Tnfrsf13b
Gene Detail

Symbol Name ID

Tnfrsf13b tumor necrosis factor receptor superfamily, member 13b MGI:1889411

Synonyms

1200009E08Rik, Taci

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:61126755-61149372 bp, + strand From VEGA annotation of GRCm38   22618 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Tnfrsf13b

Human homologs

Human Homolog		TNFRSF13B, tumor necrosis factor receptor superfamily, member 13B
NCBI Gene ID		23495
neXtProt AC		NX_O14836
Human Synonyms		CD267, CVID, CVID2, TACI, TNFRSF14B
Human Chr (Location)		17p11.2; chr17:16842398-16875402 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human TNFRSF13B

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Nullizygous mice show increased B cell numbers and splenomegaly. Homozygotes for a null allele show impaired T cell-independent immune responses and isotype switching. Homozygotes for another null allele develop lymphoproliferation and fatal autoimmune nephritis with high titers of autoantibodies.

 
Human Diseases Modeled Using Mouse Tnfrsf13b (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Process	B cell homeostasis, negative regulation of B cell proliferation
Component	external side of plasma membrane, integral to membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(40) cDNA(40)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005824 (Evidence)
Ensembl Gene Model	ENSMUSG00000010142 (Evidence)
Entrez Gene	57916 (Evidence)
UniGene	265915
DFCI	TC1579719
DoTS	DT.101381051, DT.532303
NIA Mouse Gene Index	U012716
Consensus CDS Project	CCDS24806.1
International Mouse Knockout Project Status	Tnfrsf13b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005824	VEGA Gene Model | MGI Sequence Detail	22618	C57BL/6J
transcript	OTTMUST00000012921	VEGA | MGI Sequence Detail	2556	Not Applicable
polypeptide	OTTMUSP00000006011	VEGA | MGI Sequence Detail	249	Not Applicable

All sequences(43) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(73 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015384	TACI, cysteine-rich domain
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
InterPro	IPR022317	Tumour necrosis factor receptor 13B
Protein Ontology	PR:000001956	tumor necrosis factor receptor superfamily member 13B

References

(Earliest) J:63698 von Bulow GU, et al., Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse. Mamm Genome. 2000 Aug;11(8):628-32
(Latest) J:190155 Ou X, et al., Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival. Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):15401-6
All references(52)

Other accession IDs

MGI:1918966