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Arhgef7 Gene Detail
Summary
  • Symbol
    Arhgef7
  • Name
    Rho guanine nucleotide exchange factor (GEF7)
  • Synonyms
    betaPix, betaPix-b, betaPix-c, Cool, cool-1, p85SPR, Pak interacting exchange factor, PIX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860493
    NCBI Gene: 54126
  • Gene Overview
    MyGene.info: ARHGEF7
Location & Maps
more
  • Sequence Map
    Chr8:11727721-11835219 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      107499 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ARHGEF7, Rho guanine nucleotide exchange factor 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGEF7, Rho guanine nucleotide exchange factor 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BETA-PIX, COOL1, COOL-1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
  • Links
    NCBI Gene ID: 8874
    neXtProt AC: NX_Q14155

  • Chr Location
    13q34; chr13:111115277-111305734 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021108 VEGA Gene Model | MGI Sequence Detail 107499 C57BL/6J ±  kb
transcript OTTMUST00000049952 VEGA | MGI Sequence Detail 4926 Not Applicable  
polypeptide OTTMUSP00000023241 VEGA | MGI Sequence Detail 782 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    779 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004260 rho guanine nucleotide exchange factor 7
  • PDB
  • InterPro Domains
    IPR001715 Calponin homology domain
    IPR000219 Dbl homology (DH) domain
    IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
    IPR011993 PH domain-like
    IPR001849 Pleckstrin homology domain
    IPR032409 Rho guanine nucleotide exchange factor, coiled-coil domain
    IPR001452 SH3 domain
    IPR011511 Variant SH3 domain
Molecular
Reagents
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  • All nucleic 177
    cDNA 176
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 51
    Developmental Gene Expression 5
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:63104 Oh WK, et al., Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. Biochem Biophys Res Commun. 1997 Jun 27;235(3):794-8
  • Latest
    J:217373 Omelchenko T, et al., beta-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo. Genes Dev. 2014 Dec 15;28(24):2764-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory