Ppm1d MGI Mouse Gene Detail - MGI:1858214 - protein phosphatase 1D magnesium-dependent, delta isoform

Symbol

Ppm1d
Name

protein phosphatase 1D magnesium-dependent, delta isoform
Synonyms

Wip1

Feature Type

protein coding gene
IDs

MGI:1858214
NCBI Gene: 53892
Gene Overview

MyGene.info: PPM1D
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr11:85311254-85347071 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.34 cM
Mapping Data

3 experiments

SNPs within 2kb

277 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858214	protein coding gene	Chr11:85311244-85347071 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0018881	protein coding gene	Chr11:86806788-86849405 (+)
A/J	MGP_AJ_G0018848	protein coding gene	Chr11:83475129-83516764 (+)
AKR/J	MGP_AKRJ_G0018818	protein coding gene	Chr11:85973728-86016818 (+)
BALB/cJ	MGP_BALBcJ_G0018821	protein coding gene	Chr11:83865599-83901080 (+)
C3H/HeJ	MGP_C3HHeJ_G0018635	protein coding gene	Chr11:86005496-86045253 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019273	protein coding gene	Chr11:89454864-89491095 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016906	protein coding gene	Chr11:80530721-80564020 (+)
CAST/EiJ	MGP_CASTEiJ_G0018190	protein coding gene	Chr11:86654467-86692676 (+)
CBA/J	MGP_CBAJ_G0018606	protein coding gene	Chr11:93241324-93292110 (+)
DBA/2J	MGP_DBA2J_G0018714	protein coding gene	Chr11:83052761-83089903 (+)
FVB/NJ	MGP_FVBNJ_G0018703	protein coding gene	Chr11:82553606-82590521 (+)
LP/J	MGP_LPJ_G0018784	protein coding gene	Chr11:87320462-87358325 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018730	protein coding gene	Chr11:93373651-93414033 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019313	protein coding gene	Chr11:86225106-86262478 (+)
PWK/PhJ	MGP_PWKPhJ_G0017959	protein coding gene	Chr11:83827568-83865227 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017751	protein coding gene	Chr11:85761832-85811696 (+)
WSB/EiJ	MGP_WSBEiJ_G0018241	protein coding gene	Chr11:86068952-86112631 (+)

Human Ortholog

PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D

Vertebrate Orthologs

11

Human Ortholog

PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D
Orthology source: HomoloGene, HGNC
Synonyms

IDDGIP, PP2C-DELTA, WIP1
Links

HGNC:9277

NCBI Gene ID: 8493

neXtProt AC: NX_O15297

UniProt: O15297
Chr Location

17q23.2; chr17:60600183-60666280 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 31185
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PPM1D
Gene Tree

Ppm1d

Diseases

1 with human PPM1D associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD10CM:C50-C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 1 allele in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

4
Genomic Mutations

2 involving Ppm1d
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null male mice show some embryonic lethality. Surviving males have variable abnormalities including runting, reproductive organ atrophy with associated reduced fertility, and reduced life span. Both genders have increased susceptibility to viral infection and reduced lymphocyte function.

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All GO Annotations

21
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

26
Tissues

23
cDNA Data

47
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppm1d

ZFIN ppm1da, ppm1db

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Ppm1d interacts with 224 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

54
RefSeq

2
UniProt

7
CCDS

CCDS25194.1
UniGene

45609

Ensembl

ENSMUSG00000020525 (Evidence)
NCBI Gene

53892

			Length	Strain/Species	Flank
genomic	53892	NCBI Gene Model \| MGI Sequence Detail	35818	C57BL/6J	± kb
transcript	NM_016910	RefSeq \| MGI Sequence Detail	2911	C57BL/6
polypeptide	Q9QZ67	UniProt \| EBI \| MGI Sequence Detail	598	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013092 protein phosphatase 1D

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR000222 PPM-type phosphatase, divalent cation binding

IPR001932 PPM-type phosphatase domain

IPR036457 PPM-type phosphatase domain superfamily

IPR015655 Protein phosphatase 2C family

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All nucleic 53

cDNA 50

Primer pair 3

Microarray probesets 6

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MGI:2144473

Summaries

All 64

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 33
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:225921 Yi W, et al., Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner. Blood. 2015 Jul 30;126(5):620-8

TSS for Ppm1d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103823	Chr11:85311190-85311210 (+)	-54 bp
Tssr103824	Chr11:85311232-85311286 (+)	5 bp
Tssr103825	Chr11:85311289-85311325 (+)	53 bp
Tssr103826	Chr11:85311346-85311395 (+)	117 bp
Tssr103827	Chr11:85311401-85311412 (+)	153 bp
Tssr103828	Chr11:85312138-85312149 (+)	890 bp
Tssr103829	Chr11:85312172-85312180 (+)	922 bp
Tssr103830	Chr11:85339668-85339677 (+)	28,419 bp
Tssr103831	Chr11:85339699-85339759 (+)	28,475 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 11/06/2018 MGI 6.13