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Rcan1 Gene Detail
Summary
  • Symbol
    Rcan1
  • Name
    regulator of calcineurin 1
  • Synonyms
    2410048A02Rik, ADAPT78, CSP1, Dscr1, MCIP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890564
    NCBI Gene: 54720
  • Gene Overview
    MyGene.info: RCAN1
Location & Maps
more
  • Sequence Map
    Chr16:92391953-92466146 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74194 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 53.60 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RCAN1, regulator of calcineurin 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    RCAN1, regulator of calcineurin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
  • Links
    NCBI Gene ID: 1827
    neXtProt AC: NX_P53805

  • Chr Location
    21q22.12; chr21:34516442-34615142 (-)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 5 alleles in 4 genetic backgrounds
    26 phenotypes from multigenic genotypes
    1 images
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Gene trapped
    14
  • Targeted
    12
  • Transgenic
    1
  • Genomic Mutations
    6 involving Rcan1
  • Incidental Mutations
Unstressed homozygous mutant mice show no overt phenotype other than a slight reduction in heart size and an impaired T helper 1 response. Stress-induced cardiac hypertrophy, however, is attenuated in mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022951 Ensembl Gene Model | MGI Sequence Detail 74194 C57BL/6J ±  kb
transcript ENSMUST00000060005 Ensembl | MGI Sequence Detail 2324 Not Applicable  
polypeptide ENSMUSP00000060394 Ensembl | MGI Sequence Detail 251 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    319 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 14
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
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MGI:1915204, MGI:2146336, MGI:2146431, MGI:2146530, MGI:2146591
References
more
  • Summaries
    All 70
    Developmental Gene Expression 15
    Diseases 2
    Gene Ontology 7
    Phenotypes 43
  • Earliest
    J:61529 Strippoli P, et al., A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000 Mar 15;64(3):252-63
  • Latest
    J:233771 Chen HH, et al., NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration. J Cell Sci. 2015 Nov 15;128(22):4196-209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory