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Unc93b1 Gene Detail
Summary
  • Symbol
    Unc93b1
  • Name
    unc-93 homolog B1 (C. elegans)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859307
    NCBI Gene: 54445
  • Gene Overview
    MyGene.info: UNC93B1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:3935186-3949340 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      14155 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.65 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    UNC93B1, unc-93 homolog B1, TLR signaling regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UNC93B1, unc-93 homolog B1, TLR signaling regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IIAE1, UNC93, UNC93B, Unc-93B1
  • Links
    NCBI Gene ID: 81622
    neXtProt AC: NX_Q9H1C4
    UniProt: Q9H1C4

  • Chr Location
    11q13.2; chr11:67991100-68004125 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    62
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034969 VEGA Gene Model | MGI Sequence Detail 14155 C57BL/6J ±  kb
transcript OTTMUST00000088920 VEGA | MGI Sequence Detail 2266 Not Applicable  
polypeptide OTTMUSP00000048530 VEGA | MGI Sequence Detail 619 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    70 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR010291 Ion channel regulatory protein, UNC-93
Molecular
Reagents
less
  • All nucleic 62
    cDNA 62

    Microarray probesets 2
References
more
  • Summaries
    All 81
    Gene Ontology 8
    Phenotypes 57
  • Earliest
    J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
  • Latest
    J:258639 Roberts AW, et al., Tissue-Resident Macrophages Are Locally Programmed for Silent Clearance of Apoptotic Cells. Immunity. 2017 Nov 21;47(5):913-927.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/15/2018
MGI 6.12 		The Jackson Laboratory