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Rcan1
Gene Detail
 Symbol
Name
ID
Rcan1
regulator of calcineurin 1
MGI:1890564
Synonyms 2410048A02Rik, ADAPT78, CSP1, Dscr1, MCIP1
Feature Type protein coding gene
Genetic Map
Chromosome 16
53.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:92391953-92466146 bp, - strand
From NCBI annotation of GRCm38

  74194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3251  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Rcan1

Human
homologs
Human Homolog RCAN1, regulator of calcineurin 1
NCBI Gene ID 1827
neXtProt AC  NX_P53805
Human Synonyms  ADAPT78, CSP1, DSC1, DSCR1, MCIP1, RCN1
Human Chr (Location)  21q22.12; chr21:34516442-34615142 (-)  GRCh38
Alleles
and
phenotypes
All alleles(19) : Gene trapped(14) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Unstressed homozygous mutant mice show no overt phenotype other than a slight reduction in heart size and an impaired T helper 1 response. Stress-induced cardiac hypertrophy, however, is attenuated in mutant mice.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process calcineurin-NFAT signaling cascade, calcium-mediated signaling, ...
Component cytoplasm, intracellular, ...
Function identical protein binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (319)    Tissues (195)    Images (48)
Theiler Stages: 10, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 277
Northern blot 12
RT-PCR 30
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(14) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022951 (Evidence)
Entrez Gene54720 (Evidence)
DFCITC1576511, TC1593367, TC1608145
DoTSDT.101324175, DT.491636, DT.91447852, DT.94305465, DT.94305508
NIA Mouse Gene IndexU037314
PDB1WEY
Consensus CDS ProjectCCDS28337.1, CCDS37405.1
International Mouse Knockout Project StatusRcan1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 54720 NCBI Gene Model | MGI Sequence Detail 74194 C57BL/6J ±  kb
transcript NM_001081549 RefSeq | MGI Sequence Detail 2349 C57BL/6 
polypeptide Q9JHG6 UniProt | EBI | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(320 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006931 Calcipressin
Protein Ontology PR:000013829 calcipressin-1
Graphical View of Protein Domain Structure
References (Earliest) J:61529 Strippoli P, et al., A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics. 2000 Mar 15;64(3):252-63
(Latest) J:207132 Wu Z, et al., Calcineurin-Rcan1 interaction contributes to stem cell factor-mediated mast cell activation. J Immunol. 2013 Dec 15;191(12):5885-94
All references(68)
Other
accession IDs
MGI:1915204, MGI:2146336, MGI:2146431, MGI:2146530, MGI:2146591

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory