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Ppm1d Gene Detail
Summary
  • Symbol
    Ppm1d
  • Name
    protein phosphatase 1D magnesium-dependent, delta isoform
  • Synonyms
    Wip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858214
    NCBI Gene: 53892
  • Gene Overview
    MyGene.info: PPM1D
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:85311244-85347066 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35823 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.34 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IDDGIP, PP2C-DELTA, WIP1
  • Links
    NCBI Gene ID: 8493
    neXtProt AC: NX_O15297
    UniProt: O15297

  • Chr Location
    17q23.2; chr17:60600183-60666280 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31185
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PPM1D
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PPM1D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null male mice show some embryonic lethality. Surviving males have variable abnormalities including runting, reproductive organ atrophy with associated reduced fertility, and reduced life span. Both genders have increased susceptibility to viral infection and reduced lymphocyte function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000001033 VEGA Gene Model | MGI Sequence Detail 35823 C57BL/6J ±  kb
    transcript OTTMUST00000002063 VEGA | MGI Sequence Detail 2899 Not Applicable  
    polypeptide OTTMUSP00000000998 VEGA | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      277 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 49
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144473
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 33
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:225921 Yi W, et al., Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner. Blood. 2015 Jul 30;126(5):620-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory