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Elac2 Gene Detail
Summary
  • Symbol
    Elac2
  • Name
    elaC ribonuclease Z 2
  • Synonyms
    1110017O07Rik, D11Wsu80e, tRNase Z(L)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890496
    NCBI Gene: 68626
Location & Maps
more
  • Sequence Map
    Chr11:64979038-65002069 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23032 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ELAC2, elaC ribonuclease Z 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ELAC2, elaC ribonuclease Z 2
    Orthology source: HomoloGene
  • Synonyms
    COXPD17, ELC2, HPC2
  • Links
    NCBI Gene ID: 60528
    neXtProt AC: NX_Q9BQ52

  • Chr Location
    17p11.2; chr17:12991612-13018064 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human ELAC2 associations

Human Disease Mouse Models
       Combined Oxidative Phosphorylation Deficiency 17; COXPD17   OMIM: 615440
Prostate Cancer, Hereditary, 2; HPC2   OMIM: 614731
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    3
  • Genomic Mutations
    1 involving Elac2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005902 VEGA Gene Model | MGI Sequence Detail 23032 C57BL/6J ±  kb
transcript OTTMUST00000013128 VEGA | MGI Sequence Detail 2771 Not Applicable  
polypeptide OTTMUSP00000006092 VEGA | MGI Sequence Detail 831 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    178 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 80
    cDNA 79
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-34044, MGI:106352, MGI:1915876
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:213151 Bogenhagen DF, et al., Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Cell Metab. 2014 Apr 1;19(4):618-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory