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Clec7a Pseudogene Detail
Summary
  • Symbol
    Clec7a
  • Name
    C-type lectin domain family 7, member a
  • Synonyms
    beta-glucan receptor, beta-GR, BGR, Clecsf12, dectin-1
  • Feature Type
    polymorphic pseudogene
  • IDs
    MGI:1861431
    NCBI Gene: 56644
  • Gene Overview
    MyGene.info: CLEC7A
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129461591-129472779 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.34 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861431
polymorphic pseudogene Chr6:129461591-129472779 (-)
129S1/SvImJ MGP_129S1SvImJ_G0009948
polymorphic pseudogene Chr6:133127323-133140433 (-)
A/J MGP_AJ_G0009933
polymorphic pseudogene Chr6:128035210-128047172 (-)
AKR/J MGP_AKRJ_G0009916
polymorphic pseudogene Chr6:131531722-131542945 (-)
BALB/cJ MGP_BALBcJ_G0009916
polymorphic pseudogene Chr6:127680008-127691305 (-)
C3H/HeJ MGP_C3HHeJ_G0009849
polymorphic pseudogene Chr6:131726564-131738430 (-)
C57BL/6NJ MGP_C57BL6NJ_G0010166
polymorphic pseudogene Chr6:136624133-136639650 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0008957
polymorphic pseudogene Chr6:126356647-126367998 (-)
CAST/EiJ MGP_CASTEiJ_G0009667
polymorphic pseudogene Chr6:131958881-131970429 (-)
CBA/J MGP_CBAJ_G0009823
polymorphic pseudogene Chr6:142002424-142017001 (-)
DBA/2J MGP_DBA2J_G0009850
polymorphic pseudogene Chr6:126985111-127003335 (-)
FVB/NJ MGP_FVBNJ_G0009869
polymorphic pseudogene Chr6:125872304-125883014 (-)
LP/J MGP_LPJ_G0009945
polymorphic pseudogene Chr6:133344781-133356483 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0009835
polymorphic pseudogene Chr6:145853072-145870872 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0010137
polymorphic pseudogene Chr6:131597595-131610580 (-)
PWK/PhJ MGP_PWKPhJ_G0009587
polymorphic pseudogene Chr6:125268860-125280362 (-)
SPRET/EiJ MGP_SPRETEiJ_G0009418
polymorphic pseudogene Chr6:129616318-129626755 (-)
WSB/EiJ MGP_WSBEiJ_G0009770
polymorphic pseudogene Chr6:132029183-132039804 (-)



Homology
more
  • Human Ortholog
    CLEC7A, C-type lectin domain containing 7A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CLEC7A, C-type lectin domain containing 7A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BGR, CANDF4, CD369, CLECSF12, DECTIN1, SCARE2
  • Links
    NCBI Gene ID: 64581
    neXtProt AC: NX_Q9BXN2
    UniProt: Q9BXN2

  • Chr Location
    12p13.2; chr12:10116777-10130269 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human CLEC7A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in increased susceptibility and defective inflammatory responses in response to fungal infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56644 NCBI Gene Model | MGI Sequence Detail 11189 C57BL/6J ±  kb
    transcript NR_132130 RefSeq | MGI Sequence Detail 2279 C57BL/6  
    polypeptide Q6QLQ4 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 2
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 79
    • Earliest
      J:62992 Ariizumi K, et al., Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning. J Biol Chem. 2000 Jun 30;275(26):20157-67
    • Latest
      J:261260 Gour N, et al., Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases. Sci Immunol. 2018 Feb 23;3(20)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory