Rcan1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Rcan1
regulator of calcineurin 1
MGI:1890564

24 phenotypes from 6 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hprt1^{tm1(Rcan1)Zyga}/Hprt1⁺ B6.129P2-Hprt1^{tm1(Rcan1)Zyga}	abnormal megakaryocyte progenitor cell morphology	J:197570
	decreased tumor growth/size	J:150286
	decreased vascular endothelial cell proliferation	J:150286
	increased megakaryocyte cell number	J:197570
	thrombocytosis	J:197570
Rcan1^{tm1b(KOMP)Wtsi}/Rcan1^{tm1b(KOMP)Wtsi} C57BL/6N-Rcan1^{tm1b(KOMP)Wtsi}/Ics	decreased total body fat amount	J:211773
	increased lean body mass	J:211773
Rcan1^tm1Emar/Rcan1^tm1Emar involves: 129P2/OlaHsd * C57BL/6	abnormal adrenal gland secretion	J:132495
	oxidative stress	J:132745
Rcan1^tm1Eno/Rcan1^tm1Eno involves: 129 * C57BL/6	abnormal heart morphology	J:81417
	decreased heart weight	J:81417
	decreased response of heart to induced stress	J:81417
Rcan1^tm1Fmc/Rcan1^tm1Fmc involves: 129S4/SvJae	abnormal circulating protein level	J:152536
	abnormal T cell apoptosis	J:85148
	abnormal T-helper 1 physiology	J:85148
	decreased IgG2a level	J:85148
	decreased interferon-gamma secretion	J:85148
	decreased T cell proliferation	J:85148
	increased susceptibility to endotoxin shock	J:152536
Rcan1^tm1Jmol/Rcan1^tm1Jmol involves: 129 * C57BL/6	abnormal myocardium layer morphology	J:109586
	abnormal response to cardiac infarction	J:109586
	decreased body weight	J:109586
	decreased response of heart to induced stress	J:109586
	increased heart weight	J:109586
	reduced fertility	J:109586

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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