Foxo3
Gene Detail

Symbol Name ID

Foxo3 forkhead box O3 MGI:1890081

Synonyms

1110048B16Rik, 2010203A17Rik, Fkhr2, FKHRL1, Foxo3a

Feature Type

protein coding gene

Genetic Map

Chromosome 10

22.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:42181841-42276755 bp, - strand From VEGA annotation of GRCm38   94915 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31039  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: forkhead box O protein
Gene Tree: Foxo3

Human homologs

Human Homolog		FOXO3, forkhead box O3
NCBI Gene ID		2309
neXtProt AC		NX_O43524
Human Synonyms		AF6q21, FKHRL1, FKHRL1P2, FOXO2, FOXO3A
Human Chr (Location)		6q21; chr6:108881026-109005971 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(30) : Targeted(4) Gene trapped(25) Chemically induced(1)
 

Inactivation of the locus results in an ovarian defect involving follicular growth activation and leads progressively to female sterility. For some alleles defects in immune system function and hematopoiesis have also been reported.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (48 annotations)

Process	antral ovarian follicle growth, DNA damage response, signal transduction by p53 class mediator, ...
Component	cytoplasm, cytosol, ...
Function	DNA binding, DNA binding, bending, ...

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (262)    Tissues (177)    Images (53)
Theiler Stages: 2, 3, 4, 5, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	243
Western blot	4
RT-PCR	15

cDNA source data(17)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(17) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000020929 (Evidence)
Ensembl Gene Model	ENSMUSG00000048756 (Evidence)
Entrez Gene	56484 (Evidence)
DFCI	TC1583645, TC1611477
DoTS	DT.101373964, DT.528156, DT.60100308, DT.91293293, DT.91327384
NIA Mouse Gene Index	U031728
Consensus CDS Project	CCDS23810.1
International Mouse Knockout Project Status	Foxo3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020929	VEGA Gene Model | MGI Sequence Detail	94915	C57BL/6J
transcript	OTTMUST00000049477	VEGA | MGI Sequence Detail	6848	Not Applicable
polypeptide	OTTMUSP00000022929	VEGA | MGI Sequence Detail	672	Not Applicable

All sequences(53) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(658 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001766	Transcription factor, fork head
InterPro	IPR018122	Transcription factor, fork head, conserved site
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000007641	forkhead box protein O3

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:194535 Warr MR, et al., FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21;494(7437):323-7
All references(165)

Other accession IDs

MGI:1916006, MGI:1917519, MGI:2143914