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Clec4n Gene Detail
Summary
  • Symbol
    Clec4n
  • Name
    C-type lectin domain family 4, member n
  • Synonyms
    Clecsf10, dectin-2, Nkcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861231
    NCBI Gene: 56620
Location & Maps
more
  • Sequence Map
    Chr6:123229843-123247021 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17179 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 58.30 cM, cytoband F3
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CLEC6A, C-type lectin domain family 6 member A
  • Vertebrate Orthologs
    4
  • Human Ortholog
    CLEC6A, C-type lectin domain family 6 member A
    Orthology source: HomoloGene
  • Synonyms
    CLEC4N, CLECSF10
  • Links
    NCBI Gene ID: 93978
    neXtProt AC: NX_Q6EIG7

  • Chr Location
    chr12:8455995-8478330 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele have defective responses to Candida albicans.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027044 VEGA Gene Model | MGI Sequence Detail 17179 C57BL/6J ±  kb
transcript OTTMUST00000066844 VEGA | MGI Sequence Detail 1229 Not Applicable  
polypeptide OTTMUSP00000033554 VEGA | MGI Sequence Detail 209 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    131 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 9
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:1341853
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:55818 Fernandes MJ, et al., Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 1999 Jun 1;59(11):2709-17
  • Latest
    J:222104 Uryu H, et al., alpha-Mannan induces Th17-mediated pulmonary graft-versus-host disease in mice. Blood. 2015 May 7;125(19):3014-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory