Gabbr1
Gene Detail

Symbol Name ID

Gabbr1 gamma-aminobutyric acid (GABA) B receptor, 1 MGI:1860139

Synonyms

GABAB1, GABAbR1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

19.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr17:37045966-37075067 bp, + strand From VEGA annotation of GRCm38   29102 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1132  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: gamma-aminobutyric acid B receptor
Gene Tree: Gabbr1

Human homologs

Human Homolog		GABBR1, gamma-aminobutyric acid (GABA) B receptor, 1
NCBI Gene ID		2550
neXtProt AC		NX_Q9UBS5
Human Synonyms		dJ271M21.1.1, dJ271M21.1.2, GABABR1, GABBR1-3, GB1, GPRC3A
Human Chr (Location)		6p21.31; chr6:29602228-29633185 (-)  GRCh38

Alleles and phenotypes

All alleles(36) : Gene trapped(27) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 

Phenotypes of null mice vary depending on strain background and allele. Homozygous null mice may display seizures, premature death, and abnormal nervous system electrophysiology.

 

Gene Ontology (GO) classifications

All GO classifications: (51 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, gamma-aminobutyric acid signaling pathway, ...
Component	axolemma, cell junction, ...
Function	G-protein coupled GABA receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)

Data Summary: Results (383)    Tissues (157)    Images (127)
Theiler Stages: 19, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	202
In situ reporter (knock in)	134
RT-PCR	47

cDNA source data(90)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(94) Genomic(1) cDNA(91) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000037319 (Evidence)
Ensembl Gene Model	ENSMUSG00000024462 (Evidence)
Entrez Gene	54393 (Evidence)
UniGene	32191
DFCI	TC1575648, TC1602472, TC1641897
DoTS	DT.101128400, DT.101386951, DT.40168222, DT.60107145, DT.97338561, DT.97403273
NIA Mouse Gene Index	U017952
Consensus CDS Project	CCDS37616.1
International Mouse Knockout Project Status	Gabbr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037319	VEGA Gene Model | MGI Sequence Detail	29102	C57BL/6J
transcript	OTTMUST00000096317	VEGA | MGI Sequence Detail	5248	Not Applicable
polypeptide	OTTMUSP00000053799	VEGA | MGI Sequence Detail	960	Not Applicable

All sequences(82) RefSeq(18) UniProt(5)

Polymorphisms

SNPs within 2kb(168 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000337	GPCR, family 3
InterPro	IPR017978	GPCR, family 3, C-terminal
InterPro	IPR002455	GPCR, family 3, gamma-aminobutyric acid receptor, type B
InterPro	IPR002456	GPCR, family 3, gamma-aminobutyric acid receptor, type B1
InterPro	IPR000436	Sushi/SCR/CCP
Protein Ontology	PR:000007761	gamma-aminobutyric acid type B receptor subunit 1

References

(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208808 Di Giorgio NP, et al., Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice. Endocrinology. 2014 Mar;155(3):1033-44
All references(95)