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Abcg4 Gene Detail
Summary
  • Symbol
    Abcg4
  • Name
    ATP binding cassette subfamily G member 4
  • Synonyms
    6430517O04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890594
    NCBI Gene: 192663
  • Gene Overview
    MyGene.info: ABCG4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44273188-44288615 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband A5.3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890594
protein coding gene Chr9:44273188-44289102 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034698
protein coding gene Chr9:42749807-42764995 (-)
A/J MGP_AJ_G0034679
protein coding gene Chr9:41563655-41580753 (-)
AKR/J MGP_AKRJ_G0034605
protein coding gene Chr9:42424986-42440131 (-)
BALB/cJ MGP_BALBcJ_G0034670
protein coding gene Chr9:41309765-41325641 (-)
C3H/HeJ MGP_C3HHeJ_G0034381
protein coding gene Chr9:42873900-42892998 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035191
protein coding gene Chr9:44018681-44033816 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032106
protein coding gene Chr9:41145631-41160421 (-)
CAST/EiJ MGP_CASTEiJ_G0033703
protein coding gene Chr9:42716592-42732902 (-)
CBA/J MGP_CBAJ_G0034353
protein coding gene Chr9:45616719-45640499 (-)
DBA/2J MGP_DBA2J_G0034512
protein coding gene Chr9:41467760-41483441 (-)
FVB/NJ MGP_FVBNJ_G0034453
protein coding gene Chr9:40716679-40732832 (-)
LP/J MGP_LPJ_G0034593
protein coding gene Chr9:43047965-43062752 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034497
protein coding gene Chr9:47469460-47486267 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035212
protein coding gene Chr9:42320608-42336799 (-)
PWK/PhJ MGP_PWKPhJ_G0033409
protein coding gene Chr9:41339333-41354713 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033243
protein coding gene Chr9:42637524-42653367 (-)
WSB/EiJ MGP_WSBEiJ_G0033816
protein coding gene Chr9:42357424-42375651 (-)



Homology
more
  • Human Ortholog
    ABCG4, ATP binding cassette subfamily G member 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ABCG4, ATP binding cassette subfamily G member 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    WHITE2
  • Links
    NCBI Gene ID: 64137
    neXtProt AC: NX_Q9H172
    UniProt: Q9H172

  • Chr Location
    11q23.3; chr11:119149040-119162666 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 75179
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ABCG4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a report allele exhibit increased brain lathosterol levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032131 Ensembl Gene Model | MGI Sequence Detail 15428 C57BL/6J ±  kb
transcript ENSMUST00000034648 Ensembl | MGI Sequence Detail 3476 Not Applicable  
polypeptide ENSMUSP00000034648 Ensembl | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR013525 ABC-2 type transporter
    IPR017871 ABC transporter, conserved site
    IPR003439 ABC transporter-like
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 40
    cDNA 39
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924137
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:198517 Murphy AJ, et al., Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med. 2013 May;19(5):586-94

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory