Paxip1
Gene Detail

Symbol Name ID

Paxip1 PAX interacting (with transcription-activation domain) protein 1 MGI:1890430

Synonyms

D5Ertd149e, PTIP

Feature Type

protein coding gene

Genetic Map

Chromosome 5

13.23 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:27740667-27791339 bp, - strand From Ensembl annotation of GRCm38   50673 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Paxip1 ± 2 cM)

Gene Tree: Paxip1

Human ortholog

PAXIP1 PAX interacting (with transcription-activation domain) protein 1 NCBI Gene ID 22976
Human Synonyms: CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2
Human Chr7:154735400-154794682 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human PAXIP1 (1)

Alleles and phenotypes

All alleles(14) : Targeted(3) Gene trapped(9) Chemically induced(2)
 

Homozygous mutant mice are developmentally retarded and embyronic lethal by E9.5.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	adipose tissue development, chorion development, ...
Component	histone methyltransferase complex, nucleus
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (99)    Tissues (99)    Images (1)
Theiler Stages: 17, 22

Assay Type	Results
RNA in situ	99

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(8) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000002221 (Evidence)
Entrez Gene	55982 (Evidence)
DFCI	TC1575974, TC1637302, TC1643693
DoTS	DT.101384522, DT.110648801, DT.531115, DT.91371200, DT.94343547
NIA Mouse Gene Index	U026024, U359103
Consensus CDS Project	CCDS39039.1
International Mouse Knockout Project Status	Paxip1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000002221	Ensembl Gene Model | MGI Sequence Detail	50673	C57BL/6J
transcript	ENSMUST00000002291	Ensembl | MGI Sequence Detail	5052	Not Applicable
polypeptide	ENSMUSP00000002291	Ensembl | MGI Sequence Detail	1056	Not Applicable

All sequences(33) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(226 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001357	BRCT domain
Protein Ontology	PR:000012322	PAX-interacting protein 1

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:190993 Schwab KR, et al., Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes. Dev Biol. 2013 Jan 1;373(1):64-71
All references(54)

Other accession IDs

MGI:1098588