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Il21
Gene Detail
 Symbol
Name
ID
Il21
interleukin 21
MGI:1890474
Feature Type protein coding gene
Genetic Map
Chromosome 3
18.36 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:37222759-37232618 bp, - strand
From VEGA annotation of GRCm38

  9860 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11032  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin-21
Gene Tree: Il21

Human
homologs
Human Homolog IL21, interleukin 21
NCBI Gene ID 59067
neXtProt AC  NX_Q9HBE4
Human Synonyms  CVID11, IL-21, Za11
Human Chr (Location)  4q26-q27; chr4:122612628-122621057 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IL21
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene develop normally and have a normal life span. One allele exhibits enhanced IgE isotype switch and IgE production after antigen immunization.
 
Interactions
Il21 interacts with 330 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process B cell apoptotic process, cell maturation, ...
Component extracellular region, extracellular space
Function cytokine activity, cytokine receptor binding, ...
External Resources: FuncBase
Expression
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000007350 (Evidence)
Ensembl Gene ModelENSMUSG00000027718 (Evidence)
Entrez Gene60505 (Evidence)
UniGene157689
DFCITC1662815
DoTSDT.101165114
NIA Mouse Gene IndexU023955
Consensus CDS ProjectCCDS17317.1, CCDS71236.1
International Mouse Knockout Project StatusIl21
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007350 VEGA Gene Model | MGI Sequence Detail 9860 C57BL/6J ±  kb
transcript OTTMUST00000089349 VEGA | MGI Sequence Detail 529 Not Applicable 
polypeptide OTTMUSP00000048827 VEGA | MGI Sequence Detail 162 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR003443 Interleukin-15-like
Protein Ontology PR:000001382 interleukin-21
References (Earliest) J:65629 Parrish-Novak J, et al., Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000 Nov 2;408(6808):57-63
(Latest) J:210825 Clarkson BD, et al., T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice. J Exp Med. 2014 Apr 7;211(4):595-604
All references(100)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory