Unc93b1 MGI Mouse Gene Detail - MGI:1859307 - unc-93 homolog B1, TLR signaling regulator

Symbol

Unc93b1
Name

unc-93 homolog B1, TLR signaling regulator

Feature Type

protein coding gene
IDs

MGI:1859307
NCBI Gene: 54445
Gene Overview

MyGene.info: UNC93B1
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr19:3935186-3949340 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.65 cM
Mapping Data

1 experiment

SNPs within 2kb

70 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859307	protein coding gene	Chr19:3935158-3949340 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024634	protein coding gene	Chr19:744093-759836 (+)
A/J	MGP_AJ_G0024601	protein coding gene	Chr19:711145-725295 (+)
AKR/J	MGP_AKRJ_G0024572	protein coding gene	Chr19:724077-738232 (+)
BALB/cJ	MGP_BALBcJ_G0024599	protein coding gene	Chr19:721406-735673 (+)
C3H/HeJ	MGP_C3HHeJ_G0024368	protein coding gene	Chr19:721702-735896 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025047	protein coding gene	Chr19:749942-764142 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022476	protein coding gene	Chr19:677206-691732 (+)
CAST/EiJ	MGP_CASTEiJ_G0023840	protein coding gene	Chr19:736047-751656 (+)
CBA/J	MGP_CBAJ_G0024338	protein coding gene	Chr19:817900-835053 (+)
DBA/2J	MGP_DBA2J_G0024467	protein coding gene	Chr19:688853-703088 (+)
FVB/NJ	MGP_FVBNJ_G0024434	protein coding gene	Chr19:699138-714230 (+)
LP/J	MGP_LPJ_G0024553	protein coding gene	Chr19:738810-755312 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024464	protein coding gene	Chr19:781463-798884 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025095	protein coding gene	Chr19:728342-742535 (+)
PWK/PhJ	MGP_PWKPhJ_G0023586	protein coding gene	Chr19:719749-735696 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023393	protein coding gene	Chr19:734397-748683 (+)
WSB/EiJ	MGP_WSBEiJ_G0023903	protein coding gene	Chr19:720731-734755 (+)

Human Ortholog

UNC93B1, unc-93 homolog B1, TLR signaling regulator

Vertebrate Orthologs

10

Human Ortholog

UNC93B1, unc-93 homolog B1, TLR signaling regulator
Orthology source: HomoloGene, HGNC
Synonyms

IIAE1, UNC93, UNC93B, Unc-93B1
Links

HGNC:13481

NCBI Gene ID: 81622

neXtProt AC: NX_Q9H1C4

UniProt: Q9H1C4
Chr Location

11q13.2; chr11:67991100-68004125 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41325
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: UNC93B1
Gene Tree

Unc93b1

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Phenotype Summary

54 phenotypes from 3 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
72 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (ENU)

2
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired.

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All GO Annotations

36
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

64

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase unc93b1

ZFIN unc93b1

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Unc93b1 interacts with 103 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

55
RefSeq

6
UniProt

5
CCDS

CCDS29404.2, CCDS50346.1
UniGene

262094

Ensembl

ENSMUSG00000036908 (Evidence)
NCBI Gene

54445

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036908	Ensembl Gene Model \| MGI Sequence Detail	14155	C57BL/6J	± kb
transcript	ENSMUST00000162708	Ensembl \| MGI Sequence Detail	2266	Not Applicable
polypeptide	ENSMUSP00000124272	Ensembl \| MGI Sequence Detail	619	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017102 protein unc-93 homolog B1

(term hierarchy)
InterPro Domains

IPR010291 Ion channel regulatory protein, UNC-93

IPR043268 Protein unc-93 homolog B1

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All nucleic 64

cDNA 64

Microarray probesets 2

Summaries

All 99

Gene Ontology 9

Phenotypes 72
Earliest

J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
Latest

J:287422 Fama A, et al., Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci. mBio. 2020 Mar 24;11(2)

TSS for Unc93b1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154206	Chr19:3935203-3935247 (+)	39 bp
Tssr154207	Chr19:3935252-3935261 (+)	71 bp
Tssr154208	Chr19:3935471-3935483 (+)	291 bp
Tssr154225	Chr19:3941932-3941946 (+)	6,753 bp
Tssr154226	Chr19:3941950-3941971 (+)	6,775 bp
Tssr154227	Chr19:3942368-3942398 (+)	7,197 bp
Tssr154228	Chr19:3943501-3943517 (+)	8,323 bp
Tssr154229	Chr19:3943586-3943610 (+)	8,412 bp
Tssr154230	Chr19:3944146-3944171 (+)	8,973 bp
Tssr154233	Chr19:3948620-3948680 (+)	13,464 bp
Tssr154234	Chr19:3948773-3948785 (+)	13,593 bp
Tssr154235	Chr19:3948859-3948871 (+)	13,679 bp
Tssr154236	Chr19:3949013-3949042 (+)	13,842 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/30/2020 MGI 6.15