Sequence Detail

ID/Version

Q99PI5 Q8C357 Q8CC85 Q8C7I8 Q8CHR7 (UniProt | EBI)

Last sequence update: 2004-05-24
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Phosphatidate phosphatase LPIN2 {ECO:0000305}; EC=3.1.3.4 {ECO:0000269|PubMed:17158099};AltName: Full=Lipin-2 {ECO:0000303|PubMed:19717560};

Provider

SWISS-PROT

Sequence

Polypeptide 893 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lpin2	lipin 2	18	98	3	7

Sequence references in MGI

J:66739 Peterfy M, et al., Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet. 2001 Jan;27(1):121-4
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:120935 Donkor J, et al., Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. J Biol Chem. 2007 Feb 9;282(6):3450-7
J:148371 Gropler MC, et al., Lipin 2 is a liver-enriched phosphatidate phosphohydrolase enzyme that is dynamically regulated by fasting and obesity in mice. J Biol Chem. 2009 Mar 13;284(11):6763-72
J:156973 Donkor J, et al., A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2. J Biol Chem. 2009 Oct 23;284(43):29968-78
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89