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Gcm2
Gene Detail
Symbol

Name
ID
Gcm2
glial cells missing homolog 2 (Drosophila)
MGI:1861438
Synonyms
Gcm1-rs2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
20.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:41101427-41109988 bp, - strand
From Ensembl annotation of GRCm38

  8562 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GCM2
Gene Tree: Gcm2

Human
homologs
GCM2, glial cells missing homolog 2 (Drosophila)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9247
neXtProt AC: NX_O75603

Human Synonyms: GCMB, hGCMb

Human Chr (Location): 6p23; chr6:10872724-10886430 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GCM2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice lack parathyroid glands and exhibit hypocalcemia, hypophosphatemia, a mild abnormal bone phenotype, and partial perinatal lethality. Hypoparathyroidism is observed although parathyroid hormone serum levels are normal.
 
Human Diseases Modeled in Mice Using Gcm2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gcm2 interacts with 209 markers (Mir10b, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell differentiation, cellular calcium ion homeostasis, ...
Component cell, nucleus
Function DNA binding, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (206)    Tissues (186)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 173
RT-PCR 33
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GCM2 ZFIN gcm2    NEW 
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(14) Primer pair(6) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000021362 (Evidence)
Entrez Gene 107889 (Evidence)
UniGene 1399
DFCI TC1595019, TC1591306
DoTS DT.110969459, DT.40185384, DT.101143635
NIA Mouse Gene Index U034712
Consensus CDS Project CCDS26472.1
International Mouse Phenotyping Consortium Status Gcm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021362 Ensembl Gene Model | MGI Sequence Detail 8562 C57BL/6J ±  kb
transcript ENSMUST00000021791 Ensembl | MGI Sequence Detail 2879 Not Applicable 
polypeptide ENSMUSP00000021791 Ensembl | MGI Sequence Detail 504 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003902 Transcription regulator, GCM-like
Protein Ontology PR:000007900 chorion-specific transcription factor GCMb
References
(Earliest) J:35366 Altshuller Y, et al., Gcm1, a mammalian homolog of Drosophila glial cells missing. FEBS Lett. 1996 Sep 16;393(2-3):201-4
(Latest) J:217502 Chojnowski JL, et al., Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014 Oct;141(19):3697-708
All references(75)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37080, MGI:108044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory