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Crtam Gene Detail
Summary
  • Symbol
    Crtam
  • Name
    cytotoxic and regulatory T cell molecule
  • Synonyms
    class I-restricted T cell-associated molecule
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859822
    NCBI Gene: 54698
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:40972798-41004628 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 21.79 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    429 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859822
protein coding gene Chr9:40969691-41004628 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034673
protein coding gene Chr9:39225010-39256411 (-)
A/J MGP_AJ_G0034653
protein coding gene Chr9:38209129-38240568 (-)
AKR/J MGP_AKRJ_G0034579
protein coding gene Chr9:38929091-38960490 (-)
BALB/cJ MGP_BALBcJ_G0034644
protein coding gene Chr9:37950941-37982400 (-)
C3H/HeJ MGP_C3HHeJ_G0034355
protein coding gene Chr9:39454037-39485455 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035167
protein coding gene Chr9:40468066-40500373 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032080
protein coding gene Chr9:37834754-37866121 (-)
CAST/EiJ MGP_CASTEiJ_G0033678
protein coding gene Chr9:39183013-39215866 (-)
CBA/J MGP_CBAJ_G0034328
protein coding gene Chr9:41855994-41887383 (-)
DBA/2J MGP_DBA2J_G0034487
protein coding gene Chr9:38140877-38173085 (-)
FVB/NJ MGP_FVBNJ_G0034427
protein coding gene Chr9:37364858-37396490 (-)
LP/J MGP_LPJ_G0034568
protein coding gene Chr9:39496186-39527594 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034471
protein coding gene Chr9:43905295-43944866 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035186
protein coding gene Chr9:38852884-38884303 (-)
PWK/PhJ MGP_PWKPhJ_G0033383
protein coding gene Chr9:37953476-37985835 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033219
protein coding gene Chr9:39085834-39116943 (-)
WSB/EiJ MGP_WSBEiJ_G0033791
protein coding gene Chr9:38879364-38911811 (-)



Homology
more
  • Human Ortholog
    CRTAM, cytotoxic and regulatory T cell molecule
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CRTAM, cytotoxic and regulatory T cell molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD355
  • Links
    NCBI Gene ID: 56253
    neXtProt AC: NX_O95727
    UniProt: O95727

  • Chr Location
    11q24.1; chr11:122838419-122872643 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice have defects in late stage T cell activation that leads to less production of inflammatory cytokines, higher proliferation, and an increase in T cell number with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54698 NCBI Gene Model | MGI Sequence Detail 31831 C57BL/6J ±  kb
transcript NM_001281954 RefSeq | MGI Sequence Detail 1939 C57BL/6  
polypeptide Q149L7 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    Genomic 2
    cDNA 7
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:62065 Kennedy J, et al., A molecular analysis of NKT cells: identification of a class-I restricted T cell-associated molecule (CRTAM). J Leukoc Biol. 2000 May;67(5):725-34
  • Latest
    J:232587 Takeuchi A, et al., CRTAM determines the CD4+ cytotoxic T lymphocyte lineage. J Exp Med. 2016 Jan 11;213(1):123-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory