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Gene Detail
leucine-rich repeat-containing G protein-coupled receptor 4
Synonyms A330106J01Rik, A930009A08Rik, Gpr48
Feature Type protein coding gene
Genetic Map
Chromosome 2
56.65 cM
Detailed Genetic Map ± 1 cM

Mapping data(2)
Sequence Map
Chr2:109917647-110014257 bp, + strand
From VEGA annotation of GRCm38

  96611 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:10226  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: leucine-rich repeat-containing G protein-coupled receptor 4/5/6
Gene Tree: Lgr4

Human Homolog LGR4, leucine-rich repeat containing G protein-coupled receptor 4
NCBI Gene ID 55366
neXtProt AC  NX_Q9BXB1
Human Synonyms  BNMD17, GPR48
Human Chr (Location)  11p14-p13; chr11:27365961-27472787 (-)  GRCh38
alleles, and
All mutations/alleles(89) : Gene trapped(84) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for a knock-out allele show embryonic and perinatal death, open eyelids, and abnormal renal development. One gene trap mutation leads to reduced body weight, sterility, and impaired male reproductive tract development. Another gene trap mutation causes ocular anterior segment anomalies.
Phenotype Images(4)
Lgr4 interacts with 313 markers (Mir7-1, Mir7-2, Mir10b, ...)
Gene Ontology
All GO classifications: (39 annotations)
Process bone mineralization, bone remodeling, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function protein binding, protein-hormone receptor activity, ...
External Resources: FuncBase
Literature Summary: (16 records)
Data Summary: Results (44)    Tissues (35)    Images (2)
Theiler Stages: 10, 18, 20, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 24
In situ reporter (knock in) 8
Northern blot 12
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(15) Genomic(1) cDNA(13) Other(1)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000015138 (Evidence)
Ensembl Gene ModelENSMUSG00000050199 (Evidence)
Entrez Gene107515 (Evidence)
DFCITC1583322, TC1606415, TC1627511, TC1691306
DoTSDT.40164921, DT.91378703, DT.91561062
NIA Mouse Gene IndexU002223
Consensus CDS ProjectCCDS38195.1
International Mouse Knockout Project StatusLgr4
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015138 VEGA Gene Model | MGI Sequence Detail 96611 C57BL/6J ±  kb
transcript OTTMUST00000035907 VEGA | MGI Sequence Detail 5060 Not Applicable 
polypeptide OTTMUSP00000016116 VEGA | MGI Sequence Detail 951 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(579 from dbSNP Build 137)
InterPro IPR002131 Glycoprotein hormone receptor
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000001591 leucine-rich repeat-containing G-protein coupled receptor 4
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:208298 Wang J, et al., Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch. Nat Cell Biol. 2013 Dec;15(12):1455-63
All references(72)
accession IDs
MGI:1925178, MGI:2441840

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory