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Nek7
Gene Detail
 Symbol
Name
ID
Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
MGI:1890645
Synonyms 2810460C19Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
60.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:138484714-138619696 bp, - strand
From NCBI annotation of GRCm38

  134983 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69340  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Nek7

Human
homologs
Human Homolog NEK7, NIMA-related kinase 7
NCBI Gene ID 140609
neXtProt AC  NX_Q8TDX7
Human Chr (Location)  1q31.3; chr1:198156978-198322420 (+)  GRCh38
Alleles
and
phenotypes
All alleles(30) : Gene trapped(27) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for null allele leads to lethality in late embryogenesis or at early post-natal stages and to severe growth retardation.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process phosphorylation, protein phosphorylation
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (207)    Tissues (183)    Images (46)
Theiler Stages: 9, 15, 17, 18, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 196
Northern blot 11
cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000026393 (Evidence)
Entrez Gene59125 (Evidence)
DFCITC1575001, TC1610750
DoTSDT.55101159, DT.99870212
NIA Mouse Gene IndexU021831
EC2.7.11.1
Consensus CDS ProjectCCDS15332.1
International Mouse Knockout Project StatusNek7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 59125 NCBI Gene Model | MGI Sequence Detail 134983 C57BL/6J ±  kb
transcript NM_021605 RefSeq | MGI Sequence Detail 3366 C57BL/6 
polypeptide Q9ES74 UniProt | EBI | MGI Sequence Detail 302 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(1014 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1018)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000011133 serine/threonine-protein kinase Nek7
Graphical View of Protein Domain Structure
References (Earliest) J:58906 Kandli M, et al., Isolation and characterization of two evolutionarily conserved murine kinases (Nek6 and nek7) related to the fungal mitotic regulator, NIMA. Genomics. 2000 Sep 1;68(2):187-96
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(42)
Other
accession IDs
MGI:1920061, MGI:1921017, MGI:2138456

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory