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Foxo3 Gene Detail
Summary
  • Symbol
    Foxo3
  • Name
    forkhead box O3
  • Synonyms
    1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890081
    NCBI Gene: 56484
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:42057841-42152691 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.79 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3011 from dbSNP Build 142
  • Strain Annotations
    27
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890081
 protein coding gene Chr10:42057837-42152751 (-)
129S1/SvImJ ENSMUSGG00200054753
 protein coding gene Chr10:38958205-38958552 (-)
129S1/SvImJ ENSMUSG00200008185
 protein coding gene Chr10:39008077-39036094 (-)
A/J ENSMUSGG00195055187
 protein coding gene Chr10:39235169-39235516 (-)
A/J ENSMUSG00195016596
 protein coding gene Chr10:39285051-39313168 (-)
AKR/J ENSMUSGG00220054675
 protein coding gene Chr10:38911633-38911980 (-)
AKR/J ENSMUSG00220025329
 protein coding gene Chr10:38961510-38989629 (-)
BALB/cJ ENSMUSG00180015752
 protein coding gene Chr10:39369224-39397335 (-)
BALB/cJ ENSMUSGG00180055396
 protein coding gene Chr10:39319345-39319692 (-)
C3H/HeJ ENSMUSG00175011814
 protein coding gene Chr10:39164343-39192461 (-)
C3H/HeJ ENSMUSGG00175054959
 protein coding gene Chr10:39114470-39114817 (-)
C57BL/6NJ ENSMUSG00215006100
 protein coding gene Chr10:38913690-38941807 (-)
C57BL/6NJ ENSMUSGG00215055472
 protein coding gene Chr10:38863809-38864156 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015277
 protein coding gene Chr10:37600701-37697166 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210025474
 protein coding gene Chr10:39057863-39085985 (-)
CBA/J ENSMUSGG00210054843
 protein coding gene Chr10:39007985-39008332 (-)
DBA/2J ENSMUSGG00185057363
 protein coding gene Chr10:39160569-39160916 (-)
DBA/2J ENSMUSG00185006483
 protein coding gene Chr10:39210448-39238563 (-)
FVB/NJ ENSMUSG00205012265
 protein coding gene Chr10:39125683-39153800 (-)
FVB/NJ ENSMUSGG00205054346
 protein coding gene Chr10:39075803-39076150 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055673
 protein coding gene Chr10:40948001-40948348 (-)
LP/J ENSMUSG00230005445
 protein coding gene Chr10:40997869-41025883 (-)
NOD/ShiLtJ ENSMUSGG00190054686
 protein coding gene Chr10:39288698-39289045 (-)
NOD/ShiLtJ ENSMUSG00190030590
 protein coding gene Chr10:39338573-39366687 (-)
NZO/HlLtJ ENSMUSGG00225055254
 protein coding gene Chr10:45253555-45253902 (-)
NZO/HlLtJ ENSMUSG00225017552
 protein coding gene Chr10:45303432-45331549 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010019648
 protein coding gene Chr10:40090196-40171988 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FOXO3, forkhead box O3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXO3, forkhead box O3
  • Synonyms
    AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
  • Links
    NCBI Gene ID: 2309
    UniProt: O43524

  • Chr Location
    6q21; chr6:108559652-108684774 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Foxo3 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    74 phenotypes from 7 alleles in 9 genetic backgrounds
    30 phenotypes from multigenic genotypes
    202 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of the locus results in an ovarian defect involving follicular growth activation and leads progressively to female sterility. For some alleles defects in immune system function and hematopoiesis have also been reported.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    148
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    988
  • Tissues
    243
  • cDNA Data
    21
  • Literature Summary
    70
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56484 NCBI Gene Model | MGI Sequence Detail 94851 C57BL/6J ±  kb
    transcript NM_001376967 RefSeq | MGI Sequence Detail 6787 ZRU/MplStud  
    polypeptide Q9WVH4 UniProt | EBI | MGI Sequence Detail 672 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 21
      Primer pair 9
      Other 3
      Antibodies 12

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916006, MGI:1917519, MGI:2143914
    References
    more
    • Summaries
      All 547
      Developmental Gene Expression 70
      Diseases 3
      Gene Ontology 34
      Phenotypes 202
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:388825 Gao J, et al., Maternal hyperhomocysteinemia compromises female offspring fertility through overactivation of primordial follicles. iScience. 2026 Jul 17;29(7):116393
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory