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Foxp3
Gene Detail
Symbol

Name
ID
Foxp3
forkhead box P3
MGI:1891436
Synonyms
JM2, scurfin
Feature Type
protein coding gene
Genetic Map
Chromosome X
3.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
ChrX:7579676-7595243 bp, + strand
From VEGA annotation of GRCm38

  15568 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Foxp3

Human
homologs
Human Homolog FOXP3, forkhead box P3
NCBI Gene ID 50943
neXtProt AC  NX_Q9BZS1
Human Synonyms  AIID, DIETER, IPEX, PIDX, XPID
Human Chr (Location)  Xp11.23; chrX:49250436-49265738 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human FOXP3
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(25)
Incidental mutations (data from Mutagenetix , APF )
 
Hemizygous mutant males exhibit scaly skin, reddening and swelling of genital papilla, small undescended testes, depressed platelet and red cell counts, and lymphohistiocytic proliferation in various organs. Mutants die around weaning age.
 
Human Diseases Modeled Using Mouse Foxp3 (3)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Foxp3 interacts with 256 markers (Mir1b, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (216)    Tissues (171)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 216
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016624 (Evidence)
Ensembl Gene ModelENSMUSG00000039521 (Evidence)
Entrez Gene20371 (Evidence)
PDB4I1L
Consensus CDS ProjectCCDS29965.1
International Mouse Knockout Project StatusFoxp3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016624 VEGA Gene Model | MGI Sequence Detail 15568 C57BL/6J ±  kb
transcript OTTMUST00000040222 VEGA | MGI Sequence Detail 3681 Not Applicable 
polypeptide OTTMUSP00000017962 VEGA | MGI Sequence Detail 429 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000001350 forkhead box protein P3
References
(Earliest) J:13126 Russell WL, et al., Exceptional inheritance of a sex-linked gene in the mouse explained on the basis that the X/O sex-chromosome constitution is female. Proc Natl Acad Sci U S A. 1959 Apr;45(4):554-560
(Latest) J:214814 Ganguly S, et al., Donor CD4+ Foxp3+ regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice. Blood. 2014 Sep 25;124(13):2131-41
All references(642)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-14368, MGI:98281

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory