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Gabbr1
Gene Detail
 Symbol
Name
ID
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
MGI:1860139
Synonyms GABAB1, GABAbR1
Feature Type protein coding gene
Genetic Map
Chromosome 17
19.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr17:37045966-37075067 bp, + strand
From VEGA annotation of GRCm38

  29102 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1132  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: gamma-aminobutyric acid B receptor
Gene Tree: Gabbr1

Human
homologs
Human Homolog GABBR1, gamma-aminobutyric acid (GABA) B receptor, 1
NCBI Gene ID 2550
neXtProt AC  NX_Q9UBS5
Human Synonyms  dJ271M21.1.1, dJ271M21.1.2, GABABR1, GABBR1-3, GB1, GPRC3A
Human Chr (Location)  6p21.31; chr6:29602228-29633185 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(27) Targeted(10)
Genomic Mutations involving Gabbr1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Phenotypes of null mice vary depending on strain background and allele. Homozygous null mice may display seizures, premature death, and abnormal nervous system electrophysiology.
 
Interactions
Gabbr1 interacts with 331 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, gamma-aminobutyric acid signaling pathway, ...
Component axolemma, cell junction, ...
Function G-protein coupled GABA receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (383)    Tissues (159)    Images (127)
Theiler Stages: 19, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 202
In situ reporter (knock in) 134
RT-PCR 47
cDNA source data(90)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) Genomic(1) cDNA(91) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037319 (Evidence)
Ensembl Gene ModelENSMUSG00000024462 (Evidence)
Entrez Gene54393 (Evidence)
UniGene32191
DFCITC1575648, TC1602472, TC1641897
DoTSDT.101128400, DT.101386951, DT.40168222, DT.60107145, DT.97338561, DT.97403273
NIA Mouse Gene IndexU017952
Consensus CDS ProjectCCDS37616.1
International Mouse Knockout Project StatusGabbr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037319 VEGA Gene Model | MGI Sequence Detail 29102 C57BL/6J ±  kb
transcript OTTMUST00000096317 VEGA | MGI Sequence Detail 5248 Not Applicable 
polypeptide OTTMUSP00000053799 VEGA | MGI Sequence Detail 960 Not Applicable 

For the selected sequences
All sequences(82) RefSeq(18) UniProt(5)
Polymorphisms SNPs within 2kb(168 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR002455 GPCR, family 3, gamma-aminobutyric acid receptor, type B
InterPro IPR002456 GPCR, family 3, gamma-aminobutyric acid receptor, type B1
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000007761 gamma-aminobutyric acid type B receptor subunit 1
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:208808 Di Giorgio NP, et al., Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice. Endocrinology. 2014 Mar;155(3):1033-44
All references(95)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory