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Unc93b1 Gene Detail
Summary
  • Symbol
    Unc93b1
  • Name
    unc-93 homolog B1, TLR signaling regulator
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859307
    NCBI Gene: 54445
  • Gene Overview
    MyGene.info: UNC93B1
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:3935186-3949340 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.65 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859307
 protein coding gene Chr19:3935186-3949340 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024634
 protein coding gene Chr19:744093-759836 (+)
A/J MGP_AJ_G0024601
 protein coding gene Chr19:711145-725295 (+)
AKR/J MGP_AKRJ_G0024572
 protein coding gene Chr19:724077-738232 (+)
BALB/cJ MGP_BALBcJ_G0024599
 protein coding gene Chr19:721406-735673 (+)
C3H/HeJ MGP_C3HHeJ_G0024368
 protein coding gene Chr19:721702-735896 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025047
 protein coding gene Chr19:749942-764142 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022476
 protein coding gene Chr19:677206-691732 (+)
CAST/EiJ MGP_CASTEiJ_G0023840
 protein coding gene Chr19:736047-751656 (+)
CBA/J MGP_CBAJ_G0024338
 protein coding gene Chr19:817900-835053 (+)
DBA/2J MGP_DBA2J_G0024467
 protein coding gene Chr19:688853-703088 (+)
FVB/NJ MGP_FVBNJ_G0024434
 protein coding gene Chr19:699138-714230 (+)
LP/J MGP_LPJ_G0024553
 protein coding gene Chr19:738810-755312 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024464
 protein coding gene Chr19:781463-798884 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025095
 protein coding gene Chr19:728342-742535 (+)
PWK/PhJ MGP_PWKPhJ_G0023586
 protein coding gene Chr19:719749-735696 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023393
 protein coding gene Chr19:734397-748683 (+)
WSB/EiJ MGP_WSBEiJ_G0023903
 protein coding gene Chr19:720731-734755 (+)



Homology
more
  • Human Ortholog
    UNC93B1, unc-93 homolog B1, TLR signaling regulator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UNC93B1, unc-93 homolog B1, TLR signaling regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IIAE1, UNC93, UNC93B, Unc-93B1
  • Links
    NCBI Gene ID: 81622
    neXtProt AC: NX_Q9H1C4
    UniProt: Q9H1C4

  • Chr Location
    11q13.2; chr11:67991100-68004125 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 3 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with a transmembrane domain point mutation have no overt phenotype but fail to mount a normal cytokine response and exhibit increased susceptibility to mouse cytomegalovirus, Lysteria monocytogenes and Staphlococcus aureus. Antigen presentation by MHC class I and II is impaired.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    50
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    64
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 54445 NCBI Gene Model | MGI Sequence Detail 14155 C57BL/6J ±  kb
transcript NM_019449 RefSeq | MGI Sequence Detail 2277 C57BL/6  
polypeptide Q8VCW4 UniProt | EBI | MGI Sequence Detail 598 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR010291 Ion channel regulatory protein, UNC-93
Molecular
Reagents
less
  • All nucleic 64
    cDNA 64

    Microarray probesets 2
References
more
  • Summaries
    All 86
    Gene Ontology 10
    Phenotypes 61
  • Earliest
    J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
  • Latest
    J:265496 Gonzalez-Quintial R, et al., Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition. PLoS One. 2018;13(9):e0203118
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
01/15/2019
MGI 6.13 		The Jackson Laboratory