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Acrbp Gene Detail
Summary
  • Symbol
    Acrbp
  • Name
    proacrosin binding protein
  • Synonyms
    OY-TES-1, sp32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859515
    NCBI Gene: 54137
Location & Maps
more
  • Sequence Map
    Chr6:125049689-125063267 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13579 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM, cytoband F2
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ACRBP, acrosin binding protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ACRBP, acrosin binding protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CT23, OY-TES-1, SP32
  • Links
    NCBI Gene ID: 84519
    neXtProt AC: NX_Q8NEB7

  • Chr Location
    12p13.31; chr12:6638076-6647414 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in delayed fertilization due to a delay in sperm penetration of the zona pellucida. Homozygous sperm also show reduced fertilization rates of oocytes with a thick or hardened zona pellucida.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024302 VEGA Gene Model | MGI Sequence Detail 13579 C57BL/6J ±  kb
transcript OTTMUST00000059516 VEGA | MGI Sequence Detail 1883 Not Applicable  
polypeptide OTTMUSP00000028949 VEGA | MGI Sequence Detail 540 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    40 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003653 acrosin-binding protein
  • InterPro Domains
    IPR009865 Proacrosin binding sp32
Molecular
Reagents
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  • All nucleic 40
    cDNA 39
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:71436 Baba T, et al., An acrosomal protein, sp32, in mammalian sperm is a binding protein specific for two proacrosins and an acrosin intermediate. J Biol Chem. 1994 Apr 1;269(13):10133-40
  • Latest
    J:202077 Kanemori Y, et al., Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse. Biol Reprod. 2013 Apr;88(4):105

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory