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Rcan1
Gene Detail
Symbol

Name
ID
Rcan1
regulator of calcineurin 1
MGI:1890564
Synonyms
2410048A02Rik, ADAPT78, CSP1, Dscr1, MCIP1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
53.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:92391953-92466146 bp, - strand
From Ensembl annotation of GRCm38

  74194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3251  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: RCAN1
Gene Tree: Rcan1

Human
homologs
RCAN1, regulator of calcineurin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1827
neXtProt AC: NX_P53805

Human Synonyms: ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1

Human Chr (Location): 21q22.12; chr21:34516442-34615142 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(14) Targeted(11) Transgenic(1)
Genomic Mutations involving Rcan1 (5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Unstressed homozygous mutant mice show no overt phenotype other than a slight reduction in heart size and an impaired T helper 1 response. Stress-induced cardiac hypertrophy, however, is attenuated in mutant mice.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Rcan1 interacts with 144 markers (Mir17, Mir18, Mir20a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (319)    Tissues (203)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 277
Northern blot 12
RT-PCR 30
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RCAN1 ; Xenbase rcan1 ; ZFIN rcan1a    NEW 
Molecular
reagents
All nucleic(18) cDNA(14) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022951 (Evidence)
Entrez Gene 54720 (Evidence)
DFCI TC1576511, TC1593367, TC1608145
DoTS DT.101324175, DT.491636, DT.91447852, DT.94305465, DT.94305508
NIA Mouse Gene Index U037314
PDB 1WEY
Consensus CDS Project CCDS28337.1, CCDS37405.1
International Mouse Phenotyping Consortium Status Rcan1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022951 Ensembl Gene Model | MGI Sequence Detail 74194 C57BL/6J ±  kb
transcript ENSMUST00000060005 Ensembl | MGI Sequence Detail 2324 Not Applicable 
polypeptide ENSMUSP00000060394 Ensembl | MGI Sequence Detail 251 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(320 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006931 Calcipressin
Protein Ontology PR:000013829 calcipressin-1
References
(Earliest) J:61529 Strippoli P, et al., A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000 Mar 15;64(3):252-63
(Latest) J:220406 Ishihara K, et al., Comparative proteomic profiling reveals aberrant cell proliferation in the brain of embryonic Ts1Cje, a mouse model of Down syndrome. Neuroscience. 2014 Sep 28;281C:1-15
All references(71)
Other
accession IDs
MGI:1915204, MGI:2146336, MGI:2146431, MGI:2146530, MGI:2146591

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory