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Wdr45
Gene Detail
 Symbol
Name
ID
Wdr45
WD repeat domain 45
MGI:1859606
Synonyms C79260, DXImx38e, JM5, Sfc19, Wdrx1
Feature Type protein coding gene
Genetic Map
Chromosome X
3.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:7721973-7728201 bp, + strand
From VEGA annotation of GRCm38

  6229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48498  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Wdr45

Human
homologs
Human Homolog WDR45, WD repeat domain 45
NCBI Gene ID 11152
neXtProt AC  NX_Q9Y484
Human Synonyms  NBIA4, NBIA5, WDRX1, WIPI4, WIPI-4
Human Chr (Location)  Xp11.23; chrX:49074433-49101121 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human WDR45
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(30) Targeted(2)
Interactions
Wdr45 interacts with 116 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process autophagic vacuole assembly, autophagy, ...
Component cytosol, extrinsic component of membrane, ...
Function phosphatidylinositol-3,5-bisphosphate binding, phosphatidylinositol-3-phosphate binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (56)    Tissues (3)    Images (20)
Theiler Stages: 2, 3, 23
Assay TypeResults
RNA in situ 20
RT-PCR 36
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(66) Genomic(5) cDNA(60) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017803 (Evidence)
Ensembl Gene ModelENSMUSG00000039382 (Evidence)
Entrez Gene54636 (Evidence)
UniGene305725
DFCITC1579471, TC1593099
DoTSDT.101252399, DT.111024545, DT.493182, DT.94386805, DT.97382995
NIA Mouse Gene IndexU019664
Consensus CDS ProjectCCDS29970.1, CCDS72331.1
International Mouse Knockout Project StatusWdr45
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017803 VEGA Gene Model | MGI Sequence Detail 6229 C57BL/6J ±  kb
transcript OTTMUST00000043107 VEGA | MGI Sequence Detail 1299 Not Applicable 
polypeptide OTTMUSP00000019388 VEGA | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(105) RefSeq(20) UniProt(8)
Polymorphisms SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001180 Citron-like
InterPro IPR001680 WD40 repeat
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000032440 WD repeat domain phosphoinositide-interacting protein 4
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(36)
Other
accession IDs
MGI:2148058

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory