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Rcan1 Gene Detail
Summary
  • Symbol
    Rcan1
  • Name
    regulator of calcineurin 1
  • Synonyms
    2410048A02Rik, ADAPT78, CSP1, Dscr1, MCIP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890564
    NCBI Gene: 54720
  • Gene Overview
    MyGene.info: RCAN1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:92391953-92466146 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74194 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 53.60 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RCAN1, regulator of calcineurin 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    RCAN1, regulator of calcineurin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
  • Links
    NCBI Gene ID: 1827
    neXtProt AC: NX_P53805
    UniProt: P53805

  • Chr Location
    21q22.12; chr21:34516442-34615142 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 4 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Unstressed homozygous mutant mice show no overt phenotype other than a slight reduction in heart size and an impaired T helper 1 response. Stress-induced cardiac hypertrophy, however, is attenuated in mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022951 Ensembl Gene Model | MGI Sequence Detail 74194 C57BL/6J ±  kb
    transcript ENSMUST00000060005 Ensembl | MGI Sequence Detail 2324 Not Applicable  
    polypeptide ENSMUSP00000060394 Ensembl | MGI Sequence Detail 251 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      319 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 15
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915204, MGI:2146336, MGI:2146431, MGI:2146530, MGI:2146591
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 9
      Phenotypes 47
    • Earliest
      J:61529 Strippoli P, et al., A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000 Mar 15;64(3):252-63
    • Latest
      J:262949 Pang Z, et al., Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways. PLoS One. 2018;13(5):e0197491

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory