Ctsz
Gene Detail

Symbol Name ID

Ctsz cathepsin Z MGI:1891190

Synonyms

cathepsin X, CTSX, D2Wsu143e

Feature Type

protein coding gene

Genetic Map

Chromosome 2

97.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:174427493-174439039 bp, - strand From VEGA annotation of GRCm38   11547 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1022  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ctsz

Human homologs

Human Homolog		CTSZ, cathepsin Z
NCBI Gene ID		1522
neXtProt AC		NX_Q9UBR2
Human Synonyms		CTSX
Human Chr (Location)		20q13.32; chr20:57570242-57582309 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

No abnormal pheotype detected in homozygous mutant mice.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	proteolysis
Component	endoplasmic reticulum, extracellular space, ...
Function	cysteine-type peptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (10)    Tissues (5)    Images (3)
Theiler Stages: 7, 9, 11, 15

Assay Type	Results
RNA in situ	2
RT-PCR	8

cDNA source data(200)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(203) Genomic(1) cDNA(200) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016461 (Evidence)
Ensembl Gene Model	ENSMUSG00000016256 (Evidence)
Entrez Gene	64138 (Evidence)
UniGene	156919
DFCI	TC1573931
DoTS	DT.494833, DT.103566389, DT.91398862, DT.97340664
NIA Mouse Gene Index	U023740
EC	3.4.18.1
Consensus CDS Project	CCDS17152.1
International Mouse Knockout Project Status	Ctsz

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016461	VEGA Gene Model | MGI Sequence Detail	11547	C57BL/6J
transcript	OTTMUST00000039661	VEGA | MGI Sequence Detail	1441	Not Applicable
polypeptide	OTTMUSP00000017701	VEGA | MGI Sequence Detail	306	Not Applicable

All sequences(59) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(145 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025661	Cysteine peptidase, asparagine active site
InterPro	IPR013128	Peptidase C1A, papain
InterPro	IPR000668	Peptidase C1A, papain C-terminal
Protein Ontology	PR:000006035	cathepsin Z

References

(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:177067 Zhang B, et al., Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of {alpha}1-antitrypsin. Blood. 2011 Sep 22;118(12):3384-91
All references(44)

Other accession IDs

MGD-MRK-35814, MGI:107348, MGI:2139048, MGI:2139182