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Clec7a
Gene Detail
Symbol

Name
ID
Clec7a
C-type lectin domain family 7, member a
MGI:1861431
Synonyms
beta-glucan receptor, beta-GR, BGR, Clecsf12, dectin-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
63.34 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:129461591-129472777 bp, - strand
From VEGA annotation of GRCm38

  11187 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49606  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CLEC7A

Human
homologs
CLEC7A, C-type lectin domain family 7, member A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 64581
neXtProt AC: NX_Q9BXN2

Human Synonyms: BGR, CANDF4, CD369, CLECSF12, DECTIN1

Human Chr (Location): 12p13.2; chr12:10116777-10130273 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human CLEC7A

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this gene result in increased susceptibility and defective inflammatory responses in response to fungal infection.
 
Interactions
Clec7a interacts with 204 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (7)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000042656 (Evidence)
Ensembl Gene Model ENSMUSG00000102040 (Evidence), ENSMUSG00000079293 (Evidence)
Entrez Gene 56644 (Evidence)
UniGene 239516
DFCI TC1668093, TC1587603
DoTS DT.101158987, DT.489286, DT.94227975
NIA Mouse Gene Index U054047
PDB 2CL8, 2BPE, 2BPD, 2BPH
Consensus CDS Project CCDS71845.1
International Mouse Phenotyping Consortium Status Clec7a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042656 VEGA Gene Model | MGI Sequence Detail 11187 C57BL/6J ±  kb
transcript OTTMUST00000112324 VEGA | MGI Sequence Detail 2272 Not Applicable 
polypeptide OTTMUSP00000063059 VEGA | MGI Sequence Detail 244 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000001807 C-type lectin domain family 7 member A
References
(Earliest) J:62992 Ariizumi K, et al., Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem. 2000 Jun 30;275(26):20157-67
(Latest) J:218677 Jia XM, et al., CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. J Exp Med. 2014 Oct 20;211(11):2307-21
All references(101)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory