Gene Expression Literature Summary

• Symbol: Igf2bp2
• Name: insulin-like growth factor 2 mRNA binding protein 2
• ID: MGI:1890358

17 matching records from 17 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E4	E8.5	E9.5	E10.5	E11.5	E12.5	E13.5	E14.5	E15.5	E16.5	E17.5	P
Immunohistochemistry (section)											1	1	1	2		1		2
In situ RNA (section)											1		1	2			1
Immunohistochemistry (whole mount)	1	1	1	1	1	1	1											2
In situ RNA (whole mount)										1
Northern blot								1	1	1	1	2	1	1			1	1
Western blot	2	1	1	1		1	1			1	1	3	1	1				4
RT-PCR	1	1				1			1			5	2	2	1			8
cDNA clones												1

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Igf2bp2  insulin-like growth factor 2 mRNA binding protein 2   (Synonyms: C330012H03Rik, IMP2, IMP-2)
Results	Reference
2*	J:91358 Brants JR, Ayoubi TA, Chada K, Marchal K, Van de Ven WJ, Petit MM, Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS Lett. 2004 Jul 2;569(1-3):277-83
4	J:305124 Czepukojc B, Abuhaliema A, Barghash A, Tierling S, Nass N, Simon Y, Korbel C, Cadenas C, van Hul N, Sachinidis A, Hengstler JG, Helms V, Laschke MW, Walter J, Haybaeck J, Leclercq I, Kiemer AK, Kessler SM, IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis. Front Med (Lausanne). 2019;6:179
6*	J:305415 Dai N, Rapley J, Angel M, Yanik MF, Blower MD, Avruch J, mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry. Genes Dev. 2011 Jun 1;25(11):1159-72
3*	J:271356 Dai N, Zhao L, Wrighting D, Kramer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J, IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Cell Metab. 2015 Apr 7;21(4):609-21
4*	J:235757 Degrauwe N, Schlumpf TB, Janiszewska M, Martin P, Cauderay A, Provero P, Riggi N, Suva ML, Paro R, Stamenkovic I, The RNA Binding Protein IMP2 Preserves Glioblastoma Stem Cells by Preventing let-7 Target Gene Silencing. Cell Rep. 2016 May 24;15(8):1634-47
3	J:214927 Fujii Y, Kishi Y, Gotoh Y, IMP2 regulates differentiation potentials of mouse neocortical neural precursor cells. Genes Cells. 2013 Feb;18(2):79-89
10*	J:100054 Hammer NA, Hansen TO, Byskov AG, Rajpert-De Meyts E, Grondahl ML, Bredkjaer HE, Wewer UM, Christiansen J, Nielsen FC, Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer. Reproduction. 2005 Aug;130(2):203-12
1	J:340777 Laddach A, Chng SH, Lasrado R, Progatzky F, Shapiro M, Erickson A, Sampedro Castaneda M, Artemov AV, Bon-Frauches AC, Amaniti EM, Kleinjung J, Boeing S, Ultanir S, Adameyko I, Pachnis V, A branching model of lineage differentiation underpinning the neurogenic potential of enteric glia. Nat Commun. 2023 Sep 22;14(1):5904
17*	J:302708 Liu HB, Muhammad T, Guo Y, Li MJ, Sha QQ, Zhang CX, Liu H, Zhao SG, Zhao H, Zhang H, Du YZ, Sun K, Liu K, Lu G, Guo XJ, Sha J, Fan HY, Gao F, Chen ZJ, RNA-Binding Protein IGF2BP2/IMP2 is a Critical Maternal Activator in Early Zygotic Genome Activation. Adv Sci (Weinh). 2019 Aug 7;6(15):1900295
2*	J:103446 McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA, A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005 Jul 20;5:14
9*	J:52252 Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC, A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development. Mol Cell Biol. 1999 Feb;19(2):1262-70
5	J:207231 Nishino J, Kim S, Zhu Y, Zhu H, Morrison SJ, A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife. 2013;2:e00924
1*	J:92177 Powles N, Babbs C, Ficker M, Schimmang T, Maconochie M, Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization. Dev Biol. 2004 Apr 1;268(1):24-38
1*	J:235719 Preitner N, Quan J, Li X, Nielsen FC, Flanagan JG, IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories. Development. 2016 Aug 1;143(15):2753-9
4*	J:280234 Regue L, Minichiello L, Avruch J, Dai N, Liver-specific deletion of IGF2 mRNA binding protein-2/IMP2 reduces hepatic fatty acid oxidation and increases hepatic triglyceride accumulation. J Biol Chem. 2019 Aug 2;294(31):11944-11951
1	J:302089 Vezzali R, Weise SC, Hellbach N, Machado V, Heidrich S, Vogel T, The FOXG1/FOXO/SMAD network balances proliferation and differentiation of cortical progenitors and activates Kcnh3 expression in mature neurons. Oncotarget. 2016 Jun 21;7(25):37436-37455
1	J:201463 Watson LA, Solomon LA, Li JR, Jiang Y, Edwards M, Shin-ya K, Beier F, Berube NG, Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63