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Ppp4c Gene Detail
Summary
  • Symbol
    Ppp4c
  • Name
    protein phosphatase 4, catalytic subunit
  • Synonyms
    1110002D08Rik, PPX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891763
    NCBI Gene: 56420
Location & Maps
more
  • Sequence Map
    Chr7:126785907-126792471 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6565 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PPP4C, protein phosphatase 4 catalytic subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PPP4C, protein phosphatase 4 catalytic subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PP4, PP4C, PPH3, PPP4, PPX, PP-X
  • Links
    NCBI Gene ID: 5531
    neXtProt AC: NX_P60510

  • Chr Location
    16p11.2; chr16:30075976-30085377 (+)  GRCh38.p2

Human Diseases
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  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 5 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Gene trapped
    27
  • Targeted
    8
  • Genomic Mutations
    4 involving Ppp4c
  • Incidental Mutations
Embryonic Ppp4c-deficiency leads to early embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030697 Ensembl Gene Model | MGI Sequence Detail 6565 C57BL/6J ±  kb
transcript ENSMUST00000032936 Ensembl | MGI Sequence Detail 1293 Not Applicable  
polypeptide ENSMUSP00000032936 Ensembl | MGI Sequence Detail 307 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013152 serine/threonine-protein phosphatase 4 catalytic subunit
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, apaH type
    IPR029052 Metallo-dependent phosphatase-like
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
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  • All nucleic 116
    cDNA 116

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142119
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Diseases 5
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:64812 Hu MC, et al., Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity. J Biol Chem. 1998 Dec 11;273(50):33561-5
  • Latest
    J:222517 Chen MY, et al., PP4 is essential for germinal center formation and class switch recombination in mice. PLoS One. 2014;9(9):e107505

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory