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Actl6a Gene Detail
Summary
  • Symbol
    Actl6a
  • Name
    actin-like 6A
  • Synonyms
    2810432C06Rik, Actl6, ARP4, Baf53a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861453
    NCBI Gene: 56456
  • Gene Overview
    MyGene.info: ACTL6A
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:32708546-32726973 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 15.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861453
protein coding gene Chr3:32706298-32726973 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027141
protein coding gene Chr3:30329003-30350756 (+)
A/J MGP_AJ_G0027101
protein coding gene Chr3:29895577-29920493 (+)
AKR/J MGP_AKRJ_G0027070
protein coding gene Chr3:30367249-30387505 (+)
BALB/cJ MGP_BALBcJ_G0027113
protein coding gene Chr3:29548095-29568770 (+)
C3H/HeJ MGP_C3HHeJ_G0026856
protein coding gene Chr3:30384859-30405534 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027559
protein coding gene Chr3:31835574-31856352 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024920
protein coding gene Chr3:27714345-27734916 (+)
CAST/EiJ MGP_CASTEiJ_G0026309
protein coding gene Chr3:30250250-30271403 (+)
CBA/J MGP_CBAJ_G0026833
protein coding gene Chr3:32696686-32717361 (+)
DBA/2J MGP_DBA2J_G0026967
protein coding gene Chr3:29360054-29380342 (+)
FVB/NJ MGP_FVBNJ_G0026935
protein coding gene Chr3:28819946-28840240 (+)
LP/J MGP_LPJ_G0027079
protein coding gene Chr3:31096872-31117126 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026955
protein coding gene Chr3:35188259-35209824 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027618
protein coding gene Chr3:30148537-30168782 (+)
PWK/PhJ MGP_PWKPhJ_G0026042
protein coding gene Chr3:28901380-28922929 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025854
protein coding gene Chr3:29579433-29598779 (+)
WSB/EiJ MGP_WSBEiJ_G0026383
protein coding gene Chr3:30181160-30201938 (+)



Homology
more
  • Human Ortholog
    ACTL6A, actin like 6A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACTL6A, actin like 6A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACTL6, Arp4, ARPN-BETA, BAF53A, INO80K
  • Links
    NCBI Gene ID: 86
    neXtProt AC: NX_O96019
    UniProt: O96019

  • Chr Location
    3q26.33; chr3:179562880-179588405 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 55811
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACTL6A
  • Protein SuperFamily
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality before E6.5. Mice homozygous for a conditional allele activated in hematopoietic cells exhibit bone marrow failure and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56456 NCBI Gene Model | MGI Sequence Detail 18428 C57BL/6J ±  kb
    transcript NM_019673 RefSeq | MGI Sequence Detail 1969 C57BL/6  
    polypeptide Q9Z2N8 UniProt | EBI | MGI Sequence Detail 429 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919992, MGI:2139823, MGI:2140068
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 9
      Phenotypes 7
    • Earliest
      J:51248 Zhao K, et al., Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 1998 Nov 25;95(5):625-36
    • Latest
      J:238413 Saladi SV, et al., ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. Cancer Cell. 2017 Jan 09;31(1):35-49

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory