Aldh1a3
Gene Detail

Symbol Name ID

Aldh1a3 aldehyde dehydrogenase family 1, subfamily A3 MGI:1861722

Synonyms

ALDH6, RALDH3, retinaldehyde dehydrogenase 3, V1

Feature Type

protein coding gene

Genetic Map

Chromosome 7

35.73 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:66390892-66427517 bp, - strand From VEGA annotation of GRCm38   36626 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68080  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh1a3

Human homologs

Human Homolog		ALDH1A3, aldehyde dehydrogenase 1 family, member A3
NCBI Gene ID		220
neXtProt AC		NX_P47895
Human Synonyms		ALDH1A6, ALDH6, MCOP8, RALDH3
Human Chr (Location)		15q26.3; chr15:101420009-101456831 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for a null allele have a shorter ventral retina and severe nasal defects including choanal atresia which leads to lethal respiratory distress shortly after at birth. Homozygotes for another null allele lack a vitreous body and show neural retina thickening and a retrolenticular membrane.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	embryonic camera-type eye development, embryonic eye morphogenesis, ...
Component	cytoplasm
Function	3-chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (56 records)
Data Summary: Results (596)    Tissues (232)    Images (126)
Theiler Stages: 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	556
Northern blot	14
Western blot	5
RT-PCR	19

cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(68) cDNA(62) Primer pair(4) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000036917 (Evidence)
Ensembl Gene Model	ENSMUSG00000015134 (Evidence)
Entrez Gene	56847 (Evidence)
UniGene	140988
DFCI	TC1577200, TC1592608, TC1694808
DoTS	DT.40182605, DT.97335097
NIA Mouse Gene Index	U028683
EC	1.2.1.5
Consensus CDS Project	CCDS21345.1
International Mouse Knockout Project Status	Aldh1a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036917	VEGA Gene Model | MGI Sequence Detail	36626	C57BL/6J
transcript	OTTMUST00000094854	VEGA | MGI Sequence Detail	3441	Not Applicable
polypeptide	OTTMUSP00000052868	VEGA | MGI Sequence Detail	512	Not Applicable

All sequences(42) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(413 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016160	Aldehyde dehydrogenase, conserved site
InterPro	IPR016163	Aldehyde dehydrogenase, C-terminal
InterPro	IPR015590	Aldehyde dehydrogenase domain
InterPro	IPR016162	Aldehyde dehydrogenase, N-terminal
InterPro	IPR016161	Aldehyde/histidinol dehydrogenase
Protein Ontology	PR:000003922	aldehyde dehydrogenase family 1 member A3

References

(Earliest) J:63701 Li H, et al., A retinoic acid synthesizing enzyme in ventral retina and telencephalon of the embryonic mouse. Mech Dev. 2000 Jul;95(1-2):283-9
(Latest) J:193110 Griffin JN, et al., Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules. Dev Biol. 2013 Feb 1;374(1):185-97
All references(92)