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Angptl4
Gene Detail
Symbol

Name
ID
Angptl4
angiopoietin-like 4
MGI:1888999
Synonyms
BK89, FIAF, HFARP, NG27
Feature Type
protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:33773750-33781575 bp, - strand
From VEGA annotation of GRCm38

  7826 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ANGPTL4
Gene Tree: Angptl4

Human
homologs
ANGPTL4, angiopoietin-like 4
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51129
neXtProt AC: NX_Q9BY76

Human Synonyms: ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, pp1158, TGQTL, UNQ171

Human Chr (Location): 19p13.3; chr19:8364127-8374375 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display decreased levels of triglycerides and cholesterol and a lower increase in body fat after exposure to gut microbiota.
 
Phenotype Images(4)
Interactions
Angptl4 interacts with 182 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process angiogenesis, cellular response to starvation, ...
Component blood microparticle, extracellular region, ...
Function enzyme inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (177)    Tissues (31)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 139
Northern blot 29
RT-PCR 9
cDNA source data(102)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ANGPTL4 ; Xenbase angptl4 ; ZFIN angptl4    NEW 
Molecular
reagents
All nucleic(106) Genomic(1) cDNA(103) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000037206 (Evidence)
Ensembl Gene Model ENSMUSG00000002289 (Evidence)
Entrez Gene 57875 (Evidence)
UniGene 196189
DFCI TC1576537
DoTS DT.535608
NIA Mouse Gene Index U037690
Consensus CDS Project CCDS28629.1
International Mouse Phenotyping Consortium Status Angptl4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037206 VEGA Gene Model | MGI Sequence Detail 7826 C57BL/6J ±  kb
transcript OTTMUST00000095930 VEGA | MGI Sequence Detail 3053 Not Applicable 
polypeptide OTTMUSP00000053559 VEGA | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000004029 angiopoietin-related protein 4
References
(Earliest) J:61082 Kim I, et al., Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochem J. 2000 Mar 15;346 Pt 3:603-10
(Latest) J:220980 Vienberg SG, et al., Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity. Mol Metab. 2015 Feb;4(2):144-50
All references(70)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory