Unc93b1
Gene Detail

Symbol Name ID

Unc93b1 unc-93 homolog B1 (C. elegans) MGI:1859307

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr19:3935186-3949340 bp, + strand From VEGA annotation of GRCm38   14155 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Unc93b1

Human homologs

Human Homolog		UNC93B1, unc-93 homolog B1 (C. elegans)
NCBI Gene ID		81622
neXtProt AC		NX_Q9H1C4
Human Synonyms		IIAE1, UNC93, UNC93B, Unc-93B1
Human Chr (Location)		11q13; chr11:67758575-67771593 (-)  GRCh37.p13
Disease Associations		(1) Diseases Associated with Human UNC93B1

Alleles and phenotypes

All alleles(4) : Targeted(3) Chemically induced(1)
 

Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	antigen processing and presentation of exogenous peptide antigen via MHC class II, defense response to virus, ...
Component	cell, cytoplasmic vesicle, ...
Function	protein binding, Toll-like receptor binding

External Resources: FuncBase

Expression

cDNA source data(62)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(62) cDNA(62)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000034969 (Evidence)
Ensembl Gene Model	ENSMUSG00000036908 (Evidence)
Entrez Gene	54445 (Evidence)
UniGene	262094
DFCI	TC1573365, TC1591147
DoTS	DT.101352186, DT.101395006, DT.101395010, DT.521709, DT.91334770, DT.94179588
NIA Mouse Gene Index	U038763
Consensus CDS Project	CCDS29404.2, CCDS50346.1
International Mouse Knockout Project Status	Unc93b1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034969	VEGA Gene Model | MGI Sequence Detail	14155	C57BL/6J
transcript	OTTMUST00000088920	VEGA | MGI Sequence Detail	2266	Not Applicable
polypeptide	OTTMUSP00000048530	VEGA | MGI Sequence Detail	619	Not Applicable

All sequences(44) RefSeq(6) UniProt(3)

Polymorphisms

SNPs within 2kb(71 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR010291	Ion channel regulatory protein, UNC-93
Protein Ontology	PR:000017102	protein unc-93 B1

References

(Earliest) J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
(Latest) J:204821 Clingan JM, et al., B Cell-intrinsic TLR7 signaling is required for optimal B cell responses during chronic viral infection. J Immunol. 2013 Jul 15;191(2):810-8
All references(61)