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Gabbr1
Gene Detail
Symbol

Name
ID
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
MGI:1860139
Synonyms
GABAB1, GABAbR1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
19.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:37045966-37075067 bp, + strand
From VEGA annotation of GRCm38

  29102 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1132  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GABBR1
Protein SuperFamily: gamma-aminobutyric acid B receptor
Gene Tree: Gabbr1

Human
homologs
GABBR1, gamma-aminobutyric acid (GABA) B receptor, 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2550
neXtProt AC: NX_Q9UBS5

Human Synonyms: dJ271M21.1.1, dJ271M21.1.2, GABABR1, GABBR1-3, GB1, GPRC3A

Human Chr (Location): 6p21.31; chr6:29602228-29633185 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(27) Targeted(10)
Genomic Mutations involving Gabbr1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Phenotypes of null mice vary depending on strain background and allele. Homozygous null mice may display seizures, premature death, and abnormal nervous system electrophysiology.
 
Phenotype Images(1)
Interactions
Gabbr1 interacts with 330 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Expression
Literature Summary: (12 records)
Data Summary: Results (383)    Tissues (159)    Images (127)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 202
In situ reporter (knock in) 134
RT-PCR 47
cDNA source data(90)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase gabbr1 ; ZFIN gabbr1a, gabbr1b    NEW 
Molecular
reagents
All nucleic(94) Genomic(1) cDNA(91) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000037319 (Evidence)
Ensembl Gene Model ENSMUSG00000024462 (Evidence)
Entrez Gene 54393 (Evidence)
UniGene 32191
DFCI TC1641897, TC1602472, TC1575648
DoTS DT.97338561, DT.97403273, DT.40168222, DT.101386951, DT.60107145, DT.101128400
NIA Mouse Gene Index U017952
Consensus CDS Project CCDS37616.1
International Mouse Phenotyping Consortium Status Gabbr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037319 VEGA Gene Model | MGI Sequence Detail 29102 C57BL/6J ±  kb
transcript OTTMUST00000096317 VEGA | MGI Sequence Detail 5248 Not Applicable 
polypeptide OTTMUSP00000053799 VEGA | MGI Sequence Detail 960 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(18) UniProt(5)
Polymorphisms
SNPs within 2kb(168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR002455 GPCR, family 3, gamma-aminobutyric acid receptor, type B
InterPro IPR002456 GPCR, family 3, gamma-aminobutyric acid receptor, type B1
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000007761 gamma-aminobutyric acid type B receptor subunit 1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:219628 Hanack C, et al., GABA blocks pathological but not acute TRPV1 pain signals. Cell. 2015 Feb 12;160(4):759-70
All references(95)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory