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Cadm1 Gene Detail
Summary
  • Symbol
    Cadm1
  • Name
    cell adhesion molecule 1
  • Synonyms
    2900073G06Rik, 3100001I08Rik, Igsf4, Igsf4a, Necl2, RA175A, RA175B, RA175C, RA175N, SgIGSF, SynCam, Tslc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889272
    NCBI Gene: 54725
  • Gene Overview
    MyGene.info: CADM1
Location & Maps
more
  • Sequence Map
    Chr9:47530173-47857637 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      327465 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 25.83 cM, cytoband B-C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CADM1, cell adhesion molecule 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CADM1, cell adhesion molecule 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BL2, IGSF4, IGSF4A, Necl-2, NECL2, RA175, sgIGSF, ST17, sTSLC-1, SYNCAM, synCAM1, TSLC1
  • Links
    NCBI Gene ID: 23705
    neXtProt AC: NX_Q9BY67

  • Chr Location
    11q23.2; chr11:115173625-115504523 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8641
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CADM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 7 alleles in 8 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant male show infertility due to block in maturation of spermatogenesis. Mice homozygous for a gene trap allele exhibit decreased body size, impaired T cell development, and impaired T cell response to anti-CD3/CD28 antibody stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024571 VEGA Gene Model | MGI Sequence Detail 327465 C57BL/6J ±  kb
transcript OTTMUST00000060347 VEGA | MGI Sequence Detail 1784 Not Applicable  
polypeptide OTTMUSP00000048779 VEGA | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2632 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 141
    cDNA 141

    Microarray probesets 8
Other
Accession IDs
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MGI:1919652, MGI:1920304, MGI:2143168
References
more
  • Summaries
    All 100
    Developmental Gene Expression 21
    Gene Ontology 12
    Phenotypes 29
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory