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Rabggta Gene Detail
Summary
  • Symbol
    Rabggta
  • Name
    Rab geranylgeranyl transferase, a subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860443
    NCBI Gene: 56187
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55715877-55722368 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860443
protein coding gene Chr14:55715416-55722368 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021365
protein coding gene Chr14:49758360-49764744 (-)
A/J MGP_AJ_G0021324
protein coding gene Chr14:48769693-48776076 (-)
AKR/J MGP_AKRJ_G0021300
protein coding gene Chr14:50520305-50526689 (-)
BALB/cJ MGP_BALBcJ_G0021328
protein coding gene Chr14:48735396-48741780 (-)
C3H/HeJ MGP_C3HHeJ_G0021108
protein coding gene Chr14:50201661-50208045 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021766
protein coding gene Chr14:52251749-52258133 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019313
protein coding gene Chr14:47138978-47145479 (-)
CAST/EiJ MGP_CASTEiJ_G0020627
protein coding gene Chr14:46465249-46471626 (-)
CBA/J MGP_CBAJ_G0021075
protein coding gene Chr14:53819283-53825667 (-)
DBA/2J MGP_DBA2J_G0021196
protein coding gene Chr14:48489014-48495398 (-)
FVB/NJ MGP_FVBNJ_G0021178
protein coding gene Chr14:47936717-47943072 (-)
LP/J MGP_LPJ_G0021270
protein coding gene Chr14:50806664-50813048 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021202
protein coding gene Chr14:53172880-53179264 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021793
protein coding gene Chr14:49701656-49708040 (-)
PWK/PhJ MGP_PWKPhJ_G0020374
protein coding gene Chr14:45022562-45029112 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020202
protein coding gene Chr14:45707156-45713576 (-)
WSB/EiJ MGP_WSBEiJ_G0020680
protein coding gene Chr14:49985971-49992355 (-)



Homology
more
  • Human Ortholog
    RABGGTA, Rab geranylgeranyltransferase subunit alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RABGGTA, Rab geranylgeranyltransferase subunit alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTAR3
  • Links
    NCBI Gene ID: 5875
    neXtProt AC: NX_Q92696
    UniProt: Q92696

  • Chr Location
    14q12; chr14:24265538-24271627 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Rabggta mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes exhibit diluted pigmentation, a platelet defect resulting in prolonged bleeding, macrothrombocytopenia, impaired killing by cytotoxic T lymphocytes, high mortality, and poor breeding.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56187 NCBI Gene Model | MGI Sequence Detail 6492 C57BL/6J ±  kb
transcript NR_153435 RefSeq | MGI Sequence Detail 2540 C57BL/6  
polypeptide Q9JHK4 UniProt | EBI | MGI Sequence Detail 567 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013653 geranylgeranyl transferase type-2 subunit alpha
  • EC
  • InterPro Domains
    IPR032955 Geranylgeranyl transferase type-2 subunit alpha
    IPR032675 Leucine-rich repeat domain superfamily
    IPR002088 Protein prenyltransferase, alpha subunit
    IPR009087 Rab geranylgeranyltransferase, alpha subunit, insert-domain
    IPR036254 Rab geranylgeranyltransferase, alpha subunit, insert-domain superfamily
Molecular
Reagents
less
  • All nucleic 57
    Genomic 6
    cDNA 51

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10168, MGI:95761
References
more
  • Summaries
    All 54
    Diseases 2
    Gene Ontology 6
    Phenotypes 25
  • Earliest
    J:12434 Swank RT, et al., Inherited abnormalities in platelet organelles and platelet formation and associated altered expression of low molecular weight guanosine triphosphate-binding proteins in the mouse pigment mutant gunmetal. Blood. 1993 May 15;81(10):2626-35
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory