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Cxcl13
Gene Detail
 Symbol
Name
ID
Cxcl13
chemokine (C-X-C motif) ligand 13
MGI:1888499
Synonyms 4631412M08Rik, ANGIE2, BCA-1, BLC, Scyb13
Feature Type protein coding gene
Genetic Map
Chromosome 5
47.29 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:95956939-95961068 bp, + strand
From NCBI annotation of GRCm38

  4130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48431  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: CXC chemokine
Gene Tree: Cxcl13

Human
homologs
Human Homolog CXCL13, chemokine (C-X-C motif) ligand 13
NCBI Gene ID 10563
neXtProt AC  NX_O43927
Human Synonyms  ANGIE, ANGIE2, BCA1, BCA-1, BLC, BLR1L, SCYB13
Human Chr (Location)  4q21; chr4:77511753-77611834 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
B lymphocyte trafficking is impaired in homozygous mutant mice.
 
Interactions
Cxcl13 interacts with 135 markers (Mir10a, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process activation of Rap GTPase activity, B cell chemotaxis, ...
Component cell, cytosol, ...
Function CCR10 chemokine receptor binding, chemokine activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (59)    Tissues (29)    Images (23)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 51
RT-PCR 8
cDNA source data(42)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) cDNA(42) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000023078 (Evidence)
Entrez Gene55985 (Evidence)
UniGene10116
DFCITC1579376
DoTSDT.492182, DT.97349147, DT.97372674
NIA Mouse Gene IndexU005820
Consensus CDS ProjectCCDS19447.1
International Mouse Knockout Project StatusCxcl13
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 55985 NCBI Gene Model | MGI Sequence Detail 4130 C57BL/6J ±  kb
transcript NM_018866 RefSeq | MGI Sequence Detail 1162 C57BL/6 
polypeptide O55038 UniProt | EBI | MGI Sequence Detail 109 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001811 Chemokine interleukin-8-like domain
InterPro IPR001089 CXC chemokine
InterPro IPR018048 CXC chemokine, conserved site
Protein Ontology PR:000006067 C-X-C motif chemokine 13
Graphical View of Protein Domain Structure
References (Earliest) J:45894 Gunn MD, et al., A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature. 1998 Feb 19;391(6669):799-803
(Latest) J:211677 Fleige H, et al., IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med. 2014 Apr 7;211(4):643-51
All references(77)
Other
accession IDs
MGI:1918033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory