Sall1tm1Mrau
Targeted Allele Detail
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Symbol: |
Sall1tm1Mrau |
Name: |
spalt like transcription factor 1; targeted mutation 1, Michael Rauchman |
MGI ID: |
MGI:2677452 |
Synonyms: |
sall1delta, Sall1-deltaZn, Sall1-deltaZn2-10 |
Gene: |
Sall1 Location: Chr8:89753867-89770790 bp, - strand Genetic Position: Chr8, 43.51 cM, cytoband D
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Alliance: |
Sall1tm1Mrau page
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Germline Transmission: |
Earliest citation of germline transmission:
J:85458
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Dominant negative) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A dominant-negative allele, recapitulating the human SALL1 1277-1278delGA mutation, was generated by inserting a stop codon and a floxed neo cassette into the exon 2. The deleted region corresponded with nt 1300-3443 of the cDNA. A truncated protein was detected by Western blot analyis of homozygous mutant embryonic tissue using an N-terminal antibody.
(J:85458)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sall1 Mutation: |
77 strains or lines available
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Original: |
J:85458 Kiefer SM, et al., Expression of a truncated Sall1 transcriptional repressor is responsible for Townes-Brocks syndrome birth defects. Hum Mol Genet. 2003 Sep 1;12(17):2221-7 |
All: |
5 reference(s) |
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