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Acrbp Gene Detail
Summary
  • Symbol
    Acrbp
  • Name
    proacrosin binding protein
  • Synonyms
    OY-TES-1, sp32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859515
    NCBI Gene: 54137
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:125026890-125040228 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859515
protein coding gene Chr6:125026652-125040230 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031283
protein coding gene Chr6:128375170-128388727 (+)
A/J MGP_AJ_G0031253
protein coding gene Chr6:123532235-123546398 (+)
AKR/J MGP_AKRJ_G0031181
protein coding gene Chr6:126908306-126921952 (+)
BALB/cJ MGP_BALBcJ_G0031261
protein coding gene Chr6:123128940-123142515 (+)
C3H/HeJ MGP_C3HHeJ_G0030984
protein coding gene Chr6:126962538-126977605 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031717
protein coding gene Chr6:131753372-131766964 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028867
protein coding gene Chr6:120737035-120750928 (+)
CAST/EiJ MGP_CASTEiJ_G0030365
protein coding gene Chr6:127169637-127183493 (+)
CBA/J MGP_CBAJ_G0030945
protein coding gene Chr6:136796488-136818021 (+)
DBA/2J MGP_DBA2J_G0031101
protein coding gene Chr6:122463502-122477256 (+)
FVB/NJ MGP_FVBNJ_G0031051
protein coding gene Chr6:121369941-121384075 (+)
LP/J MGP_LPJ_G0031181
protein coding gene Chr6:128536885-128552202 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031089
protein coding gene Chr6:140844221-140858761 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031752
protein coding gene Chr6:126798885-126812492 (+)
PWK/PhJ MGP_PWKPhJ_G0030080
protein coding gene Chr6:120702997-120716819 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029909
protein coding gene Chr6:124881898-124897705 (+)
WSB/EiJ MGP_WSBEiJ_G0030450
protein coding gene Chr6:127167989-127182804 (+)



Homology
more
  • Human Ortholog
    ACRBP, acrosin binding protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACRBP, acrosin binding protein
  • Synonyms
    CT23, OY-TES-1, SP32
  • Links
    NCBI Gene ID: 84519
    neXtProt AC: NX_Q8NEB7
    UniProt: Q8NEB7

  • Chr Location
    12p13.31; chr12:6638075-6647433 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced male fertility associated with aberrant formation of the acrosomal granule, a fragmented acrosome structure, an abnormally condensed nuclear structure, and decreased sperm motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54137 NCBI Gene Model | MGI Sequence Detail 13339 C57BL/6J ±  kb
    transcript NM_016845 RefSeq | MGI Sequence Detail 1913 C57BL/6  
    polypeptide Q3V140 UniProt | EBI | MGI Sequence Detail 540 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 40
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:71436 Baba T, et al., An acrosomal protein, sp32, in mammalian sperm is a binding protein specific for two proacrosins and an acrosin intermediate. J Biol Chem. 1994 Apr 1;269(13):10133-40
    • Latest
      J:294381 Nagashima K, et al., Behavior of ACRBP-deficient mouse sperm in the female reproductive tract. J Reprod Dev. 2019 Apr 12;65(2):97-102

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory