Unc93b1 Gene Detail

Summary

• Symbol
  Unc93b1
• Name
  unc-93 homolog B1 (C. elegans)

• Feature Type
  protein coding gene
• IDs
  MGI:1859307
  NCBI Gene: 54445
• Gene Overview
  MyGene.info: UNC93B1

Location & Maps

• Sequence Map
  Chr19:3935186-3949340 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    14155 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 19, 3.65 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  UNC93B1, unc-93 homolog B1 (C. elegans)

• Vertebrate Orthologs
  10

• Human Ortholog
  UNC93B1, unc-93 homolog B1 (C. elegans)
  Orthology source: HomoloGene, HGNC
• Synonyms
  IIAE1, UNC93, UNC93B, Unc-93B1
• Links
  HGNC:13481

  NCBI Gene ID: 81622

  neXtProt AC: NX_Q9H1C4

  
  
• Chr Location
  11q13; chr11:67991100-68004125 (-)  GRCh38.p2

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• HomoloGene
  Vertebrate Homology Class 41325
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: UNC93B1
• Gene Tree
  Unc93b1
  

Human Diseases

• Diseases
  1 with human UNC93B1 associations

				Human Disease	Mouse Models
				Herpes Simplex Encephalitis, Susceptibility to, 1   OMIM: 610551

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  54 phenotypes from 3 alleles in 4 genetic backgrounds
  4 phenotypes from multigenic genotypes
  50 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (ENU)
  2
• Targeted
  3
• Incidental Mutations
  Mutagenetix , APF , CvDC

Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  28
• GO References
  6

• External Resources
  FuncBase

Expression

• cDNA Data
  62

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  Xenbase unc93b1
  ZFIN unc93b1

Interactions

• Unc93b1 interacts with 103 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

Sequences &
Gene Models

• All Sequences
  35
• RefSeq
  6
• UniProt
  3
• CCDS
  CCDS29404.2, CCDS50346.1
• UniGene
  262094

• VEGA
  OTTMUSG00000034969 (Evidence)
• Ensembl
  ENSMUSG00000036908 (Evidence)
• NCBI Gene
  54445

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000034969	VEGA Gene Model | MGI Sequence Detail	14155	C57BL/6J
transcript	OTTMUST00000088920	VEGA | MGI Sequence Detail	2266	Not Applicable
polypeptide	OTTMUSP00000048530	VEGA | MGI Sequence Detail	619	Not Applicable

Polymorphisms

• SNPs within 2kb
  70 from dbSNP Build 142

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000017102 protein unc-93 homolog B1
• InterPro Domains
  IPR010291 Ion channel regulatory protein, UNC-93

Molecular
Reagents

• All nucleic 62

  cDNA 62

  
  

  Microarray probesets 2

References

• Summaries
  All 70

  Gene Ontology 6

  Phenotypes 50
• Earliest
  J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
• Latest
  J:224475 Mager LF, et al., IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest. 2015 Jul 1;125(7):2579-91