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Angptl4
Gene Detail
 Symbol
Name
ID
Angptl4
angiopoietin-like 4
MGI:1888999
Synonyms BK89, FIAF, HFARP, NG27
Feature Type protein coding gene
Genetic Map
Chromosome 17
17.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:33773750-33781575 bp, - strand
From VEGA annotation of GRCm38

  7826 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Angptl4

Human
homologs
Human Homolog ANGPTL4, angiopoietin-like 4
NCBI Gene ID 51129
neXtProt AC  NX_Q9BY76
Human Synonyms  ANGPTL2, ARP4, FIAF, HARP, HFARP, NL2, PGAR, pp1158, UNQ171
Human Chr (Location)  19p13.3; chr19:8364127-8374375 (+)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display decreased levels of triglycerides and cholesterol and a lower increase in body fat after exposure to gut microbiota.
 
Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process angiogenesis, cellular response to starvation, ...
Component blood microparticle, extracellular region, ...
Function enzyme inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (177)    Tissues (31)    Images (48)
Theiler Stages: 9, 16, 21, 23, 26, 28
Assay TypeResults
RNA in situ 139
Northern blot 29
RT-PCR 9
cDNA source data(102)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(106) Genomic(1) cDNA(103) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037206 (Evidence)
Ensembl Gene ModelENSMUSG00000002289 (Evidence)
Entrez Gene57875 (Evidence)
UniGene196189
DFCITC1576537
DoTSDT.535608
NIA Mouse Gene IndexU037690
Consensus CDS ProjectCCDS28629.1
International Mouse Knockout Project StatusAngptl4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037206 VEGA Gene Model | MGI Sequence Detail 7826 C57BL/6J ±  kb
transcript OTTMUST00000095930 VEGA | MGI Sequence Detail 3053 Not Applicable 
polypeptide OTTMUSP00000053559 VEGA | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(4)
Polymorphisms SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
InterPro IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
InterPro IPR014715 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
InterPro IPR020837 Fibrinogen, conserved site
Protein Ontology PR:000004029 angiopoietin-related protein 4
References (Earliest) J:61082 Kim I, et al., Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis. Biochem J. 2000 Mar 15;346 Pt 3:603-10
(Latest) J:200973 Xin X, et al., Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3425-34
All references(65)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory