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Aldh1a3
Gene Detail
Symbol

Name
ID
Aldh1a3
aldehyde dehydrogenase family 1, subfamily A3
MGI:1861722
Synonyms
ALDH6, RALDH3, retinaldehyde dehydrogenase 3, V1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
35.73 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:66390892-66427517 bp, - strand
From VEGA annotation of GRCm38

  36626 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ALDH1A3
Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh1a3

Human
homologs
ALDH1A3, aldehyde dehydrogenase 1 family, member A3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 220
neXtProt AC: NX_P47895

Human Synonyms: ALDH1A6, ALDH6, MCOP8, RALDH3

Human Chr (Location): 15q26.3; chr15:100879692-100916626 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ALDH1A3

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
Phenotype Images(1)
Interactions
Aldh1a3 interacts with 225 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (67 records)
Data Summary: Results (662)    Tissues (282)    Images (142)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 605
Northern blot 14
Western blot 5
RT-PCR 36
cDNA source data(60)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ALDH1A3 ; Xenbase aldh1a3 ; ZFIN aldh1a3    NEW 
Molecular
reagents
All nucleic(72) cDNA(63) Primer pair(5) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000036917 (Evidence)
Ensembl Gene Model ENSMUSG00000015134 (Evidence)
Entrez Gene 56847 (Evidence)
UniGene 140988
DFCI TC1577200, TC1592608, TC1694808
DoTS DT.40182605, DT.97335097
NIA Mouse Gene Index U028683
EC 1.2.1.5
Consensus CDS Project CCDS21345.1
International Mouse Phenotyping Consortium Status Aldh1a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036917 VEGA Gene Model | MGI Sequence Detail 36626 C57BL/6J ±  kb
transcript OTTMUST00000094854 VEGA | MGI Sequence Detail 3441 Not Applicable 
polypeptide OTTMUSP00000052868 VEGA | MGI Sequence Detail 512 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(586 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR016160 Aldehyde dehydrogenase, cysteine active site
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR029510 Aldehyde dehydrogenase, glutamic acid active site
InterPro IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
InterPro IPR016162 Aldehyde dehydrogenase N-terminal domain
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003922 aldehyde dehydrogenase family 1 member A3
References
(Earliest) J:63701 Li H, et al., A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse. Mech Dev. 2000 Jul;95(1-2):283-9
(Latest) J:220323 Carpenter AC, et al., Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse. Development. 2015 Mar 1;142(5):972-82
All references(107)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory