Gcm2
Gene Detail

Symbol Name ID

Gcm2 glial cells missing homolog 2 (Drosophila) MGI:1861438

Synonyms

Gcm1-rs2

Feature Type

protein coding gene

Genetic Map

Chromosome 13

20.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:41101427-41109988 bp, - strand From NCBI annotation of GRCm38   8562 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Gcm2

Human homologs

Human Homolog		GCM2, glial cells missing homolog 2 (Drosophila)
NCBI Gene ID		9247
neXtProt AC		NX_O75603
Human Synonyms		GCMB, hGCMb
Human Chr (Location)		6p23; chr6:10873456-10882098 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GCM2

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mice lack parathyroid glands and exhibit hypocalcemia, hypophosphatemia, a mild abnormal bone phenotype, and partial perinatal lethality. Hypoparathyroidism is observed although parathyroid hormone serum levels are normal.

 
Human Diseases Modeled Using Mouse Gcm2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cell differentiation, cellular calcium ion homeostasis, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (35 records)
Data Summary: Results (211)    Tissues (191)    Images (26)
Theiler Stages: 1, 2, 3, 4, 5, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	167
RT-PCR	44

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(1) cDNA(14) Primer pair(6) Other(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000021362 (Evidence)
Entrez Gene	107889 (Evidence)
UniGene	1399
DFCI	TC1591306, TC1595019
DoTS	DT.101143635, DT.110969459, DT.40185384
NIA Mouse Gene Index	U034712
Consensus CDS Project	CCDS26472.1
International Mouse Knockout Project Status	Gcm2

Sequences

Length	Strain/Species
genomic	107889	NCBI Gene Model | MGI Sequence Detail	8562	C57BL/6J
transcript	NM_008104	RefSeq | MGI Sequence Detail	2879	C57BL/6
polypeptide	O09102	UniProt | EBI | MGI Sequence Detail	504	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003902	Transcription regulator, GCM-like
Protein Ontology	PR:000007900	chorion-specific transcription factor GCMb

Graphical View of Protein Domain Structure

References

(Earliest) J:35366 Altshuller Y, et al., Gcm1, a mammalian homolog of Drosophila glial cells missing. FEBS Lett. 1996 Sep 16;393(2-3):201-4
(Latest) J:187709 Gardiner JR, et al., Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis. Development. 2012 Sep;139(18):3456-66
All references(72)

Other accession IDs

MGD-MRK-37080, MGI:108044