Ppm1d
Gene Detail

Symbol Name ID

Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform MGI:1858214

Synonyms

Wip1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

51.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:85311244-85347066 bp, + strand From VEGA annotation of GRCm38   35823 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31185  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Ppm1d

Human homologs

Human Homolog		PPM1D, protein phosphatase, Mg2+/Mn2+ dependent, 1D
NCBI Gene ID		8493
neXtProt AC		NX_O15297
Human Synonyms		PP2C-DELTA, WIP1
Human Chr (Location)		17q23.2; chr17:60600183-60666280 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human PPM1D

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous null male mice show some embryonic lethality. Surviving males have variable abnormalities including runting, reproductive organ atrophy with associated reduced fertility, and reduced life span. Both genders have increased susceptibility to viral infection and reduced lymphocyte function.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell cycle, dephosphorylation, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (26)    Tissues (23)   
Theiler Stages: 13, 15, 17, 20, 26, 28

Assay Type	Results
RNA in situ	1
Northern blot	1
RT-PCR	24

cDNA source data(46)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) cDNA(49) Primer pair(3)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000001033 (Evidence)
Ensembl Gene Model	ENSMUSG00000020525 (Evidence)
Entrez Gene	53892 (Evidence)
UniGene	45609
DFCI	TC1578698, TC1589937
DoTS	DT.489522, DT.94277517, DT.94277518, DT.99867939
NIA Mouse Gene Index	U043207
EC	3.1.3.16
Consensus CDS Project	CCDS25194.1
International Mouse Knockout Project Status	Ppm1d

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001033	VEGA Gene Model | MGI Sequence Detail	35823	C57BL/6J
transcript	OTTMUST00000002063	VEGA | MGI Sequence Detail	2899	Not Applicable
polypeptide	OTTMUSP00000000998	VEGA | MGI Sequence Detail	598	Not Applicable

All sequences(47) RefSeq(2) UniProt(7)

Polymorphisms

SNPs within 2kb(280 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR015655	Protein phosphatase 2C
InterPro	IPR000222	Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro	IPR001932	Protein phosphatase 2C (PP2C)-like
Protein Ontology	PR:000013092	protein phosphatase 1D

References

(Earliest) J:61530 Choi J, et al., The structure and expression of the murine wildtype p53-induced phosphatase 1 (Wip1) gene. Genomics. 2000 Mar 15;64(3):298-306
(Latest) J:206531 Filipponi D, et al., Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation. Cancer Cell. 2013 Oct 14;24(4):528-41
All references(51)

Other accession IDs

MGI:2144473