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Nek7 Gene Detail
Summary
  • Symbol
    Nek7
  • Name
    NIMA (never in mitosis gene a)-related expressed kinase 7
  • Synonyms
    2810460C19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890645
    NCBI Gene: 59125
Location & Maps
more
  • Sequence Map
    Chr1:138482875-138620141 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      137267 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 60.82 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NEK7, NIMA related kinase 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEK7, NIMA related kinase 7
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 140609
    neXtProt AC: NX_Q8TDX7

  • Chr Location
    1q31.3; chr1:198156978-198322420 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 5 alleles in 5 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    35
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    27
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    3 involving Nek7
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit infertility, decreased susceptibility to EAE, decreased body weight, abnormal gait, slight parasis and abnormal immune system response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049434 VEGA Gene Model | MGI Sequence Detail 137267 C57BL/6J ±  kb
transcript OTTMUST00000126020 VEGA | MGI Sequence Detail 4336 Not Applicable  
polypeptide OTTMUSP00000068194 VEGA | MGI Sequence Detail 302 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1030 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011133 serine/threonine-protein kinase Nek7
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
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  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1920061, MGI:1921017, MGI:2138456
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:58906 Kandli M, et al., Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96
  • Latest
    J:229240 He Y, et al., NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. 2016 Feb 18;530(7590):354-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory