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Unc93b1 Gene Detail
Summary
  • Symbol
    Unc93b1
  • Name
    unc-93 homolog B1, TLR signaling regulator
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859307
    NCBI Gene: 54445
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:3985222-3999340 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859307
 protein coding gene Chr19:3985186-3999340 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024634
 protein coding gene Chr19:744093-759836 (+)
A/J MGP_AJ_G0024601
 protein coding gene Chr19:711145-725295 (+)
AKR/J MGP_AKRJ_G0024572
 protein coding gene Chr19:724077-738232 (+)
BALB/cJ MGP_BALBcJ_G0024599
 protein coding gene Chr19:721406-735673 (+)
C3H/HeJ MGP_C3HHeJ_G0024368
 protein coding gene Chr19:721702-735896 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025047
 protein coding gene Chr19:749942-764142 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022476
 protein coding gene Chr19:677206-691732 (+)
CAST/EiJ MGP_CASTEiJ_G0023840
 protein coding gene Chr19:736047-751656 (+)
CBA/J MGP_CBAJ_G0024338
 protein coding gene Chr19:817900-835053 (+)
DBA/2J MGP_DBA2J_G0024467
 protein coding gene Chr19:688853-703088 (+)
FVB/NJ MGP_FVBNJ_G0024434
 protein coding gene Chr19:699138-714230 (+)
LP/J MGP_LPJ_G0024553
 protein coding gene Chr19:738810-755312 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024464
 protein coding gene Chr19:781463-798884 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025095
 protein coding gene Chr19:728342-742535 (+)
PWK/PhJ MGP_PWKPhJ_G0023586
 protein coding gene Chr19:719749-735696 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023393
 protein coding gene Chr19:734397-748683 (+)
WSB/EiJ MGP_WSBEiJ_G0023903
 protein coding gene Chr19:720731-734755 (+)



Homology
more
  • Human Ortholog
    UNC93B1, unc-93 homolog B1, TLR signaling regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UNC93B1, unc-93 homolog B1, TLR signaling regulator
  • Synonyms
    IIAE1, UNC93, UNC93B, Unc-93B1
  • Links
    NCBI Gene ID: 81622
    UniProt: Q9H1C4

  • Chr Location
    11q13.2; chr11:67991100-68004982 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human UNC93B1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    12
  • cDNA Data
    64
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54445 NCBI Gene Model | MGI Sequence Detail 14119 C57BL/6J ±  kb
    transcript NM_019449 RefSeq | MGI Sequence Detail 2230 C57BL/6  
    polypeptide Q8VCW4 UniProt | EBI | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 64
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 1
      Gene Ontology 15
      Phenotypes 101
    • Earliest
      J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
    • Latest
      J:368743 Sato R, et al., RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells. J Exp Med. 2025 Mar 3;222(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory