Il21
Gene Detail

Symbol Name ID

Il21 interleukin 21 MGI:1890474

Feature Type

protein coding gene

Genetic Map

Chromosome 3

18.36 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:37222759-37232618 bp, - strand From VEGA annotation of GRCm38   9860 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Il21 ± 2 cM)

Protein SuperFamily: interleukin-21
Gene Tree: Il21

Human ortholog

IL21 interleukin 21 NCBI Gene ID 59067
Human Synonyms: IL-21, Za11
Human Chr4:123533783-123542211 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene develop normally and have a normal life span. One allele exhibits enhanced IgE isotype switch and IgE production after antigen immunization.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	B cell apoptotic process, cell maturation, ...
Component	extracellular region, extracellular space
Function	cytokine activity, cytokine receptor binding, ...

External Resources: FuncBase

Expression

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(5)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000007350 (Evidence)
Ensembl Gene Model	ENSMUSG00000027718 (Evidence)
Entrez Gene	60505 (Evidence)
UniGene	157689
DFCI	TC1662815
DoTS	DT.101165114
NIA Mouse Gene Index	U023955
Consensus CDS Project	CCDS17317.1
International Mouse Knockout Project Status	Il21

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007350	VEGA Gene Model | MGI Sequence Detail	9860	C57BL/6J
transcript	OTTMUST00000089349	VEGA | MGI Sequence Detail	529	Not Applicable
polypeptide	OTTMUSP00000048827	VEGA | MGI Sequence Detail	162	Not Applicable

All sequences(25) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(29 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003443	Interleukin-15-like
Protein Ontology	PR:000001382	interleukin-21

References

(Earliest) J:65629 Parrish-Novak J, et al., Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000 Nov 2;408(6808):57-63
(Latest) J:192815 Gutierrez T, et al., IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn(-/-) mice. Eur J Immunol. 2013 Feb;43(2):382-93
All references(89)