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Sall1 Gene Detail
Summary
  • Symbol
    Sall1
  • Name
    spalt like transcription factor 1
  • Synonyms
    Msal-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889585
    NCBI Gene: 58198
  • Gene Overview
    MyGene.info: SALL1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:89027239-89044162 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 43.51 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889585
protein coding gene Chr8:89027235-89044162 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033924
protein coding gene Chr8:90148725-90165719 (-)
A/J MGP_AJ_G0033907
protein coding gene Chr8:86605080-86622105 (-)
AKR/J MGP_AKRJ_G0033833
protein coding gene Chr8:89131998-89148960 (-)
BALB/cJ MGP_BALBcJ_G0033900
protein coding gene Chr8:86757600-86774584 (-)
C3H/HeJ MGP_C3HHeJ_G0033610
protein coding gene Chr8:89752119-89769033 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034420
protein coding gene Chr8:93539038-93562080 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031362
protein coding gene Chr8:80561531-80578452 (-)
CAST/EiJ MGP_CASTEiJ_G0032941
protein coding gene Chr8:89204166-89221448 (-)
CBA/J MGP_CBAJ_G0033586
protein coding gene Chr8:96700897-96717870 (-)
DBA/2J MGP_DBA2J_G0033739
protein coding gene Chr8:86183951-86200967 (-)
FVB/NJ MGP_FVBNJ_G0033686
protein coding gene Chr8:85147447-85164996 (-)
LP/J MGP_LPJ_G0033831
protein coding gene Chr8:90265043-90283238 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033729
protein coding gene Chr8:99133660-99151964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034439
protein coding gene Chr8:89166492-89183951 (-)
PWK/PhJ MGP_PWKPhJ_G0032644
protein coding gene Chr8:85467162-85485763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032480
protein coding gene Chr8:87972058-87991360 (-)
WSB/EiJ MGP_WSBEiJ_G0033052
protein coding gene Chr8:89625178-89642768 (-)



Homology
more
  • Human Ortholog
    SALL1, spalt like transcription factor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SALL1, spalt like transcription factor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HEL-S-89, HSAL1, Sal-1, TBS, ZNF794
  • Links
    NCBI Gene ID: 6299
    neXtProt AC: NX_Q9NSC2
    UniProt: Q9NSC2

  • Chr Location
    16q12.1; chr16:51135975-51152386 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2230
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SALL1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Sall1 mouse models; 1 with human SALL1 associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 11 alleles in 10 genetic backgrounds
    19 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit kidney agenesis or dysgenesis and die perinatally. Homozygotes expressing only a truncated protein show renal agenesis, exencephaly, and limb defects; heterozygotes have hearing loss and cystic kidneys.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 58198 NCBI Gene Model | MGI Sequence Detail 16924 C57BL/6J ±  kb
    transcript NM_021390 RefSeq | MGI Sequence Detail 5275 C57BL/6  
    polypeptide Q9ER74 UniProt | EBI | MGI Sequence Detail 1322 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 3
      cDNA 53
      Primer pair 4
      Other 4

      Microarray probesets 4
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 70
      Diseases 2
      Gene Ontology 20
      Phenotypes 59
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory