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Lpin2 Gene Detail
Summary
  • Symbol
    Lpin2
  • Name
    lipin 2
  • Synonyms
    2610511G02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891341
    NCBI Gene: 64898
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:71183527-71249818 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 41.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    236 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891341
protein coding gene Chr17:71182560-71249818 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024005
protein coding gene Chr17:73616048-73686027 (+)
A/J MGP_AJ_G0023963
protein coding gene Chr17:71381711-71457305 (+)
AKR/J MGP_AKRJ_G0023932
protein coding gene Chr17:72355879-72422615 (+)
BALB/cJ MGP_BALBcJ_G0023964
protein coding gene Chr17:71288942-71356730 (+)
C3H/HeJ MGP_C3HHeJ_G0023728
protein coding gene Chr17:73311135-73381887 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024410
protein coding gene Chr17:76299546-76371339 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021855
protein coding gene Chr17:67152421-67216929 (+)
CAST/EiJ MGP_CASTEiJ_G0023209
protein coding gene Chr17:73735662-73809529 (+)
CBA/J MGP_CBAJ_G0023703
protein coding gene Chr17:79475275-79548141 (+)
DBA/2J MGP_DBA2J_G0023832
protein coding gene Chr17:70055328-70123360 (+)
FVB/NJ MGP_FVBNJ_G0023798
protein coding gene Chr17:69521642-69589322 (+)
LP/J MGP_LPJ_G0023914
protein coding gene Chr17:74370514-74441991 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023826
protein coding gene Chr17:79344122-79416172 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024454
protein coding gene Chr17:72870153-72938213 (+)
PWK/PhJ MGP_PWKPhJ_G0022955
protein coding gene Chr17:69358884-69425244 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022766
protein coding gene Chr17:69587750-69654441 (+)
WSB/EiJ MGP_WSBEiJ_G0023276
protein coding gene Chr17:73691155-73760248 (+)



Homology
more
  • Human Ortholog
    LPIN2, lipin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPIN2, lipin 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9663
    neXtProt AC: NX_Q92539
    UniProt: Q92539

  • Chr Location
    18p11.31; chr18:2916994-3013315 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8769
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LPIN2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice develop ataxia, impaired blance, and tremors with age and show altered cerebellar phospholipid composition and anemia. Mice show diet-induced hepatic triglyceride accumulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64898 NCBI Gene Model | MGI Sequence Detail 66292 C57BL/6J ±  kb
    transcript NM_001164885 RefSeq | MGI Sequence Detail 5775 C57BL/6  
    polypeptide Q99PI5 UniProt | EBI | MGI Sequence Detail 893 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 152
      cDNA 151
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915262, MGI:2146881, MGI:2147099
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
    • Latest
      J:259186 Heng X, et al., Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Elife. 2017 May 10;6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory