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Actl6a Gene Detail
Summary
  • Symbol
    Actl6a
  • Name
    actin-like 6A
  • Synonyms
    2810432C06Rik, Actl6, ARP4, Baf53a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861453
    NCBI Gene: 56456
  • Gene Overview
    MyGene.info: ACTL6A
Location & Maps
more
  • Sequence Map
    Chr3:32706298-32726973 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20676 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 15.83 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACTL6A, actin like 6A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACTL6A, actin like 6A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACTL6, Arp4, ARPN-BETA, BAF53A, INO80K
  • Links
    NCBI Gene ID: 86
    neXtProt AC: NX_O96019

  • Chr Location
    3q26.33; chr3:179562880-179588405 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 55811
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ACTL6A
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    61
  • Gene trapped
    56
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Actl6a
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic lethality before E6.5. Mice homozygous for a conditional allele activated in hematopoietic cells exhibit bone marrow failure and premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021872 VEGA Gene Model | MGI Sequence Detail 20676 C57BL/6J ±  kb
transcript OTTMUST00000051921 VEGA | MGI Sequence Detail 2010 Not Applicable  
polypeptide OTTMUSP00000024516 VEGA | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    163 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 6
Other
Accession IDs
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MGI:1919992, MGI:2139823, MGI:2140068
References
more
  • Summaries
    All 41
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:51248 Zhao K, et al., Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling. Cell. 1998 Nov 25;95(5):625-36
  • Latest
    J:212358 Singh AP, et al., Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014 Mar;42(5):2958-75

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory