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Ppm1d Gene Detail
Summary
  • Symbol
    Ppm1d
  • Name
    protein phosphatase 1D magnesium-dependent, delta isoform
  • Synonyms
    Wip1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858214
    NCBI Gene: 53892
  • Gene Overview
    MyGene.info: PPM1D
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:85311254-85347071 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858214
protein coding gene Chr11:85311244-85347071 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018881
protein coding gene Chr11:86806788-86849405 (+)
A/J MGP_AJ_G0018848
protein coding gene Chr11:83475129-83516764 (+)
AKR/J MGP_AKRJ_G0018818
protein coding gene Chr11:85973728-86016818 (+)
BALB/cJ MGP_BALBcJ_G0018821
protein coding gene Chr11:83865599-83901080 (+)
C3H/HeJ MGP_C3HHeJ_G0018635
protein coding gene Chr11:86005496-86045253 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019273
protein coding gene Chr11:89454864-89491095 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016906
protein coding gene Chr11:80530721-80564020 (+)
CAST/EiJ MGP_CASTEiJ_G0018190
protein coding gene Chr11:86654467-86692676 (+)
CBA/J MGP_CBAJ_G0018606
protein coding gene Chr11:93241324-93292110 (+)
DBA/2J MGP_DBA2J_G0018714
protein coding gene Chr11:83052761-83089903 (+)
FVB/NJ MGP_FVBNJ_G0018703
protein coding gene Chr11:82553606-82590521 (+)
LP/J MGP_LPJ_G0018784
protein coding gene Chr11:87320462-87358325 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018730
protein coding gene Chr11:93373651-93414033 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019313
protein coding gene Chr11:86225106-86262478 (+)
PWK/PhJ MGP_PWKPhJ_G0017959
protein coding gene Chr11:83827568-83865227 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017751
protein coding gene Chr11:85761832-85811696 (+)
WSB/EiJ MGP_WSBEiJ_G0018241
protein coding gene Chr11:86068952-86112631 (+)



Homology
more
  • Human Ortholog
    PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IDDGIP, PP2C-DELTA, WIP1
  • Links
    NCBI Gene ID: 8493
    neXtProt AC: NX_O15297
    UniProt: O15297

  • Chr Location
    17q23.2; chr17:60600183-60666280 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31185
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PPM1D
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human PPM1D associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null male mice show some embryonic lethality. Surviving males have variable abnormalities including runting, reproductive organ atrophy with associated reduced fertility, and reduced life span. Both genders have increased susceptibility to viral infection and reduced lymphocyte function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 53892 NCBI Gene Model | MGI Sequence Detail 35818 C57BL/6J ±  kb
    transcript NM_016910 RefSeq | MGI Sequence Detail 2911 C57BL/6  
    polypeptide Q9QZ67 UniProt | EBI | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 50
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144473
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 33
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:225921 Yi W, et al., Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner. Blood. 2015 Jul 30;126(5):620-8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory