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Ctsz Gene Detail
Summary
  • Symbol
    Ctsz
  • Name
    cathepsin Z
  • Synonyms
    cathepsin X, CTSX, D2Wsu143e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891190
    NCBI Gene: 64138
  • Gene Overview
    MyGene.info: CTSZ
Location & Maps
more
  • Sequence Map
    Chr2:174427493-174439039 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11547 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 97.94 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CTSZ, cathepsin Z
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CTSZ, cathepsin Z
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTSX
  • Links
    NCBI Gene ID: 1522
    neXtProt AC: NX_Q9UBR2

  • Chr Location
    20q13.32; chr20:58995187-59007254 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1022
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CTSZ
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    10 phenotype references
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    3
  • Incidental Mutations
    APF
No abnormal pheotype detected in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016461 VEGA Gene Model | MGI Sequence Detail 11547 C57BL/6J ±  kb
transcript OTTMUST00000039661 VEGA | MGI Sequence Detail 1441 Not Applicable  
polypeptide OTTMUSP00000017701 VEGA | MGI Sequence Detail 306 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    176 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 205
    Genomic 1
    cDNA 202
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-35814, MGI:107348, MGI:2139048, MGI:2139182
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:229457 Akkari L, et al., Combined deletion of cathepsin protease family members reveals compensatory mechanisms in cancer. Genes Dev. 2016 Jan 15;30(2):220-32

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory