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Tnfrsf13b Gene Detail
Summary
  • Symbol
    Tnfrsf13b
  • Name
    tumor necrosis factor receptor superfamily, member 13b
  • Synonyms
    1200009E08Rik, Taci
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889411
    NCBI Gene: 57916
  • Gene Overview
    MyGene.info: TNFRSF13B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:61126755-61149372 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22618 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TNFRSF13B, TNF receptor superfamily member 13B
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TNFRSF13B, TNF receptor superfamily member 13B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B
  • Links
    NCBI Gene ID: 23495
    neXtProt AC: NX_O14836
    UniProt: O14836

  • Chr Location
    17p11.2; chr17:16939084-16972088 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tnfrsf13b mouse models; 2 with human TNFRSF13B associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mice show increased B cell numbers and splenomegaly. Homozygotes for a null allele show impaired T cell-independent immune responses and isotype switching. Homozygotes for another null allele develop lymphoproliferation and fatal autoimmune nephritis with high titers of autoantibodies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005824 VEGA Gene Model | MGI Sequence Detail 22618 C57BL/6J ±  kb
    transcript OTTMUST00000012921 VEGA | MGI Sequence Detail 2556 Not Applicable  
    polypeptide OTTMUSP00000006011 VEGA | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      167 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918966
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 2
      Diseases 3
      Gene Ontology 7
      Phenotypes 45
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264035 Liu L, et al., TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis. Diabetes. 2018 Aug;67(8):1589-1603

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory