Azin1 MGI Mouse Gene Detail - MGI:1859169

Symbol

Azin1
Name

antizyme inhibitor 1
Synonyms

1700085L02Rik, Oazi, Oazin, ODC antizyme inhibitor

Feature Type

protein coding gene
IDs

MGI:1859169
NCBI Gene: 54375
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:38487674-38523506 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 15.17 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

821 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1859169	protein coding gene	Chr15:38487671-38523506 (-)
129S1/SvImJ	ENSMUSG00200026491	protein coding gene	Chr15:35486946-35501075 (-)
A/J	ENSMUSG00195034890	protein coding gene	Chr15:35414274-35428454 (-)
AKR/J	ENSMUSG00220026313	protein coding gene	Chr15:35328130-35342312 (-)
BALB/cJ	ENSMUSG00180029467	protein coding gene	Chr15:35394853-35409026 (-)
C3H/HeJ	ENSMUSG00175026914	protein coding gene	Chr15:35590116-35604244 (-)
C57BL/6NJ	ENSMUSG00215014950	protein coding gene	Chr15:35401323-35415497 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019751	protein coding gene	Chr15:33347645-33379112 (-)
CAST/EiJ	ENSTCUG00005010309	protein coding gene	Chr15:35411851-35426207 (-)
CBA/J	ENSMUSG00210017652	protein coding gene	Chr15:35507873-35522049 (-)
DBA/2J	ENSMUSG00185032964	protein coding gene	Chr15:35488740-35502920 (-)
FVB/NJ	ENSMUSG00205026356	protein coding gene	Chr15:35380668-35394844 (-)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230010415	protein coding gene	Chr15:38868027-38882144 (-)
NOD/ShiLtJ	ENSMUSG00190023712	protein coding gene	Chr15:35454992-35469116 (-)
NZO/HlLtJ	ENSMUSG00225030834	protein coding gene	Chr15:39176207-39190336 (-)
PWK/PhJ	ENSLUMG00010028691	protein coding gene	Chr15:35534302-35548439 (-)
SPRET/EiJ	ENSMSPG00010012061	protein coding gene	Chr15:36193835-36208218 (-)
WSB/EiJ	ENSIUOG00005030665	protein coding gene	Chr15:35503950-35518069 (-)

Human Ortholog

AZIN1, antizyme inhibitor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AZIN1, antizyme inhibitor 1
Synonyms

AZI, AZI1, AZIA1, OAZI, OAZIN, ODC1L
Links

HGNC:16432

NCBI Gene ID: 51582

UniProt: O14977
Chr Location

8q22.3; chr8:102826111-102893864 (-) GRCh38

MGI Vertebrate Homology

Azin1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: AZIN1

Diseases

3 with human AZIN1 associations

				Human Disease	Mouse Models
				esophagus squamous cell carcinoma IDs esophagus squamous cell carcinoma DOID:3748 MESH:D000077277 NCI:C4024 UMLS_CUI:C0279626
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

19
Targeted

2
Genomic Mutations

2 involving Azin1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous disruption of this gene results in neonatal lethality, a slight reduction in birth weight, and abnormal liver morphology.

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All GO Annotations

29
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

11
Tissues

9
cDNA Data

22
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase azin1

ZFIN azin1a, azin1b

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All Sequences

84
RefSeq

15
UniProt

6
CCDS

CCDS37065.1

Ensembl

ENSMUSG00000037458 (Evidence), ENSMUSG00000144219 (Evidence)
NCBI Gene

54375

			Length	Strain/Species	Flank
genomic	54375	NCBI Gene Model \| MGI Sequence Detail	35833	C57BL/6J	± kb
transcript	NM_001102458	RefSeq \| MGI Sequence Detail	5028	ZRU/MplStud
polypeptide	O35484	UniProt \| EBI \| MGI Sequence Detail	448	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004533 antizyme inhibitor 1

(term hierarchy)
PDB

3BTN
InterPro Domains

IPR009006 Alanine racemase/group IV decarboxylase, C-terminal

IPR031178 Antizyme inhibitor 1

IPR022657 Orn/DAP/Arg decarboxylase 2, conserved site

IPR022644 Orn/DAP/Arg decarboxylase 2, N-terminal

IPR000183 Ornithine/DAP/Arg decarboxylase

IPR002433 Ornithine decarboxylase

IPR029066 PLP-binding barrel

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All nucleic 24

cDNA 23

Primer pair 1

Microarray probesets 5

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MGI:1920775, MGI:2145992

Summaries

All 52

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:361327 Heruye SH, et al., Inflammation primes the murine kidney for recovery by activating AZIN1 adenosine-to-inosine editing. J Clin Invest. 2024 Sep 3;134(17)

TSS for Azin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134133	Chr15:38519499-38519515 (-)	3,999 bp
Tssr134132	Chr15:38518457-38518474 (-)	5,040 bp
Tssr134131	Chr15:38518435-38518456 (-)	5,060 bp
Tssr4581	Chr15:38515069-38515074 (-)	8,434 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24