Rcan1tm1Fmc
Targeted Allele Detail
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Symbol: |
Rcan1tm1Fmc |
Name: |
regulator of calcineurin 1; targeted mutation 1, Frank McKeon |
MGI ID: |
MGI:2674908 |
Synonyms: |
dscr1- |
Gene: |
Rcan1 Location: Chr16:92188839-92263057 bp, - strand Genetic Position: Chr16, 53.6 cM
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Alliance: |
Rcan1tm1Fmc page
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Increased inflammatory leukocyte infiltration in sepsis in Rcan1tm1Fmc/Rcan1tm1Fmc heart and lung
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:85148
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 6 was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of CD4+ T cells obtained from homozygous mutations.
(J:85148)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rcan1 Mutation: |
24 strains or lines available
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Original: |
J:85148 Ryeom S, et al., The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol. 2003 Sep;4(9):874-81 |
All: |
12 reference(s) |
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