Gabbr1 MGI Mouse Gene Detail - MGI:1860139 - gamma-aminobutyric acid (GABA) B receptor, 1

Gabbr1 Gene Detail

Symbol

Gabbr1
Name

gamma-aminobutyric acid (GABA) B receptor, 1
Synonyms

GABAB1, GABAbR1

Feature Type

protein coding gene
IDs

MGI:1860139
NCBI Gene: 54393
Gene Overview

MyGene.info: GABBR1

Sequence Map

Chr17:37045966-37075067 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

29102 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 19.16 cM
Mapping Data

5 experiments

Human Ortholog

GABBR1, gamma-aminobutyric acid type B receptor subunit 1

Vertebrate Orthologs

10

Human Ortholog

GABBR1, gamma-aminobutyric acid type B receptor subunit 1
Orthology source: HomoloGene, HGNC
Synonyms

GABABR1, GABBR1-3, GB1, GPRC3A
Links

HGNC:4070

NCBI Gene ID: 2550

neXtProt AC: NX_Q9UBS5

UniProt: Q9UBS5
Chr Location

6p22.1; chr6:29602228-29633135 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1132
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: GABBR1
Protein SuperFamily

gamma-aminobutyric acid B receptor
Gene Tree

Gabbr1

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Phenotype Summary

56 phenotypes from 8 alleles in 9 genetic backgrounds
54 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Gene trapped

27
Targeted

10
Genomic Mutations

1 involving Gabbr1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available

Phenotypes of null mice vary depending on strain background and allele. Homozygous null mice may display seizures, premature death, and abnormal nervous system electrophysiology.

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All GO Annotations

57
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

383
Tissues

159
cDNA Data

90
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gabbr1

ZFIN gabbr1a, gabbr1b

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Gabbr1 interacts with 330 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

59
RefSeq

5
UniProt

5
CCDS

CCDS37616.1
UniGene

32191

			Length	Strain/Species	Flank
genomic	OTTMUSG00000037319	VEGA Gene Model \| MGI Sequence Detail	29102	C57BL/6J	± kb
transcript	OTTMUST00000096317	VEGA \| MGI Sequence Detail	5248	Not Applicable
polypeptide	OTTMUSP00000053799	VEGA \| MGI Sequence Detail	960	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007761 gamma-aminobutyric acid type B receptor subunit 1

(term hierarchy)
InterPro Domains

IPR000337 GPCR, family 3

IPR017978 GPCR family 3, C-terminal

IPR002455 GPCR family 3, GABA-B receptor

IPR002456 GPCR family 3, gamma-aminobutyric acid receptor, type B1

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region

IPR000436 Sushi/SCR/CCP domain

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All nucleic 94

Genomic 1

cDNA 91

Primer pair 2

Microarray probesets 4

Summaries

All 99

Developmental Gene Expression 12

Gene Ontology 8

Phenotypes 54
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:234632 Zhang J, et al., Presynaptic Excitation via GABAB Receptors in Habenula Cholinergic Neurons Regulates Fear Memory Expression. Cell. 2016 Jul 28;166(3):716-28

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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