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Foxo3
Gene Detail
Symbol

Name
ID
Foxo3
forkhead box O3
MGI:1890081
Synonyms
1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a
Feature Type
protein coding gene
Genetic Map
Chromosome 10
22.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:42181841-42276755 bp, - strand
From VEGA annotation of GRCm38

  94915 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31039  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FOXO3
Protein SuperFamily: forkhead box O protein
Gene Tree: Foxo3

Human
homologs
FOXO3, forkhead box O3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2309
neXtProt AC: NX_O43524

Human Synonyms: AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A

Human Chr (Location): 6q21; chr6:108559823-108684769 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Chemically induced (ENU)(1) Gene trapped(13) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Inactivation of the locus results in an ovarian defect involving follicular growth activation and leads progressively to female sterility. For some alleles defects in immune system function and hematopoiesis have also been reported.
 
Human Diseases Modeled in Mice Using Foxo3 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Foxo3 interacts with 416 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process anatomical structure morphogenesis, antral ovarian follicle growth, ...
Component cytoplasm, cytosol, ...
Function chromatin DNA binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (255)    Tissues (172)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 243
Western blot 4
RT-PCR 8
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FOXO3 ZFIN foxo3a, foxo3b    NEW 
Molecular
reagents
All nucleic(21) cDNA(18) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000020929 (Evidence)
Ensembl Gene Model ENSMUSG00000048756 (Evidence)
Entrez Gene 56484 (Evidence)
DFCI TC1583645, TC1611477
DoTS DT.101373964, DT.528156, DT.60100308, DT.91293293, DT.91327384
NIA Mouse Gene Index U031728
Consensus CDS Project CCDS23810.1
International Mouse Phenotyping Consortium Status Foxo3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020929 VEGA Gene Model | MGI Sequence Detail 94915 C57BL/6J ±  kb
transcript OTTMUST00000049477 VEGA | MGI Sequence Detail 6848 Not Applicable 
polypeptide OTTMUSP00000022929 VEGA | MGI Sequence Detail 672 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(728 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001766 Fork head domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007641 forkhead box protein O3
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:222729 Milan G, et al., Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun. 2015;6:6670
All references(205)
Disease annotation references (1)
Other
accession IDs
MGI:1916006, MGI:1917519, MGI:2143914

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory