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Il21 Gene Detail
Summary
  • Symbol
    Il21
  • Name
    interleukin 21
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890474
    NCBI Gene: 60505
  • Gene Overview
    MyGene.info: IL21
Location & Maps
more
  • Sequence Map
    Chr3:37222759-37232636 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9878 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 18.36 cM, cytoband B
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IL21, interleukin 21
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL21, interleukin 21
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CVID11, IL-21, Za11
  • Links
    NCBI Gene ID: 59067
    neXtProt AC: NX_Q9HBE4

  • Chr Location
    4q27; chr4:122612628-122621057 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IL21 associations

Human Disease Mouse Models
       Immunodeficiency, Common Variable, 11; CVID11   OMIM: 615767
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Radiation induced
    2
  • Targeted
    6
  • Transgenic
    2
  • Genomic Mutations
    2 involving Il21
  • Incidental Mutations
Mice homozygous for disruptions in this gene develop normally and have a normal life span. One allele exhibits enhanced IgE isotype switch and IgE production after antigen immunization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007350 VEGA Gene Model | MGI Sequence Detail 9878 C57BL/6J ±  kb
transcript OTTMUST00000089349 VEGA | MGI Sequence Detail 529 Not Applicable  
polypeptide OTTMUSP00000048827 VEGA | MGI Sequence Detail 162 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    3 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 2
References
more
  • Summaries
    All 102
    Gene Ontology 7
    Phenotypes 58
  • Earliest
    J:65629 Parrish-Novak J, et al., Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000 Nov 2;408(6808):57-63
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory