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Cxcl13 Gene Detail
Summary
  • Symbol
    Cxcl13
  • Name
    chemokine (C-X-C motif) ligand 13
  • Synonyms
    4631412M08Rik, ANGIE2, BCA-1, BLC, Scyb13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888499
    NCBI Gene: 55985
  • Gene Overview
    MyGene.info: CXCL13
Location & Maps
more
  • Sequence Map
    Chr5:95956951-95961068 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4118 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CXCL13, C-X-C motif chemokine ligand 13
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CXCL13, C-X-C motif chemokine ligand 13
    Orthology source: HomoloGene
  • Synonyms
    ANGIE, ANGIE2, BCA1, BCA-1, BLC, BLR1L, SCYB13
  • Links
    NCBI Gene ID: 10563
    neXtProt AC: NX_O43927

  • Chr Location
    4q21; chr4:77511753-77611834 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    3 involving Cxcl13
  • Incidental Mutations
B lymphocyte trafficking is impaired in homozygous mutant mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055771 VEGA Gene Model | MGI Sequence Detail 4118 C57BL/6J ±  kb
transcript OTTMUST00000138021 VEGA | MGI Sequence Detail 1150 Not Applicable  
polypeptide OTTMUSP00000072614 VEGA | MGI Sequence Detail 109 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    50 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006067 C-X-C motif chemokine 13
  • InterPro Domains
    IPR001811 Chemokine interleukin-8-like domain
    IPR001089 CXC chemokine
    IPR018048 CXC chemokine, conserved site
Molecular
Reagents
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  • All nucleic 44
    cDNA 42
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1918033
References
more
  • Summaries
    All 77
    Developmental Gene Expression 13
    Gene Ontology 8
    Phenotypes 39
  • Earliest
    J:45894 Gunn MD, et al., A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature. 1998 Feb 19;391(6669):799-803
  • Latest
    J:217542 Obata Y, et al., Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues. EMBO Rep. 2014 Dec;15(12):1297-304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory