About   Help   FAQ
Ppm1d
Gene Detail
Symbol

Name
ID
Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
MGI:1858214
Synonyms
Wip1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
51.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:85311244-85347066 bp, + strand
From VEGA annotation of GRCm38

  35823 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31185  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Ppm1d

Human
homologs
Human Homolog PPM1D, protein phosphatase, Mg2+/Mn2+ dependent, 1D
NCBI Gene ID 8493
neXtProt AC  NX_O15297
Human Synonyms  PP2C-DELTA, WIP1
Human Chr (Location)  17q23.2; chr17:60600183-60666280 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PPM1D
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null male mice show some embryonic lethality. Surviving males have variable abnormalities including runting, reproductive organ atrophy with associated reduced fertility, and reduced life span. Both genders have increased susceptibility to viral infection and reduced lymphocyte function.
 
Interactions
Ppm1d interacts with 224 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process cell cycle, dephosphorylation, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (26)    Tissues (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
Northern blot 1
RT-PCR 24
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(49) Primer pair(3)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000001033 (Evidence)
Ensembl Gene ModelENSMUSG00000020525 (Evidence)
Entrez Gene53892 (Evidence)
UniGene45609
DFCITC1578698, TC1589937
DoTSDT.94277518, DT.94277517, DT.489522, DT.99867939
NIA Mouse Gene IndexU043207
EC3.1.3.16
Consensus CDS ProjectCCDS25194.1
International Mouse Knockout Project StatusPpm1d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001033 VEGA Gene Model | MGI Sequence Detail 35823 C57BL/6J ±  kb
transcript OTTMUST00000002063 VEGA | MGI Sequence Detail 2899 Not Applicable 
polypeptide OTTMUSP00000000998 VEGA | MGI Sequence Detail 598 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(13)
Polymorphisms
SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015655 Protein phosphatase 2C
InterPro IPR000222 Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like
Protein Ontology PR:000013092 protein phosphatase 1D
References
(Earliest) J:61530 Choi J, et al., The structure and expression of the murine wildtype p53-induced phosphatase 1 (Wip1) gene. Genomics. 2000 Mar 15;64(3):298-306
(Latest) J:213794 Zhu Y, et al., Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest. 2014 Jul 1;124(7):3263-73
All references(53)
Other
accession IDs
MGI:2144473

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory