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Ctsz
Gene Detail
Symbol

Name
ID
Ctsz
cathepsin Z
MGI:1891190
Synonyms
cathepsin X, CTSX, D2Wsu143e
Feature Type
protein coding gene
Genetic Map
Chromosome 2
97.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:174427493-174439039 bp, - strand
From VEGA annotation of GRCm38

  11547 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1022  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CTSZ
Gene Tree: Ctsz

Human
homologs
CTSZ, cathepsin Z
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1522
neXtProt AC: NX_Q9UBR2

Human Synonyms: CTSX

Human Chr (Location): 20q13.32; chr20:58995187-59007254 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from APF )
 
No abnormal pheotype detected in homozygous mutant mice.
 
Interactions
Ctsz interacts with 59 markers (Mir24-1, Mir24-2, Mir27a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (10)    Tissues (5)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
RT-PCR 8
cDNA source data(202)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ctsz ; ZFIN ctsz    NEW 
Molecular
reagents
All nucleic(205) Genomic(1) cDNA(202) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016461 (Evidence)
Ensembl Gene Model ENSMUSG00000016256 (Evidence)
Entrez Gene 64138 (Evidence)
UniGene 156919
DFCI TC1573931
DoTS DT.91398862, DT.494833, DT.97340664, DT.103566389
NIA Mouse Gene Index U023740
EC 3.4.18.1
Consensus CDS Project CCDS17152.1
International Mouse Phenotyping Consortium Status Ctsz
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016461 VEGA Gene Model | MGI Sequence Detail 11547 C57BL/6J ±  kb
transcript OTTMUST00000039661 VEGA | MGI Sequence Detail 1441 Not Applicable 
polypeptide OTTMUSP00000017701 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(185 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025661 Cysteine peptidase, asparagine active site
InterPro IPR013128 Peptidase C1A, papain
InterPro IPR000668 Peptidase C1A, papain C-terminal
Protein Ontology PR:000006035 cathepsin Z
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:217440 Akkari L, et al., Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. Genes Dev. 2014 Oct 1;28(19):2134-50
All references(49)
Other
accession IDs
MGD-MRK-35814, MGI:107348, MGI:2139048, MGI:2139182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory