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Acrbp
Gene Detail
Symbol

Name
ID
Acrbp
proacrosin binding protein
MGI:1859515
Synonyms
OY-TES-1, sp32
Feature Type
protein coding gene
Genetic Map
Chromosome 6
59.17 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:125049689-125063267 bp, + strand
From VEGA annotation of GRCm38

  13579 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9641  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Acrbp

Human
homologs
Human Homolog ACRBP, acrosin binding protein
NCBI Gene ID 84519
neXtProt AC  NX_Q8NEB7
Human Synonyms  CT23, OY-TES-1, SP32
Human Chr (Location)  12p13.31; chr12:6638076-6647414 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in delayed fertilization due to a delay in sperm penetration of the zona pellucida. Homozygous sperm also show reduced fertilization rates of oocytes with a thick or hardened zona pellucida.
 
Interactions
Acrbp interacts with 35 markers (Mir27a, Mir139, Mir154, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process positive regulation of peptidase activity, spermatid development
Component acrosomal vesicle, cytoplasmic vesicle, ...
Function peptidase activator activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000024302 (Evidence)
Ensembl Gene ModelENSMUSG00000072770 (Evidence)
Entrez Gene54137 (Evidence)
UniGene347910
DFCITC1595817, TC1589348, TC1581568, TC1752148
DoTSDT.50315614, DT.101372502, DT.101372503
Consensus CDS ProjectCCDS20542.1, CCDS51910.1
International Mouse Knockout Project StatusAcrbp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024302 VEGA Gene Model | MGI Sequence Detail 13579 C57BL/6J ±  kb
transcript OTTMUST00000059516 VEGA | MGI Sequence Detail 1883 Not Applicable 
polypeptide OTTMUSP00000028949 VEGA | MGI Sequence Detail 540 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002350 Kazal domain
InterPro IPR009865 Proacrosin binding sp32
Protein Ontology PR:000003653 acrosin-binding protein
References
(Earliest) J:71436 Baba T, et al., An acrosomal protein, sp32, in mammalian sperm is a binding protein specific for two proacrosins and an acrosin intermediate. J Biol Chem. 1994 Apr 1;269(13):10133-40
(Latest) J:202077 Kanemori Y, et al., Two functional forms of ACRBP/sp32 are produced by pre-mRNA alternative splicing in the mouse. Biol Reprod. 2013 Apr;88(4):105
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory