Lgr4
Gene Detail

Symbol Name ID

Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 MGI:1891468

Synonyms

A330106J01Rik, A930009A08Rik, Gpr48

Feature Type

protein coding gene

Genetic Map

Chromosome 2

56.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:109917647-110014257 bp, + strand From VEGA annotation of GRCm38   96611 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10226  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: leucine-rich repeat-containing G protein-coupled receptor 4/5/6
Gene Tree: Lgr4

Human homologs

Human Homolog		LGR4, leucine-rich repeat containing G protein-coupled receptor 4
NCBI Gene ID		55366
neXtProt AC		NX_Q9BXB1
Human Synonyms		GPR48
Human Chr (Location)		11p14-p13; chr11:27387508-27494334 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LGR4

Alleles and phenotypes

All alleles(89) : Targeted(5) Gene trapped(84)
 

Homozygotes for a knock-out allele show embryonic and perinatal death, open eyelids, and abnormal renal development. One gene trap mutation leads to reduced body weight, sterility, and impaired male reproductive tract development. Another gene trap mutation causes ocular anterior segment anomalies.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	canonical Wnt receptor signaling pathway involved in metanephric kidney development, cell differentiation involved in metanephros development, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, protein-hormone receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (36)    Tissues (27)    Images (2)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	24
Northern blot	12

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(1) cDNA(13) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000015138 (Evidence)
Ensembl Gene Model	ENSMUSG00000050199 (Evidence)
Entrez Gene	107515 (Evidence)
DFCI	TC1583322, TC1606415, TC1627511, TC1691306
DoTS	DT.40164921, DT.91378703, DT.91561062
NIA Mouse Gene Index	U002223
Consensus CDS Project	CCDS38195.1
International Mouse Knockout Project Status	Lgr4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015138	VEGA Gene Model | MGI Sequence Detail	96611	C57BL/6J
transcript	OTTMUST00000035907	VEGA | MGI Sequence Detail	5060	Not Applicable
polypeptide	OTTMUSP00000016116	VEGA | MGI Sequence Detail	951	Not Applicable

All sequences(47) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(463 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002131	Glycoprotein hormone receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000001591	leucine-rich repeat-containing G-protein coupled receptor 4

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:195273 Qian Y, et al., Lgr4-mediated Wnt/beta-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development. 2013 Apr;140(8):1751-61
All references(63)

Other accession IDs

MGI:1925178, MGI:2441840