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Cdc20 Gene Detail
Summary
  • Symbol
    Cdc20
  • Name
    cell division cycle 20
  • Synonyms
    2310042N09Rik, p55CDC
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859866
    NCBI Gene: 107995
  • Gene Overview
    MyGene.info: CDC20
Location & Maps
more
  • Sequence Map
    Chr4:118432901-118437352 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4452 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 54.61 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CDC20, cell division cycle 20
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDC20, cell division cycle 20
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA276H19.3, CDC20A, p55CDC
  • Links
    NCBI Gene ID: 991
    neXtProt AC: NX_Q12834

  • Chr Location
    1p34.1; chr1:43358955-43363203 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37459
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: CDC20
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 6 alleles in 6 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    2
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    4 involving Cdc20
  • Incidental Mutations
Mice homozygous for mutations in this gene display embryonic lethality with cell cycle abnormalities. Mice heterozygous for a mutation in this gene display increased tumor incidence and increased incidence of aneuploidy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008798 VEGA Gene Model | MGI Sequence Detail 4452 C57BL/6J ±  kb
transcript OTTMUST00000020001 VEGA | MGI Sequence Detail 1793 Not Applicable  
polypeptide OTTMUSP00000009177 VEGA | MGI Sequence Detail 499 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000005188 cell division cycle protein 20
  • InterPro Domains
    IPR024977 Anaphase-promoting complex subunit 4, WD40 domain
    IPR033187 Cell division cycle protein 20 homologue
    IPR033010 The WD repeat Cdc20/Fizzy family
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 18
    cDNA 13
    Primer pair 5

    Microarray probesets 2
Other
Accession IDs
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MGI:1913810, MGI:2146726
References
more
  • Summaries
    All 65
    Developmental Gene Expression 18
    Gene Ontology 9
    Phenotypes 19
  • Earliest
    J:59059 Inbal N, et al., The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional and post-transcriptional levels. FEBS Lett. 1999 Dec 17;463(3):350-4
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory