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Nek7
Gene Detail
Symbol

Name
ID
Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
MGI:1890645
Synonyms
2810460C19Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
60.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:138483837-138620218 bp, - strand
From VEGA annotation of GRCm38

  136382 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69340  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Nek7

Human
homologs
Human Homolog NEK7, NIMA-related kinase 7
NCBI Gene ID 140609
neXtProt AC  NX_Q8TDX7
Human Chr (Location)  1q31.3; chr1:198156978-198322420 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(27) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null allele leads to lethality in late embryogenesis or at early post-natal stages and to severe growth retardation.
 
Interactions
Nek7 interacts with 293 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process phosphorylation, protein phosphorylation
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (207)    Tissues (183)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 196
Northern blot 11
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049434 (Evidence)
Ensembl Gene ModelENSMUSG00000026393 (Evidence)
Entrez Gene59125 (Evidence)
DFCITC1610750, TC1575001
DoTSDT.99870212, DT.55101159
NIA Mouse Gene IndexU021831
EC2.7.11.1
Consensus CDS ProjectCCDS15332.1
International Mouse Knockout Project StatusNek7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049434 VEGA Gene Model | MGI Sequence Detail 136382 C57BL/6J ±  kb
transcript OTTMUST00000126019 VEGA | MGI Sequence Detail 4296 Not Applicable 
polypeptide OTTMUSP00000068193 VEGA | MGI Sequence Detail 302 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(1027 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1031)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000011133 serine/threonine-protein kinase Nek7
References
(Earliest) J:58906 Kandli M, et al., Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(44)
Other
accession IDs
MGI:1920061, MGI:1921017, MGI:2138456

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory