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Htr3b Gene Detail
Summary
  • Symbol
    Htr3b
  • Name
    5-hydroxytryptamine (serotonin) receptor 3B
  • Synonyms
    5-HT3B, 5-HT3 receptor subunit B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861899
    NCBI Gene: 57014
  • Gene Overview
    MyGene.info: HTR3B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:48935008-48964990 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29983 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 26.54 cM, cytoband B
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    HTR3B, 5-hydroxytryptamine receptor 3B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HTR3B, 5-hydroxytryptamine receptor 3B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    5-HT3B
  • Links
    NCBI Gene ID: 9177
    neXtProt AC: NX_O95264
    UniProt: O95264

  • Chr Location
    11q23.2; chr11:113904796-113949682 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57014 NCBI Gene Model | MGI Sequence Detail 29983 C57BL/6J ±  kb
    transcript NM_020274 RefSeq | MGI Sequence Detail 2411 C57BL/6  
    polypeptide Q9JHJ5 UniProt | EBI | MGI Sequence Detail 437 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      182 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008834 5-hydroxytryptamine receptor 3B
    • InterPro Domains
      IPR008132 5-hydroxytryptamine 3 receptor
      IPR008134 5-hydroxytryptamine 3 receptor, B subunit
      IPR006201 Neurotransmitter-gated ion-channel
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 4
      cDNA 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:62799 Hanna MC, et al., Evidence for expression of heteromeric serotonin 5-HT(3) receptors in rodents. J Neurochem. 2000 Jul;75(1):240-7
    • Latest
      J:263272 Bhattarai Y, et al., Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1;313(1):G80-G87

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory