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Arhgef7
Gene Detail
Symbol

Name
ID
Arhgef7
Rho guanine nucleotide exchange factor (GEF7)
MGI:1860493
Synonyms
betaPix, betaPix-b, betaPix-c, Cool, cool-1, p85SPR, Pak interacting exchange factor, PIX
Feature Type
protein coding gene
Genetic Map
Chromosome 8
5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:11728105-11835219 bp, + strand
From VEGA annotation of GRCm38

  107115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2895  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARHGEF7
Gene Tree: Arhgef7

Human
homologs
ARHGEF7, Rho guanine nucleotide exchange factor (GEF) 7
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8874
neXtProt AC: NX_Q14155

Human Synonyms: BETA-PIX, COOL1, COOL-1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB

Human Chr (Location): 13q34; chr13:111115277-111305734 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Arhgef7 interacts with 335 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process astrocyte cell migration, focal adhesion assembly, ...
Component cell junction, cell projection, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (45)    Tissues (44)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
Northern blot 6
RT-PCR 3
cDNA source data(175)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ARHGEF7 ; Xenbase arhgef7    NEW 
Molecular
reagents
All nucleic(177) cDNA(176) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021108 (Evidence)
Ensembl Gene Model ENSMUSG00000031511 (Evidence)
Entrez Gene 54126 (Evidence)
UniGene 244068
DFCI TC1595356, TC1605917, TC1591843, TC1575191, TC1583021, TC1608091
DoTS DT.91356050, DT.102556918, DT.101379648, DT.91303501, DT.91594448, DT.101379643, DT.101379644
NIA Mouse Gene Index U009080
PDB 2ESW
Consensus CDS Project CCDS22099.1, CCDS52480.1, CCDS52481.1
International Mouse Phenotyping Consortium Status Arhgef7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021108 VEGA Gene Model | MGI Sequence Detail 107115 C57BL/6J ±  kb
transcript OTTMUST00000049952 VEGA | MGI Sequence Detail 4926 Not Applicable 
polypeptide OTTMUSP00000023241 VEGA | MGI Sequence Detail 782 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(14) UniProt(2)
Polymorphisms
SNPs within 2kb(780 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000004260 rho guanine nucleotide exchange factor 7
References
(Earliest) J:63104 Oh WK, et al., Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. Biochem Biophys Res Commun. 1997 Jun 27;235(3):794-8
(Latest) J:217373 Omelchenko T, et al., beta-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo. Genes Dev. 2014 Dec 15;28(24):2764-77
All references(57)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory