Robo2
Gene Detail

Symbol Name ID

Robo2 roundabout homolog 2 (Drosophila) MGI:1890110

Synonyms

2600013A04Rik, 9430089E08Rik, D230004I22Rik, mKIAA1568

Feature Type

protein coding gene

Genetic Map

Chromosome 16

42.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:73892306-74411825 bp, - strand From VEGA annotation of GRCm38   519520 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:43188  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Robo2

Human homologs

Human Homolog		ROBO2, roundabout, axon guidance receptor, homolog 2 (Drosophila)
NCBI Gene ID		6092
neXtProt AC		NX_Q9HCK4
Human Synonyms		SAX3
Human Chr (Location)		3p12.3; chr3:75955845-77699115 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ROBO2

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Homozygous mutants display postnatal lethality, abnormal ureteric bud development, multiple fused kidneys, multiple ureters, and abnormal commissural axon growth.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	axon guidance, axon midline choice point recognition, ...
Component	axolemma, cell surface, ...
Function	axon guidance receptor activity, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (76 records)
Data Summary: Results (97)    Tissues (75)    Images (35)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	74
Northern blot	9

cDNA source data(78)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(85) cDNA(84) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000017043 (Evidence)
Ensembl Gene Model	ENSMUSG00000052516 (Evidence)
Entrez Gene	268902 (Evidence)
UniGene	171736
DFCI	TC1582550, TC1588749, TC1598207, TC1599235, TC1599587
DoTS	DT.101741419, DT.91285545, DT.91326634, DT.91362377, DT.94169503
Consensus CDS Project	CCDS49886.1
International Mouse Knockout Project Status	Robo2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017043	VEGA Gene Model | MGI Sequence Detail	519520	C57BL/6J
transcript	OTTMUST00000041283	VEGA | MGI Sequence Detail	8124	Not Applicable
polypeptide	OTTMUSP00000018523	VEGA | MGI Sequence Detail	1508	Not Applicable

All sequences(63) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(2615 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000014152	roundabout 2

References

(Earliest) J:62188 Murtra P, et al., Rewarding effects of opiates are absent in mice lacking the receptor for substance P. Nature. 2000 May 11;405(6783):180-3
(Latest) J:193400 Domyan ET, et al., Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013 Jan 14;24(1):52-63
All references(119)

Other accession IDs

MGI:1919376, MGI:2146680, MGI:2442690, MGI:2444910