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Ctsz
Gene Detail
 Symbol
Name
ID
Ctsz
cathepsin Z
MGI:1891190
Synonyms cathepsin X, CTSX, D2Wsu143e
Feature Type protein coding gene
Genetic Map
Chromosome 2
97.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:174427493-174439039 bp, - strand
From VEGA annotation of GRCm38

  11547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1022  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ctsz

Human
homologs
Human Homolog CTSZ, cathepsin Z
NCBI Gene ID 1522
neXtProt AC  NX_Q9UBR2
Human Synonyms  CTSX
Human Chr (Location)  20q13.32; chr20:58995187-59007254 (-)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(3) Gene trapped(1)
 
No abnormal pheotype detected in homozygous mutant mice.
 
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process proteolysis
Component endoplasmic reticulum, extracellular space, ...
Function cysteine-type peptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (10)    Tissues (5)    Images (3)
Theiler Stages: 7, 9, 11, 15
Assay TypeResults
RNA in situ 2
RT-PCR 8
cDNA source data(202)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(205) Genomic(1) cDNA(202) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016461 (Evidence)
Ensembl Gene ModelENSMUSG00000016256 (Evidence)
Entrez Gene64138 (Evidence)
UniGene156919
DFCITC1573931
DoTSDT.103566389, DT.494833, DT.91398862, DT.97340664
NIA Mouse Gene IndexU023740
EC3.4.18.1
Consensus CDS ProjectCCDS17152.1
International Mouse Knockout Project StatusCtsz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016461 VEGA Gene Model | MGI Sequence Detail 11547 C57BL/6J ±  kb
transcript OTTMUST00000039661 VEGA | MGI Sequence Detail 1441 Not Applicable 
polypeptide OTTMUSP00000017701 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(185 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025661 Cysteine peptidase, asparagine active site
InterPro IPR013128 Peptidase C1A, papain
InterPro IPR000668 Peptidase C1A, papain C-terminal
Protein Ontology PR:000006035 cathepsin Z
References (Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:203265 Krueger S, et al., Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice. PLoS One. 2013;8(7):e70242
All references(45)
Other
accession IDs
MGD-MRK-35814, MGI:107348, MGI:2139048, MGI:2139182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory