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Unc93b1
Gene Detail
Symbol

Name
ID
Unc93b1
unc-93 homolog B1 (C. elegans)
MGI:1859307
Feature Type
protein coding gene
Genetic Map
Chromosome 19
3.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:3935186-3949340 bp, + strand
From VEGA annotation of GRCm38

  14155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41325  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Unc93b1

Human
homologs
Human Homolog UNC93B1, unc-93 homolog B1 (C. elegans)
NCBI Gene ID 81622
neXtProt AC  NX_Q9H1C4
Human Synonyms  IIAE1, UNC93, UNC93B, Unc-93B1
Human Chr (Location)  11q13; chr11:67991104-68004123 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human UNC93B1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Chemically induced (ENU)(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired.
 
Interactions
Unc93b1 interacts with 103 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(62)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(62) cDNA(62)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000034969 (Evidence)
Ensembl Gene ModelENSMUSG00000036908 (Evidence)
Entrez Gene54445 (Evidence)
UniGene262094
DFCITC1573365, TC1591147
DoTSDT.101395006, DT.101395010, DT.101352186, DT.94179588, DT.91334770, DT.521709
NIA Mouse Gene IndexU038763
Consensus CDS ProjectCCDS29404.2, CCDS50346.1
International Mouse Knockout Project StatusUnc93b1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034969 VEGA Gene Model | MGI Sequence Detail 14155 C57BL/6J ±  kb
transcript OTTMUST00000088920 VEGA | MGI Sequence Detail 2266 Not Applicable 
polypeptide OTTMUSP00000048530 VEGA | MGI Sequence Detail 619 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010291 Ion channel regulatory protein, UNC-93
Protein Ontology PR:000017102 protein unc-93 homolog B1
References
(Earliest) J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
(Latest) J:211634 Baccala R, et al., Type I interferon is a therapeutic target for virus-induced lethal vascular damage. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8925-30
All references(70)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory