Ppm1d
Gene Detail

Symbol

Name
ID

Ppm1d
protein phosphatase 1D magnesium-dependent, delta isoform
MGI:1858214

Synonyms

Wip1

Feature Type

protein coding gene

Genetic Map

Chromosome 11
51.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:85311244-85347066 bp, + strand From VEGA annotation of GRCm38   35823 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:31185  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Ppm1d

Human
homologs

Human Homolog		PPM1D, protein phosphatase, Mg2+/Mn2+ dependent, 1D
NCBI Gene ID		8493
neXtProt AC		NX_O15297
Human Synonyms		PP2C-DELTA, WIP1
Human Chr (Location)		17q23.2; chr17:60600183-60666280 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human PPM1D

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Ppm1d (1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null male mice show some embryonic lethality. Surviving males have variable abnormalities including runting, reproductive organ atrophy with associated reduced fertility, and reduced life span. Both genders have increased susceptibility to viral infection and reduced lymphocyte function.

 

Interactions

Ppm1d interacts with 224 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (13 annotations)

Process	cell cycle, dephosphorylation, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)

Data Summary: Results (26)    Tissues (23)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	1
Northern blot	1
RT-PCR	24

cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(52) cDNA(49) Primer pair(3)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000001033 (Evidence)
Ensembl Gene Model	ENSMUSG00000020525 (Evidence)
Entrez Gene	53892 (Evidence)
UniGene	45609
DFCI	TC1578698, TC1589937
DoTS	DT.94277517, DT.489522, DT.94277518, DT.99867939
NIA Mouse Gene Index	U043207
EC	3.1.3.16
Consensus CDS Project	CCDS25194.1
International Mouse Knockout Project Status	Ppm1d

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001033	VEGA Gene Model | MGI Sequence Detail	35823	C57BL/6J
transcript	OTTMUST00000002063	VEGA | MGI Sequence Detail	2899	Not Applicable
polypeptide	OTTMUSP00000000998	VEGA | MGI Sequence Detail	598	Not Applicable

All sequences(53) RefSeq(2) UniProt(13)

Polymorphisms

SNPs within 2kb(280 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR015655	Protein phosphatase 2C
InterPro	IPR000222	Protein phosphatase 2C, manganese/magnesium aspartate binding site
InterPro	IPR001932	Protein phosphatase 2C (PP2C)-like
Protein Ontology	PR:000013092	protein phosphatase 1D

References

(Earliest) J:61530 Choi J, et al., The structure and expression of the murine wildtype p53-induced phosphatase 1 (Wip1) gene. Genomics. 2000 Mar 15;64(3):298-306
(Latest) J:213794 Zhu Y, et al., Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging. J Clin Invest. 2014 Jul 1;124(7):3263-73
All references(53)

Other
accession IDs

MGI:2144473