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Gene trapped Allele Detail
Symbol: Lgr4Gt(LST020)Byg
Name: leucine-rich repeat-containing G protein-coupled receptor 4; gene trap LST020, BayGenomics
MGI ID: MGI:3790207
Synonyms: Gpr48, Gpr48-, Gpr68-, Lgr4m
Gene: Lgr4  Location: Chr2:109747992-109844602 bp, + strand  Genetic Position: Chr2, 56.65 cM
Alliance: Lgr4Gt(LST020)Byg page
Microphthalmia, iris hypoplasia, and iridiocorneal abnormalities in Lgr4Gt(LST020)Byg/Lgr4Gt(LST020)Byg mice

Show the 4 phenotype image(s) involving this allele.

Mutant Cell Line:  LST020
Germline Transmission:  Earliest citation of germline transmission: J:134299
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Gene trapped (Null/knockout)
Mutation:    Insertion of gene trap vector     Vector: pGT2TMpfs     Vector Type: secretory trap
Mutation detailsThe gene trap vector pGT2TMpfs (contains a CD4 transmembrane domain, beta-geo cassette, IRES and PLAP reporter) was inserted into intron 1. The absence of full-length transcript was confirmed by RT-PCR on E12.5 embryo extracts. (J:134299)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 49 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr4 Mutation:  82 strains or lines available
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
Original:  J:134299 Weng J, et al., Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2. Proc Natl Acad Sci U S A. 2008 Apr 22;105(16):6081-6
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory