Pcdhac2 MGI Mouse Gene Detail - MGI:1891443 - protocadherin alpha subfamily C, 2

Symbol

Pcdhac2
Name

protocadherin alpha subfamily C, 2
Synonyms

CNRc2

Feature Type

protein coding gene
IDs

MGI:1891443
NCBI Gene: 353237
Member of

Pcdha cluster
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr18:37276731-37320716 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 19.46 cM
Mapping Data

1 experiment

SNPs within 2kb

1137 from dbSNP Build 142
Strain Annotations

7

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891443	protein coding gene	Chr18:37276556-37320716 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0022156	protein coding gene	Chr18:34391800-34436126 (+)
CAST/EiJ	ENSTCUG00005020861	protein coding gene	Chr18:33880808-34073962 (+)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
JF1/MsJ	ENSUMUG00000043053	protein coding gene	Chr18:34345624-34538990 (+)
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	ENSLUMG00010012595	protein coding gene	Chr18:34508162-34700646 (+)
SPRET/EiJ	ENSMSPG00010021287	protein coding gene	Chr18:34536435-34761812 (+)
WSB/EiJ	ENSIUOG00005006670	protein coding gene	Chr18:33978242-34178355 (+)

Human Ortholog

PCDHAC2, protocadherin alpha subfamily C, 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PCDHAC2, protocadherin alpha subfamily C, 2
Synonyms

PCDH-ALPHA-C2
Links

HGNC:8677

NCBI Gene ID: 56134

UniProt: Q9Y5I4
Chr Location

5q31.3; chr5:140966470-141012347 (+) GRCh38

MGI Vertebrate Homology

Pcdhac2 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: PCDHAC2
Gene Tree

Pcdhac2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

All Mutations and Alleles

8
Endonuclease-mediated

1
Targeted

5
Transgenic

2
Genomic Mutations

5 involving Pcdhac2
Incidental Mutations

CvDC
Find Mice (IMSR)

31 strains or lines available

Mice homozygous for a reporter allele are viable and fertile with no apparent gross phenotype.

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

607
Tissues

4
cDNA Data

2
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pcdhac2

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All Sequences

16
RefSeq

2
UniProt

2
CCDS

CCDS29168.1

Ensembl

ENSMUSG00000102697 (Evidence)
NCBI Gene

353237

			Length	Strain/Species	Flank
genomic	353237	NCBI Gene Model \| MGI Sequence Detail	43986	C57BL/6J	± kb
transcript	NM_001003672	RefSeq \| MGI Sequence Detail	5719	C57BL/6
polypeptide	NP_001003672	RefSeq \| MGI Sequence Detail	1006	C57BL/6

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UniProt

2 Sequences
PDB

4ZPM
InterPro Domains

IPR020894 Cadherin conserved site

IPR031904 Cadherin, C-terminal catenin-binding domain

IPR032455 Cadherin, cytoplasmic C-terminal domain

IPR002126 Cadherin-like

IPR015919 Cadherin-like superfamily

IPR013164 Cadherin, N-terminal

IPR050174 Protocadherin/Cadherin-related Cell Adhesion
GlyGen

Q91Y09 7 sites, 5 N-linked glycans (5 sites)

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All nucleic 5

cDNA 2

Primer pair 3

Antibodies 1

Summaries

All 34

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 8
Earliest

J:86878 Wu Q, et al., A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90
Latest

J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766

TSS for Pcdhac2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150691	Chr18:37276717-37276749 (+)	2 bp
Tssr150692	Chr18:37276767-37276782 (+)	44 bp
Tssr150693	Chr18:37319748-37319749 (+)	43,018 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24