About   Help   FAQ
Robo2 Gene Detail
Summary
  • Symbol
    Robo2
  • Name
    roundabout guidance receptor 2
  • Synonyms
    2600013A04Rik, 9430089E08Rik, D230004I22Rik, mKIAA1568
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890110
    NCBI Gene: 268902
  • Alliance
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:73688727-74208713 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 42.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3121 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890110
protein coding gene Chr16:73688725-75244331 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022951
protein coding gene Chr16:73822305-74361500 (-)
A/J MGP_AJ_G0022919
protein coding gene Chr16:70604304-71114259 (-)
AKR/J MGP_AKRJ_G0022889
protein coding gene Chr16:72760133-73270615 (-)
BALB/cJ MGP_BALBcJ_G0022921
protein coding gene Chr16:70945735-71479356 (-)
C3H/HeJ MGP_C3HHeJ_G0022683
protein coding gene Chr16:73173803-73710162 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023369
protein coding gene Chr16:76223877-76766793 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020872
protein coding gene Chr16:69214626-69714131 (-)
CAST/EiJ MGP_CASTEiJ_G0022206
protein coding gene Chr16:73556498-74097761 (-)
CBA/J MGP_CBAJ_G0022653
protein coding gene Chr16:79419672-80012124 (-)
DBA/2J MGP_DBA2J_G0022786
protein coding gene Chr16:70434539-70948695 (-)
FVB/NJ MGP_FVBNJ_G0022761
protein coding gene Chr16:69821603-70337418 (-)
LP/J MGP_LPJ_G0022856
protein coding gene Chr16:73614753-74155839 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022779
protein coding gene Chr16:82222200-82905595 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023386
protein coding gene Chr16:73041447-73574891 (-)
PWK/PhJ MGP_PWKPhJ_G0021948
protein coding gene Chr16:70679464-71187892 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021778
protein coding gene Chr16:72684688-73201224 (-)
WSB/EiJ MGP_WSBEiJ_G0022253
protein coding gene Chr16:73212371-73757490 (-)



Homology
more
  • Human Ortholog
    ROBO2, roundabout guidance receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROBO2, roundabout guidance receptor 2
  • Synonyms
    SAX3
  • Links
    NCBI Gene ID: 6092
    neXtProt AC: NX_Q9HCK4
    UniProt: Q9HCK4

  • Chr Location
    3p12.3; chr3:75906675-77649964 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human ROBO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 12 genetic backgrounds
    27 phenotypes from multigenic genotypes
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display postnatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and abnormal commissural axon growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052516 Ensembl Gene Model | MGI Sequence Detail 519987 C57BL/6J ±  kb
    transcript ENSMUST00000226478 Ensembl | MGI Sequence Detail 8059 Not Applicable  
    polypeptide ENSMUSP00000154353 Ensembl | MGI Sequence Detail 1512 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      cDNA 90
      Primer pair 3
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919376, MGI:2146680, MGI:2442690, MGI:2444910
    References
    more
    • Summaries
      All 225
      Developmental Gene Expression 148
      Gene Ontology 11
      Phenotypes 88
    • Earliest
      J:62188 Murtra P, et al., Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature. 2000 May 11;405(6783):180-3
    • Latest
      J:342982 Waters BJ, et al., Islet architecture in adult mice is actively maintained by Robo2 expression in beta cells. Dev Biol. 2023 Nov 15;505:122-129

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory