About   Help   FAQ
Unc93b1 Gene Detail
Summary
  • Symbol
    Unc93b1
  • Name
    unc-93 homolog B1 (C. elegans)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859307
    NCBI Gene: 54445
  • Gene Overview
    MyGene.info: UNC93B1
Location & Maps
more
  • Sequence Map
    Chr19:3935186-3949340 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14155 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    UNC93B1, unc-93 homolog B1 (C. elegans)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UNC93B1, unc-93 homolog B1 (C. elegans)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IIAE1, UNC93, UNC93B, Unc-93B1
  • Links
    NCBI Gene ID: 81622
    neXtProt AC: NX_Q9H1C4

  • Chr Location
    11q13; chr11:67991100-68004125 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human UNC93B1 associations

Human Disease Mouse Models
       Herpes Simplex Encephalitis, Susceptibility to, 1   OMIM: 610551
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (ENU)
    2
  • Targeted
    3
  • Incidental Mutations
Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034969 VEGA Gene Model | MGI Sequence Detail 14155 C57BL/6J ±  kb
transcript OTTMUST00000088920 VEGA | MGI Sequence Detail 2266 Not Applicable  
polypeptide OTTMUSP00000048530 VEGA | MGI Sequence Detail 619 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    70 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017102 protein unc-93 homolog B1
  • InterPro Domains
    IPR010291 Ion channel regulatory protein, UNC-93
Molecular
Reagents
less
  • All nucleic 62
    cDNA 62

    Microarray probesets 2
References
more
  • Summaries
    All 70
    Gene Ontology 7
    Phenotypes 50
  • Earliest
    J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
  • Latest
    J:224475 Mager LF, et al., IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest. 2015 Jul 1;125(7):2579-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory