Gabbr1
Gene Detail

Symbol Name ID

Gabbr1 gamma-aminobutyric acid (GABA) B receptor, 1 MGI:1860139

Synonyms

GABAB1, GABAbR1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

19.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr17:37045966-37075067 bp, + strand From VEGA annotation of GRCm38   29102 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Gabbr1 ± 2 cM)

Protein SuperFamily: gamma-aminobutyric acid B receptor
Gene Tree: Gabbr1

Human ortholog

GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 NCBI Gene ID 2550
Human Synonyms: dJ271M21.1.1, dJ271M21.1.2, GABABR1, GABBR1-3, GB1, GPRC3A
Human Chr6:29570005-29600962 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(36) : Targeted(9) Gene trapped(27)
 

Phenotypes of null mice vary depending on strain background and allele. Homozygous null mice may display seizures, premature death, and abnormal nervous system electrophysiology.

 

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	gamma-aminobutyric acid signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	axolemma, cell junction, ...
Function	G-protein coupled GABA receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (383)    Tissues (157)    Images (127)
Theiler Stages: 19, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	202
In situ reporter (knock in)	134
RT-PCR	47

cDNA source data(90)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(94) Genomic(1) cDNA(91) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000037319 (Evidence)
Ensembl Gene Model	ENSMUSG00000024462 (Evidence)
Entrez Gene	54393 (Evidence)
UniGene	32191
DFCI	TC1575648, TC1602472, TC1641897
DoTS	DT.101128400, DT.101386951, DT.40168222, DT.60107145, DT.97338561, DT.97403273
NIA Mouse Gene Index	U017952
Consensus CDS Project	CCDS37616.1
International Mouse Knockout Project Status	Gabbr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037319	VEGA Gene Model | MGI Sequence Detail	29102	C57BL/6J
transcript	OTTMUST00000096317	VEGA | MGI Sequence Detail	5248	Not Applicable
polypeptide	OTTMUSP00000053799	VEGA | MGI Sequence Detail	960	Not Applicable

All sequences(66) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(118 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016060	Complement control module
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000337	GPCR, family 3
InterPro	IPR017978	GPCR, family 3, C-terminal
InterPro	IPR002455	GPCR, family 3, gamma-aminobutyric acid receptor, type B
InterPro	IPR002456	GPCR, family 3, gamma-aminobutyric acid receptor, type B1
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000007761	gamma-aminobutyric acid type B receptor subunit 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:191585 Takahata Y, et al., Positive regulation by gamma-aminobutyric acid B receptor subunit-1 of chondrogenesis through acceleration of nuclear translocation of activating transcription factor-4. J Biol Chem. 2012 Sep 28;287(40):33293-303
All references(87)