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Elp2 Gene Detail
Summary
  • Symbol
    Elp2
  • Name
    elongator acetyltransferase complex subunit 2
  • Synonyms
    Stat3-interacting protein, Statip1, StIP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889642
    NCBI Gene: 58523
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:24737018-24771887 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 13.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889642
protein coding gene Chr18:24735923-24772564 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024203
protein coding gene Chr18:22374293-22410667 (+)
A/J MGP_AJ_G0024168
protein coding gene Chr18:21744644-21780611 (+)
AKR/J MGP_AKRJ_G0024137
protein coding gene Chr18:22385639-22421512 (+)
BALB/cJ MGP_BALBcJ_G0024168
protein coding gene Chr18:21808384-21845024 (+)
C3H/HeJ MGP_C3HHeJ_G0023936
protein coding gene Chr18:22329368-22365952 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024610
protein coding gene Chr18:23302638-23338810 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022052
protein coding gene Chr18:21588560-21622350 (+)
CAST/EiJ MGP_CASTEiJ_G0023410
protein coding gene Chr18:22116575-22152186 (+)
CBA/J MGP_CBAJ_G0023904
protein coding gene Chr18:23920608-23957488 (+)
DBA/2J MGP_DBA2J_G0024036
protein coding gene Chr18:21394065-21429215 (+)
FVB/NJ MGP_FVBNJ_G0024002
protein coding gene Chr18:21177922-21213331 (+)
LP/J MGP_LPJ_G0024117
protein coding gene Chr18:22526872-22561577 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024030
protein coding gene Chr18:24934267-24971485 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024658
protein coding gene Chr18:22161320-22198253 (+)
PWK/PhJ MGP_PWKPhJ_G0023154
protein coding gene Chr18:21539021-21575122 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022963
protein coding gene Chr18:22380665-22416862 (+)
WSB/EiJ MGP_WSBEiJ_G0023474
protein coding gene Chr18:22043836-22083031 (+)



Homology
more
  • Human Ortholog
    ELP2, elongator acetyltransferase complex subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELP2, elongator acetyltransferase complex subunit 2
  • Synonyms
    MRT58, SHINC-2, STATIP1, StIP
  • Links
    NCBI Gene ID: 55250
    neXtProt AC: NX_Q6IA86
    UniProt: Q6IA86

  • Chr Location
    18q12.2; chr18:36129444-36180557 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with Elp2 mouse models; 1 with human ELP2 associations

Human Disease Mouse Models
      
IDs
View 3 models
IDs
View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58523 NCBI Gene Model | MGI Sequence Detail 34870 C57BL/6J ±  kb
    transcript NM_021448 RefSeq | MGI Sequence Detail 2789 C57BL/6  
    polypeptide Q91WG4 UniProt | EBI | MGI Sequence Detail 831 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 169
      cDNA 169

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147318
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:306113 Kojic M, et al., Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nat Commun. 2021 May 11;12(1):2678

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory