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Tnfrsf13b Gene Detail
Summary
  • Symbol
    Tnfrsf13b
  • Name
    tumor necrosis factor receptor superfamily, member 13b
  • Synonyms
    1200009E08Rik, Taci
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889411
    NCBI Gene: 57916
  • Gene Overview
    MyGene.info: TNFRSF13B
Location & Maps
more
  • Sequence Map
    Chr11:61126755-61149372 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22618 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TNFRSF13B, TNF receptor superfamily member 13B
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TNFRSF13B, TNF receptor superfamily member 13B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD267, CVID, CVID2, IGAD2, RYZN, TACI, TNFRSF14B
  • Links
    NCBI Gene ID: 23495
    neXtProt AC: NX_O14836

  • Chr Location
    17p11.2; chr17:16939084-16972088 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tnfrsf13b mouse models; 2 with human TNFRSF13B associations

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 1 model
       Immunodeficiency, Common Variable, 2; CVID2   OMIM: 240500
Immunoglobulin A Deficiency 2; IGAD2   OMIM: 609529
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    3 involving Tnfrsf13b
  • Incidental Mutations
Nullizygous mice show increased B cell numbers and splenomegaly. Homozygotes for a null allele show impaired T cell-independent immune responses and isotype switching. Homozygotes for another null allele develop lymphoproliferation and fatal autoimmune nephritis with high titers of autoantibodies.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005824 VEGA Gene Model | MGI Sequence Detail 22618 C57BL/6J ±  kb
transcript OTTMUST00000012921 VEGA | MGI Sequence Detail 2556 Not Applicable  
polypeptide OTTMUSP00000006011 VEGA | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    167 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 40

    Microarray probesets 3
Other
Accession IDs
less
MGI:1918966
References
more
  • Summaries
    All 59
    Developmental Gene Expression 2
    Diseases 3
    Gene Ontology 6
    Phenotypes 42
  • Earliest
    J:63698 von Bulow GU, et al., Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse. Mamm Genome. 2000 Aug;11(8):628-32
  • Latest
    J:230609 Saulep-Easton D, et al., The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells. Leukemia. 2016 Jan;30(1):163-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory