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Foxo3 Gene Detail
Summary
  • Symbol
    Foxo3
  • Name
    forkhead box O3
  • Synonyms
    1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890081
    NCBI Gene: 56484
  • Gene Overview
    MyGene.info: FOXO3
Location & Maps
more
  • Sequence Map
    Chr10:42181841-42276755 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94915 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 22.79 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    FOXO3, forkhead box O3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FOXO3, forkhead box O3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
  • Links
    NCBI Gene ID: 2309
    neXtProt AC: NX_O43524

  • Chr Location
    6q21; chr6:108559823-108684769 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Foxo3 mouse models

Human Disease Mouse Models
       Teratoma, Ovarian   OMIM: 166950 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 7 alleles in 9 genetic backgrounds
    28 phenotypes from multigenic genotypes
    109 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    2 involving Foxo3
  • Incidental Mutations
Inactivation of the locus results in an ovarian defect involving follicular growth activation and leads progressively to female sterility. For some alleles defects in immune system function and hematopoiesis have also been reported.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020929 VEGA Gene Model | MGI Sequence Detail 94915 C57BL/6J ±  kb
transcript OTTMUST00000101194 VEGA | MGI Sequence Detail 2535 Not Applicable  
polypeptide OTTMUSP00000056660 VEGA | MGI Sequence Detail 672 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    728 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007641 forkhead box protein O3
  • InterPro Domains
    IPR001766 Fork head domain
    IPR030456 Fork head domain conserved site 2
    IPR032068 FOXO protein, KIX-binding domain
    IPR032067 FOXO protein, transactivation domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 21
    cDNA 18
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
less
MGI:1916006, MGI:1917519, MGI:2143914
References
more
  • Summaries
    All 226
    Developmental Gene Expression 42
    Diseases 3
    Gene Ontology 21
    Phenotypes 109
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:234727 Heller S, et al., Intestinal inflammation requires FOXO3 and prostaglandin E2-dependent lipogenesis and elevated lipid droplets. Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G844-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory