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Wdr45 Gene Detail
Summary
  • Symbol
    Wdr45
  • Name
    WD repeat domain 45
  • Synonyms
    C79260, DXImx38e, JM5, Sfc19, Wdrx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859606
    NCBI Gene: 54636
  • Gene Overview
    MyGene.info: WDR45
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7721983-7728201 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.48 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859606
protein coding gene ChrX:7714333-7728206 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035520
protein coding gene ChrX:2336805-2343034 (+)
A/J MGP_AJ_G0035498
protein coding gene ChrX:2299222-2305441 (+)
AKR/J MGP_AKRJ_G0035431
protein coding gene ChrX:2416506-2422667 (+)
BALB/cJ MGP_BALBcJ_G0035494
protein coding gene ChrX:2320813-2327042 (+)
C3H/HeJ MGP_C3HHeJ_G0035202
protein coding gene ChrX:2383058-2389286 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036018
protein coding gene ChrX:2418262-2424485 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032894
protein coding gene ChrX:1865699-1871798 (+)
CAST/EiJ MGP_CASTEiJ_G0034503
protein coding gene ChrX:2274568-2280780 (+)
CBA/J MGP_CBAJ_G0035172
protein coding gene ChrX:2543798-2550014 (+)
DBA/2J MGP_DBA2J_G0035329
protein coding gene ChrX:2325026-2331239 (+)
FVB/NJ MGP_FVBNJ_G0035276
protein coding gene ChrX:2281770-2287935 (+)
LP/J MGP_LPJ_G0035407
protein coding gene ChrX:2359224-2365451 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035316
protein coding gene ChrX:2496970-2503135 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036036
protein coding gene ChrX:2323590-2329809 (+)
PWK/PhJ MGP_PWKPhJ_G0034204
protein coding gene ChrX:2257464-2263686 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034042
protein coding gene ChrX:2289511-2295896 (+)
WSB/EiJ MGP_WSBEiJ_G0034626
protein coding gene ChrX:2330486-2336761 (+)



Homology
more
  • Human Ortholog
    WDR45, WD repeat domain 45
  • Vertebrate Orthologs
    8
  • Human Ortholog
    WDR45, WD repeat domain 45
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JM5, NBIA4, NBIA5, WDRX1, WIPI4, WIPI-4
  • Links
    NCBI Gene ID: 11152
    neXtProt AC: NX_Q9Y484
    UniProt: Q9Y484

  • Chr Location
    Xp11.23; chrX:49074433-49101121 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human WDR45 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 54636 NCBI Gene Model | MGI Sequence Detail 6219 C57BL/6J ±  kb
transcript NM_001290792 RefSeq | MGI Sequence Detail 1601 C57BL/6  
polypeptide Q91VM3 UniProt | EBI | MGI Sequence Detail 360 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    25 Sequences
  • Protein Ontology
    PR:000032440 WD repeat domain phosphoinositide-interacting protein 4
  • InterPro Domains
    IPR001180 Citron homology (CNH) domain
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    IPR032910 WD repeat domain phosphoinositide-interacting protein 4
Molecular
Reagents
less
  • All nucleic 68
    Genomic 5
    cDNA 62
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2148058
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory