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Foxo3
Gene Detail
 Symbol
Name
ID
Foxo3
forkhead box O3
MGI:1890081
Synonyms 1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a
Feature Type protein coding gene
Genetic Map
Chromosome 10
22.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:42181841-42276755 bp, - strand
From VEGA annotation of GRCm38

  94915 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31039  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: forkhead box O protein
Gene Tree: Foxo3

Human
homologs
Human Homolog FOXO3, forkhead box O3
NCBI Gene ID 2309
neXtProt AC  NX_O43524
Human Synonyms  AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
Human Chr (Location)  6q21; chr6:108559823-108684769 (+)  GRCh38
Alleles
and
phenotypes
All alleles(31) : Chemically induced (ENU)(1) Gene trapped(25) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of the locus results in an ovarian defect involving follicular growth activation and leads progressively to female sterility. For some alleles defects in immune system function and hematopoiesis have also been reported.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process antral ovarian follicle growth, apoptotic process, ...
Component cytoplasm, cytosol, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (262)    Tissues (177)    Images (53)
Theiler Stages: 2, 3, 4, 5, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 243
Western blot 4
RT-PCR 15
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000020929 (Evidence)
Ensembl Gene ModelENSMUSG00000048756 (Evidence)
Entrez Gene56484 (Evidence)
DFCITC1583645, TC1611477
DoTSDT.101373964, DT.528156, DT.60100308, DT.91293293, DT.91327384
NIA Mouse Gene IndexU031728
Consensus CDS ProjectCCDS23810.1
International Mouse Knockout Project StatusFoxo3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020929 VEGA Gene Model | MGI Sequence Detail 94915 C57BL/6J ±  kb
transcript OTTMUST00000049477 VEGA | MGI Sequence Detail 6848 Not Applicable 
polypeptide OTTMUSP00000022929 VEGA | MGI Sequence Detail 672 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(728 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Transcription factor, fork head
InterPro IPR018122 Transcription factor, fork head, conserved site
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007641 forkhead box protein O3
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:208828 Bartell SM, et al., FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun. 2014;5:3773
All references(193)
Other
accession IDs
MGI:1916006, MGI:1917519, MGI:2143914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory