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Unc93b1
Gene Detail
Symbol

Name
ID
Unc93b1
unc-93 homolog B1 (C. elegans)
MGI:1859307
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:3935186-3949340 bp, + strand
From VEGA annotation of GRCm38

  14155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UNC93B1
Gene Tree: Unc93b1

Human
homologs
UNC93B1, unc-93 homolog B1 (C. elegans)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81622
neXtProt AC: NX_Q9H1C4

Human Synonyms: IIAE1, UNC93, UNC93B, Unc-93B1

Human Chr (Location): 11q13; chr11:67991100-68004125 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human UNC93B1

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired.
 
Interactions
Unc93b1 interacts with 103 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(62)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase unc93b1 ; ZFIN unc93b1    NEW 
Molecular
reagents
All nucleic(62) cDNA(62)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000034969 (Evidence)
Ensembl Gene Model ENSMUSG00000036908 (Evidence)
Entrez Gene 54445 (Evidence)
UniGene 262094
DFCI TC1573365, TC1591147
DoTS DT.101352186, DT.101395006, DT.101395010, DT.521709, DT.91334770, DT.94179588
NIA Mouse Gene Index U038763
Consensus CDS Project CCDS29404.2, CCDS50346.1
International Mouse Phenotyping Consortium Status Unc93b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034969 VEGA Gene Model | MGI Sequence Detail 14155 C57BL/6J ±  kb
transcript OTTMUST00000088920 VEGA | MGI Sequence Detail 2266 Not Applicable 
polypeptide OTTMUSP00000048530 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010291 Ion channel regulatory protein, UNC-93
Protein Ontology PR:000017102 protein unc-93 homolog B1
References
(Earliest) J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
(Latest) J:221365 Kanno A, et al., Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases. Nat Commun. 2015;6:6119
All references(71)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory