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Spontaneous Allele Detail
Symbol: Rabggtagm
Name: Rab geranylgeranyl transferase, a subunit; gunmetal
MGI ID: MGI:1856886
Synonyms: gm
Gene: Rabggta  Location: Chr14:55953321-55959720 bp, - strand  Genetic Position: Chr14, 28.19 cM
Alliance: Rabggtagm page
C57BL/6J-Rabggtagm/Rabggtagm mice (Left) have a lighter coat color than coisogenic C57BL/6J-+/+ mice (Right).

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Allele Type:    Spontaneous
Mutation:    Single point mutation
Mutation detailsMice carrying the gunmetal mutation have a G-to-A substitution in the splice site acceptor site at the 3' end of intron 1. It eliminates the exon 2 splice acceptor by changing it from CAG to CAA, leading to mis-splicing. RT-PCR of extracts from gunmetal mice yielded two transcripts, a dominant 429 base pair transcript that lacks exon 1 and is predicted not to encode functional protein, and the 638 base pair, intron alpha retaining transcript found in wildtype mice. RABGGTA protein and enzymatic activity are found in gunmetal mice, but both are reduced by 70% relative to wildtype siblings. (J:52722)
Inheritance:    Recessive
A splice acceptor mutation in Rabggta causes abnormal splicing.
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rabggta Mutation:  12 strains or lines available
Original:  J:13419 Dickie MM, Gunmetal. Mouse News Lett. 1964;30:30
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory