Snx3 MGI Mouse Gene Detail - MGI:1860188

Symbol

Snx3
Name

sorting nexin 3
Synonyms

SDP3

Feature Type

protein coding gene
IDs

MGI:1860188
NCBI Gene: 54198
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr10:42378050-42411365 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 22.89 cM
Mapping Data

3 experiments

SNPs within 2kb

169 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1860188	protein coding gene	Chr10:42378026-42411377 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017185	protein coding gene	Chr10:41217096-41252798 (+)
A/J	MGP_AJ_G0017162	protein coding gene	Chr10:40058612-40092760 (+)
AKR/J	MGP_AKRJ_G0017122	protein coding gene	Chr10:40663551-40700803 (+)
BALB/cJ	MGP_BALBcJ_G0017124	protein coding gene	Chr10:40120954-40154892 (+)
C3H/HeJ	MGP_C3HHeJ_G0016945	protein coding gene	Chr10:41010180-41046264 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017583	protein coding gene	Chr10:42460109-42497283 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015279	protein coding gene	Chr10:37914391-37947042 (+)
CAST/EiJ	MGP_CASTEiJ_G0016524	protein coding gene	Chr10:41204411-41246180 (+)
CBA/J	MGP_CBAJ_G0016919	protein coding gene	Chr10:44404312-44459741 (+)
DBA/2J	MGP_DBA2J_G0017024	protein coding gene	Chr10:39540486-39574814 (+)
FVB/NJ	MGP_FVBNJ_G0017019	protein coding gene	Chr10:39035848-39069922 (+)
LP/J	MGP_LPJ_G0017101	protein coding gene	Chr10:41204804-41245449 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017049	protein coding gene	Chr10:45167878-45202798 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017620	protein coding gene	Chr10:40647256-40684011 (+)
PWK/PhJ	MGP_PWKPhJ_G0016304	protein coding gene	Chr10:39414400-39455766 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016088	protein coding gene	Chr10:40469036-40507856 (+)
WSB/EiJ	MGP_WSBEiJ_G0016587	protein coding gene	Chr10:40945865-40982149 (+)

Human Ortholog

SNX3, sorting nexin 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNX3, sorting nexin 3
Synonyms

Grd19, MCOPS8, SDP3
Links

HGNC:11174

NCBI Gene ID: 8724

neXtProt AC: NX_O60493

UniProt: O60493
Chr Location

6q21; chr6:108211222-108261246 (-) GRCh38

MGI Vertebrate Homology

Snx3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNX3
Gene Tree

Snx3

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Phenotype Summary

20 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

20
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Snx3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

47
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

954
Tissues

109
cDNA Data

225
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snx3

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All Sequences

51
RefSeq

2
UniProt

6
CCDS

CCDS23812.1

Ensembl

ENSMUSG00000019804 (Evidence)
NCBI Gene

54198

			Length	Strain/Species	Flank
genomic	54198	NCBI Gene Model \| MGI Sequence Detail	33316	C57BL/6J	± kb
transcript	NM_017472	RefSeq \| MGI Sequence Detail	1377	ZRU/MplStud
polypeptide	O70492	UniProt \| EBI \| MGI Sequence Detail	162	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015378 sorting nexin-3

(term hierarchy)
InterPro Domains

IPR001683 Phox homology

IPR036871 PX domain superfamily

IPR042137 Vertebrate SNX3, PX domain

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All nucleic 229

Genomic 1

cDNA 226

Primer pair 1

Other 1

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 5

Gene Ontology 5

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345344 Lu J, et al., Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3. Cell Death Differ. 2021 Oct;28(10):2871-2887

TSS for Snx3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93082	Chr10:42378032-42378037 (+)	-15 bp
Tssr93083	Chr10:42378044-42378051 (+)	-2 bp
Tssr93084	Chr10:42378056-42378079 (+)	18 bp
Tssr93085	Chr10:42378098-42378109 (+)	54 bp
Tssr93086	Chr10:42378121-42378132 (+)	77 bp
Tssr93087	Chr10:42378180-42378191 (+)	136 bp
Tssr93088	Chr10:42378193-42378278 (+)	186 bp
Tssr93089	Chr10:42409139-42409162 (+)	31,101 bp
Tssr93090	Chr10:42409198-42409212 (+)	31,155 bp
Tssr93091	Chr10:42410638-42410665 (+)	32,602 bp
Tssr93092	Chr10:42410805-42410824 (+)	32,765 bp
Tssr93093	Chr10:42410855-42410871 (+)	32,813 bp
Tssr93094	Chr10:42410900-42410923 (+)	32,862 bp
Tssr93095	Chr10:42410986-42411015 (+)	32,951 bp
Tssr93096	Chr10:42411038-42411049 (+)	32,994 bp
Tssr93097	Chr10:42411092-42411116 (+)	33,054 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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