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Lgr4
Gene Detail
 Symbol
Name
ID
Lgr4
leucine-rich repeat-containing G protein-coupled receptor 4
MGI:1891468
Synonyms A330106J01Rik, A930009A08Rik, Gpr48
Feature Type protein coding gene
Genetic Map
Chromosome 2
56.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:109917647-110014257 bp, + strand
From VEGA annotation of GRCm38

  96611 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10226  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: leucine-rich repeat-containing G protein-coupled receptor 4/5/6
Gene Tree: Lgr4

Human
homologs
Human Homolog LGR4, leucine-rich repeat containing G protein-coupled receptor 4
NCBI Gene ID 55366
neXtProt AC  NX_Q9BXB1
Human Synonyms  BNMD17, GPR48
Human Chr (Location)  11p14-p13; chr11:27365961-27472787 (-)  GRCh38
Alleles
and
phenotypes
All alleles(89) : Targeted(5) Gene trapped(84)
 
Homozygotes for a knock-out allele show embryonic and perinatal death, open eyelids, and abnormal renal development. One gene trap mutation leads to reduced body weight, sterility, and impaired male reproductive tract development. Another gene trap mutation causes ocular anterior segment anomalies.
 
Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process bone mineralization, bone remodeling, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function protein binding, protein-hormone receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (44)    Tissues (35)    Images (2)
Theiler Stages: 10, 18, 20, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 24
In situ reporter (knock in) 8
Northern blot 12
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(13) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000015138 (Evidence)
Ensembl Gene ModelENSMUSG00000050199 (Evidence)
Entrez Gene107515 (Evidence)
DFCITC1583322, TC1606415, TC1627511, TC1691306
DoTSDT.40164921, DT.91378703, DT.91561062
NIA Mouse Gene IndexU002223
Consensus CDS ProjectCCDS38195.1
International Mouse Knockout Project StatusLgr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015138 VEGA Gene Model | MGI Sequence Detail 96611 C57BL/6J ±  kb
transcript OTTMUST00000035907 VEGA | MGI Sequence Detail 5060 Not Applicable 
polypeptide OTTMUSP00000016116 VEGA | MGI Sequence Detail 951 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(579 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002131 Glycoprotein hormone receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000001591 leucine-rich repeat-containing G-protein coupled receptor 4
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:204016 Luo W, et al., Lgr4 is a key regulator of prostate development and prostate stem cell differentiation. Stem Cells. 2013 Nov;31(11):2492-505
All references(71)
Other
accession IDs
MGI:1925178, MGI:2441840

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory