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Gcm2 Gene Detail
Summary
  • Symbol
    Gcm2
  • Name
    glial cells missing homolog 2 (Drosophila)
  • Synonyms
    Gcm1-rs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861438
    NCBI Gene: 107889
  • Gene Overview
    MyGene.info: GCM2
Location & Maps
more
  • Sequence Map
    Chr13:41101427-41109988 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8562 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GCM2, glial cells missing homolog 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GCM2, glial cells missing homolog 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GCMB, hGCMb
  • Links
    NCBI Gene ID: 9247
    neXtProt AC: NX_O75603

  • Chr Location
    6p23; chr6:10872724-10886430 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3490
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GCM2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Gcm2 mouse models; 1 with human GCM2 associations

Human Disease Mouse Models
       Hypoparathyroidism, Familial Isolated; FIH   OMIM: 146200 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Gcm2
  • Incidental Mutations
Homozygous null mice lack parathyroid glands and exhibit hypocalcemia, hypophosphatemia, a mild abnormal bone phenotype, and partial perinatal lethality. Hypoparathyroidism is observed although parathyroid hormone serum levels are normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021362 Ensembl Gene Model | MGI Sequence Detail 8562 C57BL/6J ±  kb
transcript ENSMUST00000021791 Ensembl | MGI Sequence Detail 2879 Not Applicable  
polypeptide ENSMUSP00000021791 Ensembl | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    178 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR003902 Transcription regulator GCM domain
Molecular
Reagents
less
  • All nucleic 24
    Genomic 1
    cDNA 14
    Primer pair 6
    Other 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-37080, MGI:108044
References
more
  • Summaries
    All 72
    Developmental Gene Expression 37
    Diseases 1
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:35366 Altshuller Y, et al., Gcm1, a mammalian homolog of Drosophila glial cells missing. FEBS Lett. 1996 Sep 16;393(2-3):201-4
  • Latest
    J:217502 Chojnowski JL, et al., Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014 Oct;141(19):3697-708

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory