Angptl4
Gene Detail

Symbol Name ID

Angptl4 angiopoietin-like 4 MGI:1888999

Synonyms

BK89, FIAF, HFARP, NG27

Feature Type

protein coding gene

Genetic Map

Chromosome 17

17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:33773750-33781575 bp, - strand From VEGA annotation of GRCm38   7826 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Angptl4

Human homologs

Human Homolog		ANGPTL4, angiopoietin-like 4
NCBI Gene ID		51129
neXtProt AC		NX_Q9BY76
Human Synonyms		ANGPTL2, ARP4, FIAF, HFARP, NL2, PGAR, pp1158
Human Chr (Location)		19p13.3; chr19:8429011-8439257 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ANGPTL4

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(2)
 

Mice homozygous for disruptions in this gene display decreased levels of triglycerides and cholesterol and a lower increase in body fat after exposure to gut microbiota.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cellular response to starvation, negative regulation of apoptotic process, ...
Component	extracellular region, extracellular space, ...
Function	enzyme inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (177)    Tissues (31)    Images (48)
Theiler Stages: 9, 16, 21, 23, 26, 28

Assay Type	Results
RNA in situ	139
Northern blot	29
RT-PCR	9

cDNA source data(101)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(105) Genomic(1) cDNA(102) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000037206 (Evidence)
Ensembl Gene Model	ENSMUSG00000002289 (Evidence)
Entrez Gene	57875 (Evidence)
UniGene	196189
DFCI	TC1576537
DoTS	DT.535608
NIA Mouse Gene Index	U037690
Consensus CDS Project	CCDS28629.1
International Mouse Knockout Project Status	Angptl4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037206	VEGA Gene Model | MGI Sequence Detail	7826	C57BL/6J
transcript	OTTMUST00000095930	VEGA | MGI Sequence Detail	3053	Not Applicable
polypeptide	OTTMUSP00000053559	VEGA | MGI Sequence Detail	410	Not Applicable

All sequences(40) RefSeq(2) UniProt(4)

Polymorphisms

SNPs within 2kb(68 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002181	Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro	IPR014716	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro	IPR014715	Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro	IPR020837	Fibrinogen, conserved site
Protein Ontology	PR:000004029	angiopoietin-related protein 4

References

(Earliest) J:61082 Kim I, et al., Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochem J. 2000 Mar 15;346 Pt 3:603-10
(Latest) J:193800 Galaup A, et al., Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4. Circulation. 2012 Jan 3;125(1):140-9
All references(62)