Nell2 MGI Mouse Gene Detail - MGI:1858510

Symbol

Nell2
Name

NEL-like 2
Synonyms

A330108N19Rik, mel91

Feature Type

protein coding gene
IDs

MGI:1858510
NCBI Gene: 54003
Gene Overview

MyGene.info: NELL2
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr15:95219440-95528759 bp, - strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 49.39 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

2218 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858510	protein coding gene	Chr15:95075230-95528759 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022263	protein coding gene	Chr15:96723513-97046042 (-)
A/J	MGP_AJ_G0022222	protein coding gene	Chr15:92959016-93267051 (-)
AKR/J	MGP_AKRJ_G0022197	protein coding gene	Chr15:95755969-96067628 (-)
BALB/cJ	MGP_BALBcJ_G0022228	protein coding gene	Chr15:93129385-93440675 (-)
C3H/HeJ	MGP_C3HHeJ_G0021998	protein coding gene	Chr15:95785216-96109371 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022673	protein coding gene	Chr15:100292763-100636229 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020199	protein coding gene	Chr15:88975183-89272801 (-)
CAST/EiJ	MGP_CASTEiJ_G0021520	protein coding gene	Chr15:96630513-96952637 (-)
CBA/J	MGP_CBAJ_G0021965	protein coding gene	Chr15:103658327-103996932 (-)
DBA/2J	MGP_DBA2J_G0022092	protein coding gene	Chr15:92402583-92712444 (-)
FVB/NJ	MGP_FVBNJ_G0022071	protein coding gene	Chr15:91405618-91701954 (-)
LP/J	MGP_LPJ_G0022163	protein coding gene	Chr15:96849928-97176704 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022091	protein coding gene	Chr15:107927001-108265573 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022688	protein coding gene	Chr15:95846639-96166468 (-)
PWK/PhJ	MGP_PWKPhJ_G0021261	protein coding gene	Chr15:92465039-92773393 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021095	protein coding gene	Chr15:95615622-95938625 (-)
WSB/EiJ	MGP_WSBEiJ_G0021569	protein coding gene	Chr15:96353432-96682413 (-)

Human Ortholog

NELL2, neural EGFL like 2

Vertebrate Orthologs

10

Human Ortholog

NELL2, neural EGFL like 2
Orthology source: HomoloGene, HGNC
Synonyms

NRP2
Links

HGNC:7751

NCBI Gene ID: 4753

neXtProt AC: NX_Q99435

UniProt: Q99435
Chr Location

12q12; chr12:44508275-44921848 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4488
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NELL2
Gene Tree

Nell2

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Nell2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

1 strains or lines available

Homozygous null mice display enhanced long term potentiation in the dentate gyrus of the hippocampus.

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All GO Annotations

18
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

325
Tissues

50
cDNA Data

60
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NELL2

Xenbase nell2

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Nell2 interacts with 124 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

49
RefSeq

10
UniProt

4
CCDS

CCDS27775.1
UniGene

3959

Ensembl

ENSMUSG00000022454 (Evidence)
NCBI Gene

54003

			Length	Strain/Species	Flank
genomic	54003	NCBI Gene Model \| MGI Sequence Detail	309320	C57BL/6J	± kb
transcript	NM_001356950	RefSeq \| MGI Sequence Detail	3429	C57BL/6
polypeptide	Q61220	UniProt \| EBI \| MGI Sequence Detail	819	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000011138 protein kinase C-binding protein NELL2

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR024731 EGF domain

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR013032 EGF-like, conserved site

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR001791 Laminin G domain

IPR001007 VWFC domain

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All nucleic 61

cDNA 60

Primer pair 1

Microarray probesets 2

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MGI:2146325, MGI:2444983

Summaries

All 55

Developmental Gene Expression 10

Diseases 1

Gene Ontology 4

Phenotypes 22
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:276901 Taroc EZM, et al., GnRH-1 Neural Migration From the Nose to the Brain Is Independent From Slit2, Robo3 and NELL2 Signaling. Front Cell Neurosci. 2019;13:70

TSS for Nell2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136004	Chr15:95528702-95528777 (-)	19 bp
Tssr136003	Chr15:95528577-95528640 (-)	150 bp
Tssr136002	Chr15:95528542-95528565 (-)	205 bp
Tssr136001	Chr15:95528429-95528445 (-)	322 bp
Tssr136000	Chr15:95528228-95528266 (-)	512 bp
Tssr135999	Chr15:95528124-95528192 (-)	601 bp
Tssr135998	Chr15:95528078-95528123 (-)	658 bp
Tssr135997	Chr15:95527978-95528014 (-)	763 bp
Tssr135996	Chr15:95527959-95527973 (-)	793 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/13/2019 MGI 6.14