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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ppp4c
protein phosphatase 4, catalytic subunit
MGI:1891763
27 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ppp4cem1(IMPC)Ics/Ppp4c+
C57BL/6N-Ppp4cem1(IMPC)Ics/Ics 		abnormal contextual conditioning behavior J:211773
increased circulating bilirubin level J:211773
increased heart weight J:211773
Ppp4cem1Qys/Ppp4cem1Qys
Tg(Stra8-icre)1Reb/0
involves: 129S/SvEv * C57BL/6 * FVB/NJ 		abnormal seminiferous tubule morphology J:309155
abnormal sperm midpiece morphology J:309155
abnormal spermatocyte morphology J:309155
arrest of spermiogenesis J:309155
asthenozoospermia J:309155
decreased fertilization frequency J:309155
decreased sperm progressive motility J:309155
decreased testis weight J:309155
impaired binding of sperm to zona pellucida J:309155
impaired fertilization J:309155
increased male germ cell apoptosis J:309155
kinked sperm flagellum J:309155
male infertility J:309155
oligozoospermia J:309155
small testis J:309155
Ppp4ctm1Tht/Ppp4ctm1Tht
Tg(Lck-cre)548Jxm/0
involves: C57BL/6 * CBA 		abnormal positive T cell selection J:117684
abnormal T cell activation J:117684
abnormal T cell differentiation J:117684
decreased CD4-positive, alpha-beta T cell number J:117684
decreased CD8-positive, alpha-beta T cell number J:117684
decreased double-positive T cell number J:117684
decreased single-positive T cell number J:117684
increased double-negative T cell number J:117684
Ppp4ctm2Tht/Ppp4ctm2Tht
Not Specified 		embryonic lethality during organogenesis, complete penetrance J:117684
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory