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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Unc93b1
unc-93 homolog B1, TLR signaling regulator
MGI:1859307
54 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Unc93b13d/Unc93b13d
C57BL/6-Unc93b13d
abnormal dendritic cell antigen presentation J:159599
abnormal dendritic cell morphology J:159599
decreased interleukin-6 secretion J:159599
decreased interleukin-12b secretion J:159599
Unc93b13d/Unc93b13d
C57BL/6J-Unc93b13d
abnormal antigen presentation via MHC class I J:105484
abnormal antigen presentation via MHC class II J:105484
abnormal circulating interferon level J:105484
abnormal dendritic cell antigen presentation J:105484
abnormal macrophage physiology J:105484
abnormal tumor necrosis factor secretion J:105484
decreased interleukin-12b secretion J:105484
increased circulating tumor necrosis factor level J:105484
increased susceptibility to bacterial infection J:105484
increased susceptibility to Herpesvirales infection J:105484
Unc93b1tm1(KOMP)Vlcg/Unc93b1tm1(KOMP)Vlcg
involves: C57BL/6NTac
abnormal dendritic cell antigen presentation J:211069
abnormal dendritic cell morphology J:211069
abnormal dendritic cell physiology J:211069
abnormal tumor necrosis factor level J:211069
decreased circulating interleukin-6 level J:211069
decreased circulating interleukin-12b level J:211069
Unc93b1tm1.1Kmiy/Unc93b1tm1.1Kmiy
involves: 129P2/OlaHsd * C57BL/6
abnormal bone marrow morphology J:174308
abnormal cytokine secretion J:174308
abnormal erythrocyte physiology J:174308
abnormal liver morphology J:174308
abnormal T-helper 1 cell differentiation J:174308
abnormal T-helper 17 cell differentiation J:174308
anemia J:174308
decreased B cell proliferation J:174308
decreased interferon-alpha secretion J:174308
decreased interleukin-12b secretion J:174308
decreased marginal zone B cell number J:174308
decreased tumor necrosis factor secretion J:174308
enlarged spleen J:174308
glomerulonephritis J:174308
increased anti-nuclear antigen antibody level J:174308
increased autoantibody level J:174308
increased B cell number J:174308
increased B cell proliferation J:174308
increased CD4-positive, alpha-beta memory T cell number J:174308
increased circulating alanine transaminase level J:174308
increased circulating aspartate transaminase level J:174308
increased circulating bilirubin level J:174308
increased circulating creatinine level J:174308
increased circulating lactate dehydrogenase level J:174308
increased erythroblast number J:174308
increased IgG2a level J:174308
increased IgG2b level J:174308
increased interferon-alpha secretion J:174308
increased interleukin-12b secretion J:174308
increased memory T cell number J:174308
increased spleen weight J:174308
increased T-helper 1 cell number J:174308
increased T-helper 17 cell number J:174308
increased tumor necrosis factor secretion J:174308
liver failure J:174308
liver inflammation J:174308
multifocal hepatic necrosis J:174308
premature death J:174308
thrombocytopenia J:174308

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory