Lpin2
Gene Detail

Symbol Name ID

Lpin2 lipin 2 MGI:1891341

Synonyms

2610511G02Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 17

41.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:71182560-71249817 bp, + strand From VEGA annotation of GRCm38   67258 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8769  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Lpin2

Human homologs

Human Homolog		LPIN2, lipin 2
NCBI Gene ID		9663
neXtProt AC		NX_Q92539
Human Chr (Location)		18p11.31; chr18:2916992-3011945 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LPIN2

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	dephosphorylation, fatty acid metabolic process, ...
Component	cytoplasm, cytosol, ...
Function	hydrolase activity, phosphatidate phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (20)    Tissues (15)   
Theiler Stages: 15, 19, 22, 24, 26, 28

Assay Type	Results
RNA in situ	20

cDNA source data(149)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(152) cDNA(151) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000024753 (Evidence)
Ensembl Gene Model	ENSMUSG00000024052 (Evidence)
Entrez Gene	64898 (Evidence)
UniGene	227924
DFCI	TC1577310, TC1589698, TC1599612, TC1610344, TC1610963, TC1617301
DoTS	DT.101174051, DT.101208955, DT.101355362, DT.101387183, DT.50315551, DT.55201229, DT.94131942, DT.94183114, DT.94261089, DT.97349798
EC	3.1.3.4
Consensus CDS Project	CCDS28956.1, CCDS50177.1
International Mouse Knockout Project Status	Lpin2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024753	VEGA Gene Model | MGI Sequence Detail	67258	C57BL/6J
transcript	OTTMUST00000060991	VEGA | MGI Sequence Detail	4167	Not Applicable
polypeptide	OTTMUSP00000029837	VEGA | MGI Sequence Detail	931	Not Applicable

All sequences(89) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(82 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023214	HAD-like domain
InterPro	IPR026058	LIPIN family
InterPro	IPR007651	Lipin, N-terminal
InterPro	IPR013209	LNS2, Lipin/Ned1/Smp2
InterPro	IPR026744	Phosphatidate phosphatase LPIN2
Protein Ontology	PR:000009895	lipin-2

References

(Earliest) J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
(Latest) J:189894 Dwyer JR, et al., Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2486-95
All references(33)

Other accession IDs

MGI:1915262, MGI:2146881, MGI:2147099