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Arhgef7
Gene Detail
 Symbol
Name
ID
Arhgef7
Rho guanine nucleotide exchange factor (GEF7)
MGI:1860493
Synonyms betaPix, betaPix-b, betaPix-c, Cool, cool-1, p85SPR, Pak interacting exchange factor, PIX
Feature Type protein coding gene
Genetic Map
Chromosome 8
5.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:11728105-11835219 bp, + strand
From VEGA annotation of GRCm38

  107115 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2895  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Arhgef7

Human
homologs
Human Homolog ARHGEF7, Rho guanine nucleotide exchange factor (GEF) 7
NCBI Gene ID 8874
neXtProt AC  NX_Q14155
Human Synonyms  BETA-PIX, COOL1, COOL-1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
Human Chr (Location)  13q34; chr13:111115277-111305734 (+)  GRCh38
Alleles
and
phenotypes
All alleles(15) : Targeted(3) Gene trapped(12)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process hematopoietic progenitor cell differentiation, intracellular signal transduction, ...
Component cell junction, cell projection, ...
Function guanyl-nucleotide exchange factor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (45)    Tissues (43)    Images (11)
Theiler Stages: 19, 21, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 36
Northern blot 6
RT-PCR 3
cDNA source data(175)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(177) cDNA(176) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021108 (Evidence)
Ensembl Gene ModelENSMUSG00000031511 (Evidence)
Entrez Gene54126 (Evidence)
UniGene244068
DFCITC1575191, TC1583021, TC1591843, TC1595356, TC1605917, TC1608091
DoTSDT.101379643, DT.101379644, DT.101379648, DT.102556918, DT.91303501, DT.91356050, DT.91594448
NIA Mouse Gene IndexU009080
PDB2ESW
Consensus CDS ProjectCCDS22099.1, CCDS52480.1, CCDS52481.1
International Mouse Knockout Project StatusArhgef7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021108 VEGA Gene Model | MGI Sequence Detail 107115 C57BL/6J ±  kb
transcript OTTMUST00000049952 VEGA | MGI Sequence Detail 4926 Not Applicable 
polypeptide OTTMUSP00000023241 VEGA | MGI Sequence Detail 782 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(16) UniProt(2)
Polymorphisms SNPs within 2kb(780 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001715 Calponin homology domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000004260 rho guanine nucleotide exchange factor 7
References (Earliest) J:63104 Oh WK, et al., Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. Biochem Biophys Res Commun. 1997 Jun 27;235(3):794-8
(Latest) J:203427 Shibue T, et al., An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell. 2013 Oct 14;24(4):481-98
All references(54)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory