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Clec7a
Gene Detail
 Symbol
Name
ID
Clec7a
C-type lectin domain family 7, member a
MGI:1861431
BioType Conflict
Synonyms beta-glucan receptor, beta-GR, BGR, Clecsf12, dectin-1
Feature Type protein coding gene
Genetic Map
Chromosome 6
63.34 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:129463026-129472777 bp, - strand
From VEGA annotation of GRCm38

  9752 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:49606  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Clec7a

Human
homologs
Human Homolog CLEC7A, C-type lectin domain family 7, member A
NCBI Gene ID 64581
neXtProt AC  NX_Q9BXN2
Human Synonyms  BGR, CANDF4, CLECSF12, DECTIN1
Human Chr (Location)  12p13.2; chr12:10116777-10130269 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CLEC7A
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in increased susceptibility and defective inflammatory responses in response to fungal infection.
 
Interactions
Clec7a interacts with 205 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cell recognition, cell surface pattern recognition receptor signaling pathway, ...
Component external side of plasma membrane, integral component of membrane, ...
Function (1->3)-beta-D-glucan binding, (1->3)-beta-D-glucan receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (7)    Images (24)
Theiler Stages: 23
Assay TypeResults
RNA in situ 94
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000042656 (Evidence)
Ensembl Gene ModelENSMUSG00000079293 (Evidence)
Entrez Gene56644 (Evidence)
UniGene239516
DFCITC1587603, TC1668093
DoTSDT.101158987, DT.489286, DT.94227975
NIA Mouse Gene IndexU054047
PDB2BPD, 2BPE, 2BPH, 2CL8
Consensus CDS ProjectCCDS71845.1
International Mouse Knockout Project StatusClec7a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042656 VEGA Gene Model | MGI Sequence Detail 9752 C57BL/6J ±  kb
transcript OTTMUST00000112325 VEGA | MGI Sequence Detail 707 Not Applicable 
polypeptide OTTMUSP00000063060 VEGA | MGI Sequence Detail 199 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001304 C-type lectin
InterPro IPR016187 C-type lectin fold
InterPro IPR016186 C-type lectin-like
Protein Ontology PR:000001807 C-type lectin domain family 7 member A
References (Earliest) J:62992 Ariizumi K, et al., Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem. 2000 Jun 30;275(26):20157-67
(Latest) J:209412 Viriyakosol S, et al., Neither dectin-2 nor the mannose receptor is required for resistance to Coccidioides immitis in mice. Infect Immun. 2014 Mar;82(3):1147-56
All references(99)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory