphatase, conventional type
Gene Tree: Ppp4c

Human homologs

Human Homolog		PPP4C, protein phosphatase 4, catalytic subunit
NCBI Gene ID		5531
neXtProt AC		NX_P60510
Human Synonyms		PP4, PP4C, PPH3, PPP4, PPX
Human Chr (Location)		16p11.2; chr16:30087385-30096695 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(32) : Targeted(5) Gene trapped(27)
 

Embryonic Ppp4c-deficiency leads to early embryonic lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	dephosphorylation, protein phosphorylation, ...
Component	cytoplasm, cytoskeleton, ...
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (58)    Tissues (13)    Images (31)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	58

cDNA source data(5)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(6)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000030697 (Evidence)
Entrez Gene	56420 (Evidence)
DFCI	TC1576246, TC1607031, TC1634180
DoTS	DT.40181512, DT.535381, DT.91329198
EC	3.1.3.16
Consensus CDS Project	CCDS21844.1
International Mouse Knockout Project Status	Ppp4c

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030697	Ensembl Gene Model | MGI Sequence Detail	6565	C57BL/6J
transcript	ENSMUST00000032936	Ensembl | MGI Sequence Detail	1293	Not Applicable
polypeptide	ENSMUSP00000032936	Ensembl | MGI Sequence Detail	307	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

SNPs within 2kb(57 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR004843	Phosphoesterase domain
InterPro	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Protein Ontology	PR:000013152	serine/threonine-protein phosphatase 4 catalytic subunit

References

(Earliest) J:64812 Hu MC, et al., Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity. J Biol Chem. 1998 Dec 11;273(50):33561-5
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(39)

Other accession IDs

MGI:2142119