Foxp3
Gene Detail

Symbol Name ID

Foxp3 forkhead box P3 MGI:1891436

Synonyms

JM2, scurfin

Feature Type

protein coding gene

Genetic Map

Chromosome X

3.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

ChrX:7579676-7595243 bp, + strand From VEGA annotation of GRCm38   15568 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Foxp3

Human homologs

Human Homolog		FOXP3, forkhead box P3
NCBI Gene ID		50943
neXtProt AC		NX_Q9BZS1
Human Synonyms		AIID, DIETER, IPEX, PIDX, XPID
Human Chr (Location)		Xp11.23; chrX:49106897-49121288 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FOXP3

Alleles and phenotypes

All alleles(27) : Targeted(25) Spontaneous(1) Chemically induced(1)
 

Hemizygous mutant males exhibit scaly skin, reddening and swelling of genital papilla, small undescended testes, depressed platelet and red cell counts, and lymphohistiocytic proliferation in various organs. Mutants die around weaning age.

 
Human Diseases Modeled Using Mouse Foxp3 (3)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (116 annotations)

Process	B cell homeostasis, CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation, ...
Component	cytoplasm, intracellular, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (216)    Tissues (162)    Images (22)
Theiler Stages: 17, 18, 19, 21, 22, 23, 28

Assay Type	Results
RNA in situ	216

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(10)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016624 (Evidence)
Ensembl Gene Model	ENSMUSG00000039521 (Evidence)
Entrez Gene	20371 (Evidence)
PDB	4I1L
Consensus CDS Project	CCDS29965.1
International Mouse Knockout Project Status	Foxp3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016624	VEGA Gene Model | MGI Sequence Detail	15568	C57BL/6J
transcript	OTTMUST00000040205	VEGA | MGI Sequence Detail	3832	Not Applicable
polypeptide	OTTMUSP00000017952	VEGA | MGI Sequence Detail	429	Not Applicable

All sequences(39) RefSeq(6) UniProt(2)

Polymorphisms

SNPs(51 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix DNA-binding domain
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000001350	forkhead box protein P3

References

(Earliest) J:13126 Russell WL, et al., Exceptional inheritance of a sex-linked gene in the mouse explained on the basis that the X/O sex-chromosome constitution is female. Proc Natl Acad Sci U S A. 1959 Apr;45(4):554-560
(Latest) J:196144 Paiva RS, et al., Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6494-9
All references(519)

Other accession IDs

MGD-MRK-14368, MGI:98281