Nek7 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nek7
NIMA (never in mitosis gene a)-related expressed kinase 7
MGI:1890645

25 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nek7^{Gt(AR1081)Wtsi}/Nek7^{Gt(AR1081)Wtsi} involves: 129P2/OlaHsd	normal vision/eye phenotype	J:180113
Nek7^{Gt(NPX451)Byg}/Nek7^{Gt(NPX451)Byg} involves: 129P2/OlaHsd	normal vision/eye phenotype	J:180113
Nek7^M1Btlr/Nek7⁺ C57BL/6J-Nek7^M1Btlr	abnormal macrophage physiology	J:226677
	decreased inflammatory response	J:226677
	decreased interleukin-1 beta secretion	J:226677
	decreased interleukin-18 secretion	J:226677
	normal hematopoietic system phenotype	J:226677
	normal immune system phenotype	J:226677
Nek7^M1Btlr/Nek7^M1Btlr C57BL/6J-Nek7^M1Btlr	abnormal gait	J:226677
	abnormal macrophage physiology	J:226677
	decreased body weight	J:226677
	decreased inflammatory response	J:226677
	decreased interleukin-1 beta secretion	J:226677
	decreased interleukin-18 secretion	J:226677
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:226677
	normal hematopoietic system phenotype	J:226677
	normal immune system phenotype	J:226677
	infertility	J:226677
	paresis	J:226677
Nek7^{tm1b(EUCOMM)Hmgu}/Nek7⁺ C57BL/6N-Nek7^{tm1b(EUCOMM)Hmgu}/J	increased urine microalbumin level	J:211773
Nek7^{tm1b(EUCOMM)Hmgu}/Nek7^{tm1b(EUCOMM)Hmgu} C57BL/6N-Nek7^{tm1b(EUCOMM)Hmgu}/J	preweaning lethality, complete penetrance	J:211773
Nek7^tm1Mot/Nek7^tm1Mot involves: 129S1/Sv * 129X1/SvJ	normal vision/eye phenotype	J:180113
Nek7^tm1Mot/Nek7^tm1Mot involves: 129S1/Sv * 129X1/SvJ * BALB/c * ICR	abnormal mitosis	J:168166
	aneuploidy	J:168166
	binucleate	J:168166
	chromosomal instability	J:168166
	decreased birth weight	J:168166
	embryonic lethality during organogenesis, incomplete penetrance	J:168166
	lethality throughout fetal growth and development, incomplete penetrance	J:168166
	perinatal lethality, incomplete penetrance	J:168166
	polyploidy	J:168166
	postnatal growth retardation	J:168166
	postnatal lethality, incomplete penetrance	J:168166
	preweaning lethality, complete penetrance	J:168166

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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