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Robo2 Gene Detail
Summary
  • Symbol
    Robo2
  • Name
    roundabout guidance receptor 2
  • Synonyms
    2600013A04Rik, 9430089E08Rik, D230004I22Rik, mKIAA1568
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890110
    NCBI Gene: 268902
  • Gene Overview
    MyGene.info: ROBO2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:73892306-74411825 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      519520 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 42.17 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ROBO2, roundabout guidance receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ROBO2, roundabout guidance receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SAX3
  • Links
    NCBI Gene ID: 6092
    neXtProt AC: NX_Q9HCK4
    UniProt: Q9HCK4

  • Chr Location
    3p12.3; chr3:75906675-77649964 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 43188
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ROBO2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ROBO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 11 genetic backgrounds
    27 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants display postnatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and abnormal commissural axon growth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000017043 VEGA Gene Model | MGI Sequence Detail 519520 C57BL/6J ±  kb
    transcript OTTMUST00000041283 VEGA | MGI Sequence Detail 8124 Not Applicable  
    polypeptide OTTMUSP00000018523 VEGA | MGI Sequence Detail 1508 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      8951 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 86
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919376, MGI:2146680, MGI:2442690, MGI:2444910
    References
    more
    • Summaries
      All 170
      Developmental Gene Expression 111
      Gene Ontology 11
      Phenotypes 59
    • Earliest
      J:62188 Murtra P, et al., Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature. 2000 May 11;405(6783):180-3
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory