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Robo2
Gene Detail
Symbol

Name
ID
Robo2
roundabout homolog 2 (Drosophila)
MGI:1890110
Synonyms
2600013A04Rik, 9430089E08Rik, D230004I22Rik, mKIAA1568
Feature Type
protein coding gene
Genetic Map
Chromosome 16
42.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:73892306-74411825 bp, - strand
From VEGA annotation of GRCm38

  519520 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:43188  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Robo2

Human
homologs
Human Homolog ROBO2, roundabout, axon guidance receptor, homolog 2 (Drosophila)
NCBI Gene ID 6092
neXtProt AC  NX_Q9HCK4
Human Synonyms  SAX3
Human Chr (Location)  3p12.3; chr3:75906694-77649964 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ROBO2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants display postnatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and abnormal commissural axon growth.
 
Interactions
Robo2 interacts with 437 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process axon guidance, axon midline choice point recognition, ...
Component axolemma, cell surface, ...
Function axon guidance receptor activity, identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (83 records)
Data Summary: Results (126)    Tissues (102)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 103
Northern blot 9
cDNA source data(78)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(87) cDNA(85) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017043 (Evidence)
Ensembl Gene ModelENSMUSG00000052516 (Evidence)
Entrez Gene268902 (Evidence)
UniGene171736
DFCITC1588749, TC1598207, TC1582550, TC1599235, TC1599587
DoTSDT.94169503, DT.91362377, DT.91326634, DT.91285545, DT.101741419
Consensus CDS ProjectCCDS49886.1
International Mouse Knockout Project StatusRobo2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017043 VEGA Gene Model | MGI Sequence Detail 519520 C57BL/6J ±  kb
transcript OTTMUST00000041283 VEGA | MGI Sequence Detail 8124 Not Applicable 
polypeptide OTTMUSP00000018523 VEGA | MGI Sequence Detail 1508 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(32) UniProt(11)
Polymorphisms
SNPs within 2kb(3175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000014152 roundabout homolog 2
References
(Earliest) J:62188 Murtra P, et al., Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature. 2000 May 11;405(6783):180-3
(Latest) J:210623 Yeh ML, et al., Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014 Apr 16;34(16):5717-31
All references(127)
Other
accession IDs
MGI:1919376, MGI:2146680, MGI:2442690, MGI:2444910

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory