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Igf2bp2
Gene Detail
Symbol

Name
ID
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
MGI:1890358
Synonyms
C330012H03Rik, IMP-2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:22059009-22163299 bp, - strand
From VEGA annotation of GRCm38

  104291 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4774  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Igf2bp2

Human
homologs
Human Homolog IGF2BP2, insulin-like growth factor 2 mRNA binding protein 2
NCBI Gene ID 10644
neXtProt AC  NX_Q9Y6M1
Human Synonyms  IMP2, IMP-2, VICKZ2
Human Chr (Location)  3q27.2; chr3:185643739-185825050 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IGF2BP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(78) : Gene trapped(74) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Igf2bp2 interacts with 316 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process mRNA transport, regulation of translation, ...
Component cytoplasm, cytoskeleton, ...
Function mRNA 3'-UTR binding, mRNA 5'-UTR binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (9)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 2
Northern blot 5
RT-PCR 2
cDNA source data(133)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(135) cDNA(133) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000025859 (Evidence)
Ensembl Gene ModelENSMUSG00000033581 (Evidence)
Entrez Gene319765 (Evidence)
UniGene489442
DFCITC1777028, TC1646630, TC1606484, TC1597206
DoTSDT.101177634, DT.101380948, DT.101380942, DT.101737824, DT.492410
NIA Mouse Gene IndexU036909
Consensus CDS ProjectCCDS49797.1
International Mouse Knockout Project StatusIgf2bp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025859 VEGA Gene Model | MGI Sequence Detail 104291 C57BL/6J ±  kb
transcript OTTMUST00000063721 VEGA | MGI Sequence Detail 3899 Not Applicable 
polypeptide OTTMUSP00000031555 VEGA | MGI Sequence Detail 592 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(348 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004087 K Homology domain
InterPro IPR004088 K Homology domain, type 1
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
Protein Ontology PR:000008944 insulin-like growth factor 2 mRNA-binding protein 2
References
(Earliest) J:52252 Nielsen J, et al., A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol. 1999 Feb;19(2):1262-70
(Latest) J:212395 Laggai S, et al., The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. J Lipid Res. 2014 Apr 22;55(6):1087-1097
All references(44)
Other
accession IDs
MGI:2442686

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory