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Azin1 Gene Detail
Summary
  • Symbol
    Azin1
  • Name
    antizyme inhibitor 1
  • Synonyms
    1700085L02Rik, Oazi, Oazin, ODC antizyme inhibitor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859169
    NCBI Gene: 54375
  • Gene Overview
    MyGene.info: AZIN1
Location & Maps
more
  • Sequence Map
    Chr15:38487430-38519266 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31837 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.17 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AZIN1, antizyme inhibitor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AZIN1, antizyme inhibitor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AZI, AZIA1, OAZI, OAZIN, ODC1L
  • Links
    NCBI Gene ID: 51582
    neXtProt AC: NX_O14977

  • Chr Location
    8q22.3; chr8:102826302-102864200 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    2
  • Gene trapped
    23
  • Targeted
    2
  • Genomic Mutations
    2 involving Azin1
  • Incidental Mutations
Homozygous disruption of this gene results in neonatal lethality, a slight reduction in birth weight, and abnormal liver morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024581 VEGA Gene Model | MGI Sequence Detail 31837 C57BL/6J ±  kb
transcript OTTMUST00000060391 VEGA | MGI Sequence Detail 4868 Not Applicable  
polypeptide OTTMUSP00000029456 VEGA | MGI Sequence Detail 448 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    118 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 23
    cDNA 22
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1920775, MGI:2145992
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:61073 Nilsson J, et al., Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression. Biochem J. 2000 Mar 15;346 Pt 3:699-704
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory