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Rabggta Gene Detail
Summary
  • Symbol
    Rabggta
  • Name
    Rab geranylgeranyl transferase, a subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860443
    NCBI Gene: 56187
Location & Maps
more
  • Sequence Map
    Chr14:55715873-55722257 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6385 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    RABGGTA, Rab geranylgeranyltransferase alpha subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RABGGTA, Rab geranylgeranyltransferase alpha subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTAR3
  • Links
    NCBI Gene ID: 5875
    neXtProt AC: NX_Q92696
    UniProt: Q92696

  • Chr Location
    14q12; chr14:24265538-24271627 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes exhibit diluted pigmentation, a platelet defect resulting in prolonged bleeding, macrothrombocytopenia, impaired killing by cytotoxic T lymphocytes, high mortality, and poor breeding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040472 Ensembl Gene Model | MGI Sequence Detail 6385 C57BL/6J ±  kb
transcript ENSMUST00000163889 Ensembl | MGI Sequence Detail 1880 Not Applicable  
polypeptide ENSMUSP00000128668 Ensembl | MGI Sequence Detail 567 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    43 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013653 geranylgeranyl transferase type-2 subunit alpha
  • EC
  • InterPro Domains
    IPR032955 Geranylgeranyl transferase type-2 subunit alpha
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR002088 Protein prenyltransferase, alpha subunit
    IPR009087 Rab geranylgeranyltransferase, alpha subunit, insert-domain
Molecular
Reagents
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  • All nucleic 56
    Genomic 6
    cDNA 50

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10168, MGI:95761
References
more
  • Summaries
    All 52
    Gene Ontology 4
    Phenotypes 26
  • Earliest
    J:13419 Dickie MM, Gunmetal. Mouse News Lett. 1964;30:30
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory