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Paxip1
Gene Detail
Symbol

Name
ID
Paxip1
PAX interacting (with transcription-activation domain) protein 1
MGI:1890430
Synonyms
D5Ertd149e, PTIP
Feature Type
protein coding gene
Genetic Map
Chromosome 5
13.23 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:27740667-27791339 bp, - strand
From Ensembl annotation of GRCm38

  50673 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HCOP human homology predictions: PAXIP1
Gene Tree: Paxip1
Human
homologs
PAXIP1, PAX interacting (with transcription-activation domain) protein 1
Orthology source: HGNC

IDs:
NCBI Gene ID: 22976
neXtProt AC: NX_Q6ZW49

Human Synonyms: CAGF28, CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2

Human Chr (Location): 7q36; chr7:154943687-155003178 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PAXIP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(2) Gene trapped(9) Radiation induced(4) Targeted(3)
Genomic Mutations involving Paxip1 (4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice are developmentally retarded and embyronic lethal by E9.5.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Paxip1 interacts with 282 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process adipose tissue development, cellular response to DNA damage stimulus, ...
Component histone methyltransferase complex, nucleus
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (99)    Tissues (99)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 99
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase paxip1 ; ZFIN paxip1    NEW 
Molecular
reagents
All nucleic(10) cDNA(8) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000002221 (Evidence)
Entrez Gene 55982 (Evidence)
DFCI TC1637302, TC1575974, TC1643693
DoTS DT.101384522, DT.110648801, DT.531115, DT.91371200, DT.94343547
NIA Mouse Gene Index U359103, U026024
Consensus CDS Project CCDS39039.1
International Mouse Phenotyping Consortium Status Paxip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002221 Ensembl Gene Model | MGI Sequence Detail 50673 C57BL/6J ±  kb
transcript ENSMUST00000002291 Ensembl | MGI Sequence Detail 5052 Not Applicable 
polypeptide ENSMUSP00000002291 Ensembl | MGI Sequence Detail 1056 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(250 from dbSNP Build 137)    SNPs within 2kb including multiple locations(252)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
Protein Ontology PR:000012322 PAX-interacting protein 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:219797 Ranghini EJ, et al., Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms. Dev Biol. 2015 Mar 15;399(2):296-305
All references(55)
Other
accession IDs
MGI:1098588

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory