Ppm1d MGI Mouse Gene Detail - MGI:1858214 - protein phosphatase 1D magnesium-dependent, delta isoform

Ppm1d Gene Detail

Symbol

Ppm1d
Name

protein phosphatase 1D magnesium-dependent, delta isoform
Synonyms

Wip1

Feature Type

protein coding gene
IDs

MGI:1858214
NCBI Gene: 53892
Gene Overview

MyGene.info: PPM1D

Sequence Map

Chr11:85311244-85347066 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

35823 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 51.34 cM
Mapping Data

3 experiments

Human Ortholog

PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D

Vertebrate Orthologs

11

Human Ortholog

PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D
Orthology source: HomoloGene, HGNC
Synonyms

IDDGIP, PP2C-DELTA, WIP1
Links

HGNC:9277

NCBI Gene ID: 8493

neXtProt AC: NX_O15297

UniProt: O15297
Chr Location

17q23.2; chr17:60600183-60666280 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 31185
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PPM1D
Gene Tree

Ppm1d

Diseases

1 with human PPM1D associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD10CM:C50-C50 ICD9CM:174.8 MESH:D001943 NCI:C2910 NCI:C9335 OMIM:114480 OMIM:600048 OMIM:605365 UMLS_CUI:C0006142 UMLS_CUI:C0153555 UMLS_CUI:C1458155

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 1 allele in 2 genetic backgrounds
4 phenotypes from multigenic genotypes
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

4
Genomic Mutations

2 involving Ppm1d
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available

Homozygous null male mice show some embryonic lethality. Surviving males have variable abnormalities including runting, reproductive organ atrophy with associated reduced fertility, and reduced life span. Both genders have increased susceptibility to viral infection and reduced lymphocyte function.

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All GO Annotations

14
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

26
Tissues

23
cDNA Data

46
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN ppm1da, ppm1db

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Ppm1d interacts with 224 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

41
RefSeq

2
UniProt

7
CCDS

CCDS25194.1
UniGene

45609

			Length	Strain/Species	Flank
genomic	OTTMUSG00000001033	VEGA Gene Model \| MGI Sequence Detail	35823	C57BL/6J	± kb
transcript	OTTMUST00000002063	VEGA \| MGI Sequence Detail	2899	Not Applicable
polypeptide	OTTMUSP00000000998	VEGA \| MGI Sequence Detail	598	Not Applicable

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SNPs within 2kb

277 from dbSNP Build 142

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UniProt

7 Sequences
Protein Ontology

PR:000013092 protein phosphatase 1D

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR000222 PPM-type phosphatase, divalent cation binding

IPR001932 PPM-type phosphatase domain

IPR015655 Protein phosphatase 2C family

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All nucleic 52

cDNA 49

Primer pair 3

Microarray probesets 6

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MGI:2144473

Summaries

All 62

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 32
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:225921 Yi W, et al., Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner. Blood. 2015 Jul 30;126(5):620-8

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/08/2017 MGI 6.10