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Cadm1
Gene Detail
Symbol

Name
ID
Cadm1
cell adhesion molecule 1
MGI:1889272
Synonyms
2900073G06Rik, 3100001I08Rik, Igsf4, Igsf4a, Necl2, RA175A, RA175B, RA175C, RA175N, SgIGSF, SynCam, Tslc1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
25.83 cM, cytoband B-C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr9:47530173-47857637 bp, + strand
From VEGA annotation of GRCm38

  327465 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Cadm1

Human
homologs
Human Homolog CADM1, cell adhesion molecule 1
NCBI Gene ID 23705
neXtProt AC  NX_Q9BY67
Human Synonyms  BL2, IGSF4, IGSF4A, Necl-2, NECL2, RA175, sgIGSF, ST17, sTSLC-1, SYNCAM, synCAM1, TSLC1
Human Chr (Location)  11q23.2; chr11:115173625-115504523 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(34) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant male show infertility due to block in maturation of spermatogenesis. Mice homozygous for a gene trap allele exhibit decreased body size, impaired T cell development, and impaired T cell response to anti-CD3/CD28 antibody stimulation.
 
Interactions
Cadm1 interacts with 406 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process apoptotic process, bone development, ...
Component axon, basolateral plasma membrane, ...
Function cell adhesion molecule binding, PDZ domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (281)    Tissues (81)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 281
cDNA source data(138)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(141) cDNA(141)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000024571 (Evidence)
Ensembl Gene ModelENSMUSG00000032076 (Evidence)
Entrez Gene54725 (Evidence)
UniGene234832
DFCITC1575657, TC1589970, TC1598744, TC1603229, TC1643284, TC1681052
DoTSDT.101160510, DT.101386875, DT.101735639, DT.526945, DT.94275161, DT.97369592, DT.97408498
NIA Mouse Gene IndexU010441
Consensus CDS ProjectCCDS23147.1, CCDS23148.1, CCDS23149.1, CCDS23150.1
International Mouse Knockout Project StatusCadm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024571 VEGA Gene Model | MGI Sequence Detail 327465 C57BL/6J ±  kb
transcript OTTMUST00000060347 VEGA | MGI Sequence Detail 1784 Not Applicable 
polypeptide OTTMUSP00000048779 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(12) UniProt(11)
Polymorphisms
SNPs within 2kb(2662 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR013106 Immunoglobulin V-set
InterPro IPR003585 Neurexin/syndecan/glycophorin C
Protein Ontology PR:000004960 cell adhesion molecule 1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:210552 Tattikota SG, et al., Argonaute2 mediates compensatory expansion of the pancreatic beta cell. Cell Metab. 2014 Jan 7;19(1):122-34
All references(97)
Other
accession IDs
MGI:1919652, MGI:1920304, MGI:2143168

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory