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Tnfrsf13b
Gene Detail
 Symbol
Name
ID
Tnfrsf13b
tumor necrosis factor receptor superfamily, member 13b
MGI:1889411
Synonyms 1200009E08Rik, Taci
Feature Type protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:61126755-61149372 bp, + strand
From VEGA annotation of GRCm38

  22618 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49320  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Tnfrsf13b

Human
homologs
Human Homolog TNFRSF13B, tumor necrosis factor receptor superfamily, member 13B
NCBI Gene ID 23495
neXtProt AC  NX_O14836
Human Synonyms  CD267, CVID, CVID2, RYZN, TACI, TNFRSF14B
Human Chr (Location)  17p11.2; chr17:16939084-16972088 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human TNFRSF13B
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Tnfrsf13b (2)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show increased B cell numbers and splenomegaly. Homozygotes for a null allele show impaired T cell-independent immune responses and isotype switching. Homozygotes for another null allele develop lymphoproliferation and fatal autoimmune nephritis with high titers of autoantibodies.
 
Human Diseases Modeled Using Mouse Tnfrsf13b (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Tnfrsf13b interacts with 260 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process B cell homeostasis, hematopoietic progenitor cell differentiation, ...
Component external side of plasma membrane, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(40)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005824 (Evidence)
Ensembl Gene ModelENSMUSG00000010142 (Evidence)
Entrez Gene57916 (Evidence)
UniGene265915
DFCITC1579719
DoTSDT.101381051, DT.532303
NIA Mouse Gene IndexU012716
Consensus CDS ProjectCCDS24806.1
International Mouse Knockout Project StatusTnfrsf13b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005824 VEGA Gene Model | MGI Sequence Detail 22618 C57BL/6J ±  kb
transcript OTTMUST00000012921 VEGA | MGI Sequence Detail 2556 Not Applicable 
polypeptide OTTMUSP00000006011 VEGA | MGI Sequence Detail 249 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(170 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015384 TACI, cysteine-rich domain
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022317 Tumour necrosis factor receptor 13B
Protein Ontology PR:000001956 tumor necrosis factor receptor superfamily member 13B
References (Earliest) J:63698 von Bulow GU, et al., Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse. Mamm Genome. 2000 Aug;11(8):628-32
(Latest) J:208355 Goenka R, et al., Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation. J Exp Med. 2014 Jan 13;211(1):45-56
All references(57)
Disease annotation references (1)
Other
accession IDs
MGI:1918966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory