Clec7a
Gene Detail

Symbol Name ID

Clec7a C-type lectin domain family 7, member a MGI:1861431

Synonyms

beta-glucan receptor, beta-GR, BGR, Clecsf12, dectin-1

Feature Type

protein coding gene

Genetic Map

Chromosome 6

63.34 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr6:129461591-129472777 bp, - strand From NCBI annotation of GRCm38   11187 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:49606  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Clec7a

Human homologs

Human Homolog		CLEC7A, C-type lectin domain family 7, member A
NCBI Gene ID		64581
neXtProt AC		NX_Q9BXN2
Human Synonyms		BGR, CANDF4, CLECSF12, DECTIN1
Human Chr (Location)		12p13.2; chr12:10269376-10282868 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CLEC7A

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mutations in this gene result in increased susceptibility and defective inflammatory responses in response to fungal infection.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	cell-cell adhesion, cell recognition, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	(1->3)-beta-D-glucan binding, (1->3)-beta-D-glucan receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (7)    Images (24)
Theiler Stages: 23

Assay Type	Results
RNA in situ	94

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(14)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000079293 (Evidence)
Entrez Gene	56644 (Evidence)
UniGene	239516
DFCI	TC1587603, TC1668093
DoTS	DT.101158987, DT.489286, DT.94227975
NIA Mouse Gene Index	U054047
PDB	2BPD, 2BPE, 2BPH, 2CL8
International Mouse Knockout Project Status	Clec7a

Sequences

Length	Strain/Species
genomic	56644	NCBI Gene Model | MGI Sequence Detail	11187	C57BL/6J
transcript	NM_020008	RefSeq | MGI Sequence Detail	2277	C57BL/6
polypeptide	Q6QLQ4	UniProt | EBI | MGI Sequence Detail	244	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(62 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001304	C-type lectin
InterPro	IPR016187	C-type lectin fold
InterPro	IPR016186	C-type lectin-like
Protein Ontology	PR:000001807	C-type lectin domain family 7 member A

Graphical View of Protein Domain Structure

References

(Earliest) J:62992 Ariizumi K, et al., Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem. 2000 Jun 30;275(26):20157-67
(Latest) J:192766 Karsten CM, et al., Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcgammaRIIB and dectin-1. Nat Med. 2012 Sep;18(9):1401-6
All references(85)