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Lgr4 Gene Detail
Summary
  • Symbol
    Lgr4
  • Name
    leucine-rich repeat-containing G protein-coupled receptor 4
  • Synonyms
    A330106J01Rik, A930009A08Rik, Gpr48
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891468
    NCBI Gene: 107515
  • Gene Overview
    MyGene.info: LGR4
Location & Maps
more
  • Sequence Map
    Chr2:109917647-110014257 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      96611 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 56.65 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LGR4, leucine rich repeat containing G protein-coupled receptor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LGR4, leucine rich repeat containing G protein-coupled receptor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BNMD17, GPR48
  • Links
    NCBI Gene ID: 55366
    neXtProt AC: NX_Q9BXB1

  • Chr Location
    11p14-p13; chr11:27365961-27472787 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    97 phenotypes from 6 alleles in 9 genetic backgrounds
    14 phenotypes from multigenic genotypes
    4 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    93
  • Chemically induced (other)
    1
  • Gene trapped
    84
  • Radiation induced
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Lgr4
  • Incidental Mutations
Homozygotes for a knock-out allele show embryonic and perinatal death, open eyelids, and abnormal renal development. One gene trap mutation leads to reduced body weight, sterility, and impaired male reproductive tract development. Another gene trap mutation causes ocular anterior segment anomalies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015138 VEGA Gene Model | MGI Sequence Detail 96611 C57BL/6J ±  kb
transcript OTTMUST00000035907 VEGA | MGI Sequence Detail 5060 Not Applicable  
polypeptide OTTMUSP00000016116 VEGA | MGI Sequence Detail 951 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    576 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001591 leucine-rich repeat-containing G-protein coupled receptor 4
  • InterPro Domains
    IPR002131 Glycoprotein hormone receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 19
    Genomic 1
    cDNA 14
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1925178, MGI:2441840
References
more
  • Summaries
    All 80
    Developmental Gene Expression 23
    Gene Ontology 12
    Phenotypes 51
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:231699 Voutilainen M, et al., Ectodysplasin/NF-kappaB Promotes Mammary Cell Fate via Wnt/beta-catenin Pathway. PLoS Genet. 2015 Nov;11(11):e1005676

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory