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Gcm2
Gene Detail
 Symbol
Name
ID
Gcm2
glial cells missing homolog 2 (Drosophila)
MGI:1861438
Synonyms Gcm1-rs2
Feature Type protein coding gene
Genetic Map
Chromosome 13
20.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:41101427-41109988 bp, - strand
From NCBI annotation of GRCm38

  8562 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Gcm2

Human
homologs
Human Homolog GCM2, glial cells missing homolog 2 (Drosophila)
NCBI Gene ID 9247
neXtProt AC  NX_O75603
Human Synonyms  GCMB, hGCMb
Human Chr (Location)  6p23; chr6:10873223-10881865 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GCM2
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice lack parathyroid glands and exhibit hypocalcemia, hypophosphatemia, a mild abnormal bone phenotype, and partial perinatal lethality. Hypoparathyroidism is observed although parathyroid hormone serum levels are normal.
 
Human Diseases Modeled Using Mouse Gcm2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gcm2 interacts with 209 markers (Mir10b, Mir17, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell differentiation, cellular calcium ion homeostasis, ...
Component cell, nucleus
Function DNA binding, metal ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (206)    Tissues (186)    Images (32)
Theiler Stages: 1, 2, 3, 4, 5, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 173
RT-PCR 33
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) Genomic(1) cDNA(14) Primer pair(6) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000021362 (Evidence)
Entrez Gene107889 (Evidence)
UniGene1399
DFCITC1591306, TC1595019
DoTSDT.101143635, DT.110969459, DT.40185384
NIA Mouse Gene IndexU034712
Consensus CDS ProjectCCDS26472.1
International Mouse Knockout Project StatusGcm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 107889 NCBI Gene Model | MGI Sequence Detail 8562 C57BL/6J ±  kb
transcript NM_008104 RefSeq | MGI Sequence Detail 2879 C57BL/6 
polypeptide O09102 UniProt | EBI | MGI Sequence Detail 504 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003902 Transcription regulator, GCM-like
Protein Ontology PR:000007900 chorion-specific transcription factor GCMb
Graphical View of Protein Domain Structure
References (Earliest) J:35366 Altshuller Y, et al., Gcm1, a mammalian homolog of Drosophila glial cells missing. FEBS Lett. 1996 Sep 16;393(2-3):201-4
(Latest) J:206528 David V, et al., Calcium regulates FGF-23 expression in bone. Endocrinology. 2013 Dec;154(12):4469-82
All references(73)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37080, MGI:108044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory