Cdc20
Gene Detail

Symbol Name ID

Cdc20 cell division cycle 20 MGI:1859866

Synonyms

2310042N09Rik, p55CDC

Feature Type

protein coding gene

Genetic Map

Chromosome 4

54.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:118432901-118437352 bp, - strand From VEGA annotation of GRCm38   4452 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37459  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cdc20

Human homologs

Human Homolog		CDC20, cell division cycle 20
NCBI Gene ID		991
neXtProt AC		NX_Q12834
Human Synonyms		bA276H19.3, CDC20A, p55CDC
Human Chr (Location)		1p34.1; chr1:43824626-43828874 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(7) Gene trapped(3)
 

Mice homozygous for mutations in this gene display embryonic lethality with cell cycle abnormalities. Mice heterozygous for a mutation in this gene display increased tumor incidence and increased incidence of aneuploidy.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	activation of anaphase-promoting complex activity, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, ...
Component	anaphase-promoting complex, centrosome, ...
Function	enzyme binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (110)    Tissues (21)    Images (21)
Theiler Stages: 1, 2, 3, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	62
Western blot	5
RT-PCR	43

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(13) Primer pair(4)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000008798 (Evidence)
Ensembl Gene Model	ENSMUSG00000006398 (Evidence)
Entrez Gene	107995 (Evidence)
NIA Mouse Gene Index	U025447, U089539, U373979
Consensus CDS Project	CCDS18551.1
International Mouse Knockout Project Status	Cdc20

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008798	VEGA Gene Model | MGI Sequence Detail	4452	C57BL/6J
transcript	OTTMUST00000020001	VEGA | MGI Sequence Detail	1793	Not Applicable
polypeptide	OTTMUSP00000009177	VEGA | MGI Sequence Detail	499	Not Applicable

All sequences(61) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000005188	cell division cycle protein 20

References

(Earliest) J:59059 Inbal N, et al., The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. FEBS Lett. 1999 Dec 17;463(3):350-4
(Latest) J:177486 Kim HS, et al., SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell. 2011 Oct 18;20(4):487-99
All references(60)

Other accession IDs

MGI:1913810, MGI:2146726