About   Help   FAQ
Nell2 Gene Detail
Summary
  • Symbol
    Nell2
  • Name
    NEL-like 2
  • Synonyms
    A330108N19Rik, mel91
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858510
    NCBI Gene: 54003
  • Gene Overview
    MyGene.info: NELL2
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:95219440-95528796 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 49.39 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2218 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858510
 protein coding gene Chr15:95075230-95528796 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022263
 protein coding gene Chr15:96723513-97046042 (-)
A/J MGP_AJ_G0022222
 protein coding gene Chr15:92959016-93267051 (-)
AKR/J MGP_AKRJ_G0022197
 protein coding gene Chr15:95755969-96067628 (-)
BALB/cJ MGP_BALBcJ_G0022228
 protein coding gene Chr15:93129385-93440675 (-)
C3H/HeJ MGP_C3HHeJ_G0021998
 protein coding gene Chr15:95785216-96109371 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022673
 protein coding gene Chr15:100292763-100636229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020199
 protein coding gene Chr15:88975183-89272801 (-)
CAST/EiJ MGP_CASTEiJ_G0021520
 protein coding gene Chr15:96630513-96952637 (-)
CBA/J MGP_CBAJ_G0021965
 protein coding gene Chr15:103658327-103996932 (-)
DBA/2J MGP_DBA2J_G0022092
 protein coding gene Chr15:92402583-92712444 (-)
FVB/NJ MGP_FVBNJ_G0022071
 protein coding gene Chr15:91405618-91701954 (-)
LP/J MGP_LPJ_G0022163
 protein coding gene Chr15:96849928-97176704 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022091
 protein coding gene Chr15:107927001-108265573 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022688
 protein coding gene Chr15:95846639-96166468 (-)
PWK/PhJ MGP_PWKPhJ_G0021261
 protein coding gene Chr15:92465039-92773393 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021095
 protein coding gene Chr15:95615622-95938625 (-)
WSB/EiJ MGP_WSBEiJ_G0021569
 protein coding gene Chr15:96353432-96682413 (-)



Homology
more
  • Human Ortholog
    NELL2, neural EGFL like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NELL2, neural EGFL like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NRP2
  • Links
    NCBI Gene ID: 4753
    neXtProt AC: NX_Q99435
    UniProt: Q99435

  • Chr Location
    12q12; chr12:44508275-44921848 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 4488
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NELL2
  • Gene Tree
    Nell2
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 2 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display enhanced long term potentiation in the dentate gyrus of the hippocampus. Male mice homozygous for a null allele exhibit infertility, impaired binding of sperm to zona pellucida, and impaired sperm migration in female genital tract.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    981
  • Tissues
    65
  • cDNA Data
    61
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54003 NCBI Gene Model | MGI Sequence Detail 309357 C57BL/6J ±  kb
    transcript NM_001356950 RefSeq | MGI Sequence Detail 3429 C57BL/6  
    polypeptide Q61220 UniProt | EBI | MGI Sequence Detail 819 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 61
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2146325, MGI:2444983
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 4
      Phenotypes 25
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:290452 Kiyozumi D, et al., NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science. 2020 Jun 5;368(6495):1132-1135
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    02/23/2021
    MGI 6.16     		The Jackson Laboratory